Real-World Psilocybin Therapy for Treatment-Resistant Depression: A Retrospective Observational Study [0.03%]
针对难治性抑郁症的现实世界中 psilocybin 治疗：一项回顾性观察研究
Johannes Jungwirth,Samuel Westenhöfer,Helena D Aicher et al.
Johannes Jungwirth et al.
Background: Psilocybin has demonstrated promising antidepressant effects in depression and treatment-resistant depression (TRD) in controlled clinical trials. However, its effectiveness and safety in real-world therapeuti...
Attention-Deficit/Hyperactivity Disorder in Children and Adults in England, 2000-2025: Recorded Prevalence and Diagnostic Trends in a Population-Based Observational Study Using Routinely Collected Primary Care Data [0.03%]
英格兰2000-2025年的儿童和成人注意缺陷多动障碍：基于人群的观察性研究，使用常规收集的初级保健数据得出的患病率和诊断趋势
Amber John,Gavin R Stewart,William Mandy et al.
Amber John et al.
Background: Over recent years, public awareness of ADHD has increased, alongside a rise in assessment referrals. There is urgent need for large-scale evidence on the prevalence and incidence of recorded ADHD to understand...
Clinical effectiveness of internet-delivered self-help Aacceptance and Commitment Therapy for family carers of people with dementia (iACT4CARERS): a multicentre, parallel, randomised controlled trial [0.03%]
家庭照护者互联网递送的自我帮助型认知行为疗法（iACT4CARERS）：一项多中心、平行、随机对照试验
Naoko Kishita,Rebecca L Gould,Mizanur Khondoker et al.
Naoko Kishita et al.
Background: As dementia prevalence rises globally, unpaid family carers provide most care and face high mental health risk. Existing psychological interventions offer limited benefit for anxiety in this population. We eva...
Clinical effectiveness of internet-delivered self-help Aacceptance and Commitment Therapy for family carers of people with dementia (iACT4CARERS): a multicentre, parallel, randomised controlled trial [0.03%]
基于互联网的自助导向的承诺治疗（iACT4CARERS）对痴呆患者照顾者的临床疗效：一项多中心、平行、随机对照试验
Naoko Kishita,Rebecca L Gould,Mizanur Khondoker et al.
Naoko Kishita et al.
Background: As dementia prevalence rises globally, unpaid family carers provide most care and face high mental health risk. Existing psychological interventions offer limited benefit for anxiety in this population. We eva...
Burden of Dementia in Europe, 1990-2023: a systematic analysis from the Global Burden of Disease Study 2023 [0.03%]
欧洲1990-2023年痴呆疾病负担：全球疾病负担研究2023系统分析报告
Daniele Urso,Emma Nichols,Stefano Giannoni-Luza et al.
Daniele Urso et al.
Background: Dementia is a leading cause of disability and mortality in Europe, yet no recent harmonised assessment has described its impact across the European Union (EU-27) and the WHO European Region. ...
Rebalancing innovation, affordability, and access for orphan drugs in the European Union [0.03%]
欧盟罕见病药物的平衡创新、可负担性和可及性问题
Hilde Stevens,Georges Siotis,Micael Castanheira et al.
Hilde Stevens et al.
Orphan drug policy in the European Union faces a double price-and-innovation gap: a small fraction of rare diseases receive important resources while the overwhelming majority are under- or un-researched, leaving most rare disease patients ...
Long-term adherence to glucose-lowering therapy and cardiovascular risk in type 2 diabetes: a nationwide cohort study [0.03%]
2 型糖尿病患者长期坚持降糖治疗与心血管风险的关联：全国队列研究
Lise B Nielsen,Andreas Bartholdy,Tri-Long Nguyen et al.
Lise B Nielsen et al.
Background: Type 2 diabetes is a major risk factor for cardiovascular disease, and reducing this excess risk is a central goal of clinical management. Sustained adherence to glucose-lowering medication is considered a key...
Predictors of suicide attempt recurrence after an index suicide attempt in Spain: a prospective multicentre cohort study [0.03%]
西班牙首发自杀未遂后重复自杀尝试的预测因素：一项前瞻性多中心队列研究
Víctor Pérez,Matilde Elices,Carlos Schmidt et al.
Víctor Pérez et al.
Background: Suicide attempts are a critical public health concern, with a high risk of recurrence after an index attempt. We aimed to identify predictors of suicide reattempt within 12 months. ...
Whole genome sequencing in cerebral palsy: a UK paediatric pilot study [0.03%]
全基因组测序在脑瘫中的应用：一项英国儿科试点研究
Thiloka E Ratnaike,Heather H Pierce,Alison J Coffey et al.
Thiloka E Ratnaike et al.
Background: Prior international studies indicate that 9-36% of people with cerebral palsy (CP) have a monogenic condition. However, the utility of whole genome sequencing (WGS) as a diagnostic tool for United Kingdom (UK)...
Artificial intelligence in the EU Safe Hearts Plan: prediction alone is not enough [0.03%]
欧盟“安全心脏计划”中的人工智能：预测不够，行动才行
Hannah van Kolfschooten,Georges Hattab,Franziska Bächler et al.
Hannah van Kolfschooten et al.
The European Commission's Safe Hearts Plan positions AI as a key tool for enhancing the prevention, diagnosis, and care of cardiovascular disease. Although AI presents significant opportunities, the Safe Hearts Plan may be overstating its i...