Prolonged CD38 targeting with felzartamab in antibody-mediated kidney transplant rejection: a biomarker-guided open-label phase 2 extension [0.03%]
一种针对移植物抗宿主病的新型CD38抗体FEL-Z在肾移植中的开放性II期延长期试验：生物标志物指导下的felzartamab延长治疗
Katharina A Mayer,Matthias Diebold,Eva V Schrezenmeier et al.
Katharina A Mayer et al.
Background: Antibody-mediated rejection (AMR) is a major cause of kidney transplant failure. The CD38 antibody felzartamab has been shown to reduce AMR activity, but recurrence after stopping treatment suggested a need fo...
Reducing self-stigma and supporting disclosure in adults with mental illness [0.03%]
降低自我污名化并支持精神疾病患者的病情披露行为
Nicola J Reavley,Amy J Morgan
Nicola J Reavley
Outcomes, prognostic factors, and the role of intracranial pressure monitoring in severe community-acquired bacterial meningitis: a multicenter retrospective cohort study [0.03%]
一项多中心回顾性队列研究：重症社区获得性细菌性脑膜炎的结局、预后因素和颅内压监测的作用
Cindy Poirier,Nicolas Terzi,Nicolas Roesch et al.
Cindy Poirier et al.
Background: Community-acquired bacterial meningitis remains associated with high mortality and neurological disability in critically ill adults. Contemporary data on outcomes in mechanically ventilated patients and on the...
Endolymphatic duct blockage for Ménière's disease: a double-blind, randomised controlled trial [0.03%]
梅尼埃病内淋巴囊阻塞手术的双盲随机对照试验
Annejet A Schenck,Raymond van de Berg,Thomas T A Peters et al.
Annejet A Schenck et al.
Background: Treatment for Ménière's disease remains a subject of debate. A surgical technique in which the endolymphatic duct is blocked was proposed as a new treatment modality for patients with intractable Ménière's...
Primary Human Papillomavirus Screening Versus Cytology for Detection of Cervical Intraepithelial Neoplasia Grade 2 or Higher in Poland: a Parallel-Group, Randomized Controlled Trial [0.03%]
人乳头瘤病毒初筛与细胞学检查在宫颈上皮内瘤变筛查中的对比研究：波兰的平行分组随机对照试验
Andrzej Nowakowski,Anna Macios,Patrycja Glinska et al.
Andrzej Nowakowski et al.
Background: 2025 European guidelines recommended transition from cytology to HPV-based cervical cancer screening. We compared both strategies in a pilot in Poland. ...
Safety and efficiency of peanut oral immunotherapy in preschool children with slow up-dosing and low maintenance dosing: a randomised controlled trial [0.03%]
学龄前儿童花生过敏口服免疫治疗慢增量及低维持剂量方案的安全性和有效性：随机对照试验
Susanna Klevebro,Carina Uhl,Jon Roald Konradsen et al.
Susanna Klevebro et al.
Background: Oral immunotherapy (OIT) is an emerging treatment for peanut allergy. A variety of protocols have been investigated, and accumulating evidence suggests that younger children may benefit from greater immune pla...
The case for primary prevention of obesity in the era of GLP-1 therapies [0.03%]
GLP-1疗法时代肥胖一级预防的必要性
Søren Holm,Manuel Tena-Sempere,Dimitrios Koutsouris et al.
Søren Holm et al.
Obesity rates continue to rise across Europe, driven by obesogenic environments shaped by food systems, urban design, socioeconomic inequalities, and commercial forces. The introduction of incretin-based pharmacotherapies like GLP-1 recepto...
From Target Engagement to Treatment Governance: The Evolving Role of Amyloid PET in Anti-Amyloid Therapy [0.03%]
从靶点参与度到治疗治理：淀粉样PET在抗淀粉样治疗中的角色演变
Massimo Filippi,Giordano Cecchetti,Alma Ghirelli et al.
Massimo Filippi et al.
The introduction of anti-amyloid monoclonal antibodies has shifted Alzheimer's disease care from diagnostic clarification alone to the problem of treatment governance. While lecanemab and donanemab have demonstrated amyloid reduction at the...
Preparing Europe for Recurrent Autochthonous Dengue Transmission: Public Health Implications and Preparedness Priorities [0.03%]
欧洲本土登革热再次传播的公共卫生影响及应对重点问题研究报告
Giuseppe Ippolito,Alimuddin Zumla
Giuseppe Ippolito
Towards HPV-Based Cervical Cancer Screening in Poland: Lessons From a Landmark Trial [0.03%]
基于HPV的宫颈癌筛查在波兰的发展：一项里程碑式试验的经验教训
Artur J Jakimiuk,Marcin Januszewski
Artur J Jakimiuk