Group B streptococcal disease in infants 0-3 months in The Netherlands, 1987-2023: a nationwide genomic and epidemiological surveillance study [0.03%]
1987年至2023年荷兰新生儿（0-3个月）B群链球菌疾病：一项全国范围内的基因组和流行病学监测研究
Marleen A Groenveld,Dorota Jamrozy,Douwe H Visser et al.
Marleen A Groenveld et al.
Background: Group B Streptococcus (GBS) is the leading cause of sepsis and meningitis in infants. The molecular epidemiology and potential vaccine coverage of GBS disease in infants was assessed in the Netherlands over a ...
Lipid-Lowering Treatment in Familial Hypercholesterolaemia, 1996-2021: A Nationwide Study [0.03%]
丹麦1996年至2021年家族性高胆固醇血症的降脂治疗：一项全国性研究
Jacob Reeh,Anders Berg Wulff,Børge G Nordestgaard et al.
Jacob Reeh et al.
Background: In familial hypercholesterolaemia, early and intensive lipid-lowering treatment postpones coronary heart disease and death, effectively shown after introduction of statins and later ezetimibe and PCSK9 inhibit...
Efficacy and Safety Evidence Supporting Cancer Drug Approvals in Switzerland (2001-2020): A Meta-Analysis of Pivotal Randomised Controlled Trials [0.03%]
基于2001年至2020年瑞士批准的抗癌药物关键随机对照试验的功效和安全证据的荟萃分析
Parisa Rahimzadeh,Qiyu Li,Leonie Rudofsky et al.
Parisa Rahimzadeh et al.
Background: Randomised controlled trials (RCTs) with overall survival (OS) as the primary endpoint remain the gold standard for evaluating the efficacy and safety of new cancer therapies. However, increasing reliance on e...
Inequalities in childhood pneumococcal conjugate vaccine uptake in England before and after the change from a 2 + 1 to 1 + 1 schedule: a longitudinal study [0.03%]
英格兰肺炎球菌结合疫苗接种不平等现象加剧：基于纵向研究考察从2+1到1+0免疫程序转变前后的影响
Praise Ilechukwu,Daniel Hungerford,Neil French et al.
Praise Ilechukwu et al.
Background: Introducing pneumococcal conjugate vaccines (PCVs) into England's childhood immunisation schedule has reduced pneumococcal disease. Nonetheless, pneumococcal disease burden persists, including in young childre...
Georgios Paslakis
Georgios Paslakis
Long-term clinical and cost-effectiveness of a fully automated digital cognitive behavioural therapy for insomnia: 2-year follow-up of a single-blind, superiority, randomised controlled trial [0.03%]
全自动数字化失眠认知行为治疗的长期临床疗效和成本效益：优势随机对照试验的2年随访结果
Daniel Vethe,Zareen A Khan,Cecilie L Vestergaard et al.
Daniel Vethe et al.
Background: We evaluated the long-term clinical and cost-effectiveness of fully automated digital cognitive behavioural therapy for insomnia (dCBT-I) or online patient education (PE) in the Norwegian general population. ...
Personality and mental health as mediators linking childhood maltreatment to intimate partner violence victimization: a Mendelian randomization-direction of causation twin study [0.03%]
童年虐待与亲密伴侣暴力受害关系中人格和精神健康的中介作用：孟德尔随机化-因果方向双生子研究
Patrizia Pezzoli,Wikus Barkhuizen,Olakunle Oginni et al.
Patrizia Pezzoli et al.
Background: Childhood maltreatment elevates risk of later intimate partner violence (IPV) victimization, both major psychiatric risk factors. Personality and mental health have been proposed as mediators, but these pathwa...
Clinical outcomes and remission trajectories in obese and non-obese patients with severe asthma treated with biologics: a retrospective longitudinal cohort study from the Severe Asthma Network Italy (SANI) registry [0.03%]
生物制剂治疗肥胖和非肥胖的重度哮喘患者的临床结局及缓解情况：来自意大利重度哮喘网络(SANI)登记处的回顾性纵向队列研究
Danilo Di Bona,Giuseppe Di Gioia,Enrico Heffler et al.
Danilo Di Bona et al.
Background: Obesity is common in severe asthma and associated with poorer control, reduced lung function, and comorbidities. Registry data suggest that obesity may lessen biologic effectiveness, but findings are inconsist...
Psychiatric inpatient bed capacity and suicide mortality in Sweden: a nationwide ecological study [0.03%]
瑞典精神病住院床位数量与自杀率的生态学研究
Jonas Berge,Måns Gerle,Sara Lindström
Jonas Berge
Background: Suicide is a leading cause of premature mortality worldwide, but the impact of system-level mental health resources remains unclear despite the central role of psychiatric inpatient care and declining bed capa...
Fosfomycin versus ciprofloxacin for febrile neutropenia prophylaxis in high-risk haematological patients (FOVOCIP): a phase 3, open-label, multicentre, randomised, non-inferiority trial [0.03%]
高危血液系统恶性肿瘤患者发热性中性粒细胞减少症预防用磷霉素与环丙沙星的非劣效性多中心开放标签随机对照三期临床试验(FOVOCIP研究)
Ahinoa Fernández Moreno,Paula López de Ugarriza,Ana Julia González Huerta et al.
Ahinoa Fernández Moreno et al.
Background: Prophylaxis with fluoroquinolones in high-risk neutropenic patients is currently under scrutiny. The FOVOCIP study aimed to evaluate the efficacy and safety of fosfomycin compared to ciprofloxacin in this popu...