Bioactive engineered scaffolds based on PCL-PEG-PCL and tumor cell-derived exosomes to minimize the foreign body reaction [0.03%]
基于PCL-PEG-PCL和肿瘤细胞源外泌体的工程支架以最小化异物反应
Zehong Xiang,Xinghua Guan,Zhifang Ma et al.
Zehong Xiang et al.
Long-term presence of M1 macrophages causes serious foreign body reaction (FBR), which is the main reason for the failure of biological scaffold integration. Inducing M2 polarization of macrophages near scaffolds to reduce foreign body resp...
Mechanoregulated trabecular bone adaptation: Progress report on in silico approaches [0.03%]
基于力学信号的骨小梁适应性研究：计算方法进展报告
Ekaterina Smotrova,Simin Li,Vadim V Silberschmidt
Ekaterina Smotrova
Adaptation is the process by which bone responds to changes in loading environment and modulates its properties and spatial organization to meet the mechanical demands. Adaptation in trabecular bone is achieved through increase in bone mass...
Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies [0.03%]
毒理学中的自然语言处理：界定不良结局途径和指导新方法的应用
Marie P F Corradi,Alyanne M de Haan,Bernard Staumont et al.
Marie P F Corradi et al.
Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiating event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide ther...
Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation [0.03%]
基于3D模型、微孔和标准化微流控平台的集成人体肝芯片构建及其药物评估支持的概念验证研究
Benoit Cox,Patrick Barton,Reiner Class et al.
Benoit Cox et al.
Human 3D liver microtissues/spheroids are powerful in vitro models to study drug-induced liver injury (DILI) but the small number of cells per spheroid limits the models' usefulness to study drug metabolism. In this work, we scale up the nu...
Antimicrobial-free graphene nanocoating decreases fungal yeast-to-hyphal switching and maturation of cross-kingdom biofilms containing clinical and antibiotic-resistant bacteria [0.03%]
无抗菌剂的石墨烯纳米涂层可减少临床耐药菌参与的跨物种黏膜菌群中真菌芽生-菌丝转变及成熟
Shruti Vidhawan Agarwalla,Kassapa Ellepola,Vitaly Sorokin et al.
Shruti Vidhawan Agarwalla et al.
Candida albicans and methicillin-resistant Staphylococcus aureus (MRSA) synergize in cross-kingdom biofilms to increase the risk of mortality and morbidity due to high resistance to immune and antimicrobial defenses. Biomedical devices and ...
Contraction pressure analysis using optical imaging in normal and MYBPC3-mutated hiPSC-derived cardiomyocytes grown on matrices with tunable stiffness [0.03%]
基于心肌细胞培养基板刚度调节的收缩压力分析及MYBPC3突变对其影响的光学成像研究
Matthijs Snelders,Iris H Koedijk,Julia Schirmer et al.
Matthijs Snelders et al.
Current in vivo disease models and analysis methods for cardiac drug development have been insufficient in providing accurate and reliable predictions of drug efficacy and safety. Here, we propose a custom optical flow-based analysis method...
Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model [0.03%]
快速分离软骨细胞与种子干细胞共培养的三层胶原蛋白基质支架在山羊骨软骨缺损模型中的评估研究
Tanya J Levingstone,Eamon J Sheehy,Conor J Moran et al.
Tanya J Levingstone et al.
Cartilage has poor regenerative capacity and thus damage to the joint surfaces presents a major clinical challenge. Recent research has focussed on the development of tissue-engineered and cell-based approaches for the treatment of cartilag...
Human endothelial cells form an endothelium in freestanding collagen hollow filaments fabricated by direct extrusion printing [0.03%]
由直接挤出印刷制造的独立胶原空心纤维形成人内皮细胞血管内皮细胞层
Ina Prade,Michaela Schröpfer,Caroline Seidel et al.
Ina Prade et al.
Fiber-shaped materials have great potential for tissue engineering applications as they provide structural support and spatial patterns within a three-dimensional construct. Here we demonstrate the fabrication of mechanically stable, meter-...
A quest for cytocompatible metal organic frameworks in non-viral gene therapy: Relevance of zeolitic imidazolate framework-8 [0.03%]
用于非病毒基因治疗的细胞兼容金属有机框架的研究：imidazolate框架8的相关性
A Poddar,S Pyreddy,S A Polash et al.
A Poddar et al.
Metal-organic frameworks (MOFs) are an emerging group of nanomaterials for successful biomedical applications in gene therapy. The most commonly biocompatible MOFs are zinc-based ZIFs, zirconium-based UiOs, and iron-based MILs. However, des...
Neural progenitor cell-derived extracellular matrix as a new platform for neural differentiation of human induced pluripotent stem cells [0.03%]
人诱导多能干细胞神经分化的新型平台：神经前体细胞源性胞外基质
Marta S Carvalho,Diogo E S Nogueira,Joaquim M S Cabral et al.
Marta S Carvalho et al.
The culture microenvironment has been demonstrated to regulate stem cell fate and to be a crucial aspect for quality-controlled stem cell maintenance and differentiation to a specific lineage. In this context, extracellular matrix (ECM) pro...