Ternary-code DNA methylation dynamics: A new era for scalable mapping [0.03%]
三进制DNA甲基化动态学：可扩展图谱的新纪元
Yubin Zhou,Yun Huang
Yubin Zhou
The preview discusses the scalable platform for methylation-based trait mapping published in Cell Genomics by Goldberg et al.1 This work represents not only a methodological advance but also marks a conceptual shift toward scalable and high...
Genetic history and adaptation of Eurasian wild boars inform livestock breeding [0.03%]
欧亚野猪的遗传史和适应性研究为家猪育种提供信息
Ji Yang,Wen-Tian Wei,Meng-Hua Li
Ji Yang
Historical expansions of wild boars (Sus scrofa) across Eurasia have shaped phenotypic variation, genetic diversity, and local adaptation of their populations. The study by Wang et al.1 investigates the demographic history and genetic adapt...
Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8 [0.03%]
人类B细胞限制性受体P2RY8错义突变的多效性表型研究
Taylor N LaFlam,Christian B Billesbølle,Tuan Dinh et al.
Taylor N LaFlam et al.
Missense variants can have pleiotropic effects on protein function, and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G protein-coupled receptor that promotes germinal center B ...
Detection of heterogeneous resistance mechanisms to tyrosine kinase inhibitors from cell-free DNA [0.03%]
从细胞游离DNA检测酪氨酸激酶抑制剂的异质性耐药机制
Heather A Parsons,Conor Messer,Katheryn Santos et al.
Heather A Parsons et al.
Though there has been substantial progress in the development of anti-human epidermal growth factor receptor 2 (HER2) therapies to treat HER2-positive metastatic breast cancer (MBC) within the past two decades, most patients still experienc...
Sebastian Palacios,Simone Bruno,Ron Weiss et al.
Sebastian Palacios et al.
Cells store information by means of chromatin modifications that persist through cell divisions and can hold gene expression silenced over generations. However, how these modifications may maintain other gene expression states has remained ...
A peptide display system identifies a potent mutant β-melanocyte-stimulating hormone agonist of melanocortin-4 receptor [0.03%]
一种肽展示系统鉴定出的一种有效的黑色素皮质激素受体4激动剂变异体
Ann Lin,Kaitlyn Spees,Raeline Valbuena et al.
Ann Lin et al.
Non-olfactory G-protein-coupled receptors (GPCRs) regulate vital physiological functions and are targets for ∼34% of US Food and Drug Administration (FDA)-approved drugs. While small-molecule-activated GPCRs are well studied, there is grow...
Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation [0.03%]
利用池和靶向单细胞激活精细剖析基因组调控图谱
Dubravka Vučićević,Che-Wei Hsu,Lorena Sofia Lopez Zepeda et al.
Dubravka Vučićević et al.
Enhancers are known to spatiotemporally regulate gene transcription, yet the identification of enhancers and their target genes is often indirect, low resolution, and/or assumptive. To identify and functionally perturb enhancers at their en...
Single-cell analysis of Barrett's esophagus and carcinoma reveals cell types conferring risk via genetic predisposition [0.03%]
单细胞分析发现遗传易感性介导食管巴雷特氏症和癌风险的细胞类型
Marten C Wenzel,Pouria Dasmeh,Patrick S Plum et al.
Marten C Wenzel et al.
Inherited genetic variants contribute to Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), but it is unknown which cell types are involved in this process. We performed single-cell RNA sequencing of BE, EAC, and paired normal ti...
Systematically investigating and identifying bacteriocins in the human gut microbiome [0.03%]
系统调查和鉴定人类肠道微生物组中的细菌素
Dengwei Zhang,Yinai Zou,Yuqi Shi et al.
Dengwei Zhang et al.
Human gut microbiota produces unmodified bacteriocins, natural antimicrobial peptides that protect against pathogens and regulate host physiology. However, current bioinformatic tools limit the comprehensive investigation of bacteriocins' b...
Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci [0.03%]
复杂遗传位点内源性精细定位和功能调控元件的优先排序
Ke Zhao,Yao Zhou,Xueqi Wang et al.
Ke Zhao et al.
Most genetic loci linked to polygenic traits are in non-coding regions, with complex regulation and linkage disequilibrium (LD), complicating causal variant and gene prioritization. We used multiplexed single-cell CRISPR interference and ac...