In vivo gamete toxicology in the context of in vitro fertilization: a narrative review [0.03%]
辅助生殖背景下的体内配子毒理学：综述性文章
Morgan Orsolini,Jason Russack,Huey Huynh et al.
Morgan Orsolini et al.
IVF as a clinical method to surmount infertility has existed since the 1970s, and yet fertilization, embryo development, pregnancy, and live birth rates remain unacceptably low. Although a multitude of factors may contribute to stagnated su...
Promises and pitfalls of preimplantation genetic testing for polygenic disorders: a narrative review [0.03%]
多基因疾病植入前遗传学检测的机遇与挑战：叙述性文献回顾
Jaime A Roura-Monllor,Zachary Walker,Joel M Reynolds et al.
Jaime A Roura-Monllor et al.
Preimplantation genetic testing for polygenic disorders (PGT-P) has been commercially available since 2019. PGT-P makes use of polygenic risk scores for conditions which are multifactorial and are significantly influenced by environmental a...
Ana K Rosen Vollmar,Shruthi Mahalingaiah,Anne Marie Jukic
Ana K Rosen Vollmar
Some medical professional organizations have advocated for including the menstrual cycle as a vital sign in adolescence, but not in adulthood. However, documenting menstrual cycle patterns is not routine clinical or research practice. Vital...
Bronwyn S Bedrick,Laura Courtright,Jiahui Zhang et al.
Bronwyn S Bedrick et al.
Objective: To assess the current literature evaluating the epigenetics of endometriosis in humans. Evidence review: A systematic review...
Assisted Reproductive Technology or Infertility: What underlies adverse outcomes? Lessons from the Massachusetts Outcome Study of Assisted Reproductive Technology [0.03%]
辅助生殖技术还是不孕不育：什么导致了不良的结果？——来自麻省辅助生殖技术outcome研究的启示
Judy E Stern,Leslie V Farland,Sunah S Hwang et al.
Judy E Stern et al.
Numerous studies have demonstrated that assisted reproductive technology (ART: defined here as including only in vitro fertilization and related technologies) is associated with increased adverse pregnancy, neonatal, and childhood developme...
Phthalates in Albumin from Human Serum: Implications for Assisted Reproductive Technology [0.03%]
人血清白蛋白中的增塑剂：辅助生殖技术的潜在风险
Jennifer R Hughes,Sandra Soto-Heras,Charles H Muller et al.
Jennifer R Hughes et al.
Albumin, a vital protein in cell culture systems, is derived from whole blood or blood products. The culture of human gametes and developing embryos for assisted reproduction (ART) uses albumin of human origin. Human serum albumin (HSA) is ...
Shared genetics between nonobstructive azoospermia and primary ovarian insufficiency [0.03%]
无梗阻性无精子症与原发性卵巢功能不全之间的共有遗传因素
Lauren Verrilli,Erica Johnstone,Kristina Allen-Brady et al.
Lauren Verrilli et al.
Objective: Primary ovarian insufficiency (POI) and Non-obstructive azoospermia (NOA) both represent disease states of early, and often complete, failure of gametogenesis. Because oogenesis and spermatogenesis share the sa...
Uterine natural killer cell biology and role in early pregnancy establishment and outcomes [0.03%]
子宫自然杀伤细胞的生物学特性及其在妊娠早期建立和结局中的作用
Jessica R Kanter,Sneha Mani,Scott M Gordon et al.
Jessica R Kanter et al.
Objective: While immune cells were originally thought to only play a role in maternal tolerance of the semiallogenic fetus, an active role in pregnancy establishment is becoming increasingly apparent. Uterine natural kill...
The impact of coronavirus on reproduction: contraceptive access, pregnancy rates, pregnancy delay, and the role of vaccination [0.03%]
新型冠状病毒对生育的影响：避孕途径、妊娠率、延缓怀孕及疫苗的作用
Jasmine Aly,Lindsey Choi,Alicia Y Christy
Jasmine Aly
It is important to closely examine trends in reproduction during a pandemic because it provides not only the foundation for an improved future response but also crucial insights regarding the disparate impact across different races and soci...
Pardis Hosseinzadeh,Maya Barsky,William E Gibbons et al.
Pardis Hosseinzadeh et al.
Polycystic ovary syndrome (PCOS) is a common disorder that affects various facets of fertility. Although the ovarian and metabolic aspects of the disease is well studied, its role in uterine dysfunction is not well understood. Our objective...