Growth factor and macromolecular crowding supplementation in human tenocyte culture [0.03%]
人腱细胞培养中的生长因子及大分子拥挤效应补充
Dimitrios Tsiapalis,Stephen Kearns,Jack L Kelly et al.
Dimitrios Tsiapalis et al.
Cell-assembled tissue engineering strategies hold great potential in regenerative medicine, as three-dimensional tissue-like modules can be produced, even from a patient's own cells. However, the development of such implantable devices requ...
Biomaterials enhancing performance of cell and nucleic-acid therapies: An opportunity in the brain [0.03%]
用于细胞和核酸治疗的生物材料增强型脑部疗法的机会
Christopher Lally,Kieran Joyce,Abhay Pandit
Christopher Lally
The brain has limited innate ability to promote repair, regeneration and functional recovery following injury, disease, or developmental disorder. Although cell and gene therapies have significant potential in the brain, no single treatment...
Development of decellularization protocol for caprine small intestine submucosa as a biomaterial [0.03%]
用于制备山羊小肠粘膜下层组织工程移植物的脱细胞方法学研究
Hemant Singh,Shiv Dutt Purohit,Rakesh Bhaskar et al.
Hemant Singh et al.
Decellularized animal tissues have been proven to be promising biomaterials for various tissue engineering (TE) applications. Among various animal tissues, small intestine submucosa (SIS) has gained attention of many researchers due to its ...
Amorphous calcium phosphate, the lack of order is an abundance of possibilities [0.03%]
无定形钙磷酸盐：缺乏有序，丰富的可能
Lorenzo Degli Esposti,Michele Iafisco
Lorenzo Degli Esposti
For almost three decades from its discovery, amorphous calcium phosphate (ACP) was not considered a suitable biomaterial due to its structural instability. Thanks to its unique properties in respect to crystalline calcium phosphate phases, ...
Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles [0.03%]
spacer长度和血清蛋白吸附影响曲妥珠单抗修饰的纳米粒的靶向性
Christina Barth,Hendrik Spreen,Dennis Mulac et al.
Christina Barth et al.
Receptor-mediated active targeting of nanocarriers is a widely investigated approach to specifically address cancerous cells and tissues in the human body. The idea is to use these formulations as drug carriers with enhanced specificity and...
Magnetic CuFe2O4 with intrinsic protease-like activity inhibited cancer cell proliferation and migration through mediating intracellular proteins [0.03%]
具有类蛋白酶活性的磁性CuFe₂O₄通过介导胞内蛋白抑制癌细胞增殖和迁移
Daomei Chen,Liang Jiang,Tao Lei et al.
Daomei Chen et al.
Protease has been widely used in biological and industrial fields. Developing efficient artificial enzyme mimics remains a major technical challenge due to the high stability of peptide bonds. Nanoenzymes with high stability, high activity ...
Cell engineering techniques improve pharmacology of cellular therapeutics [0.03%]
细胞工程技术提高细胞治疗药物的作用效果
Kaini Liang,Yanan Du
Kaini Liang
Despite the rapid growth of clinical trials for cellular therapy worldwide, their clinical success is still afflicted with formidable challenges demanding conceptual and technological overhaul. Pharmacology, which is conventionally divided ...
Current interpretations on the in vivo response of bone to additively manufactured metallic porous scaffolds: A review [0.03%]
基于文献的论点：增材制造金属多孔支架在体骨响应的当前解释综述
Joseph Deering,Kathryn Grandfield
Joseph Deering
Recent advances in the field of metallic additive manufacturing have expanded production capabilities for bone implants to include porous lattice structures. While traditional models of de novo bone formation can be applied to fully dense i...
Current good manufacturing practice considerations for mesenchymal stromal cells as therapeutic agents [0.03%]
间充质基质细胞作为治疗剂的现行良好制造规范考量因素
Clara Sanz-Nogués,Timothy O&#x;Brien
Clara Sanz-Nogués
Producing human mesenchymal stromal cells (MSCs) for clinical use requires adherence to current good manufacturing practice (cGMP) standards. This is necessary for ensuring standardization and reproducibility through the manufacturing proce...
Hasan Uludağ,Tian Tang
Hasan Uludağ
Molecular Dynamics (MD) simulations can provide a glimpse of complex atomistic and molecular events at the interface of biomaterials and biosystems. Gene therapy efforts that deploy biomaterial mediated delivery of nucleic acids could benef...