The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis [0.03%]
炎症介质和基质金属蛋白酶(MMP)在骨关节炎的发病过程中所起的作用
Anwesha Mukherjee,Bodhisatwa Das
Anwesha Mukherjee
Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance between (synthesis) and catabolism (degradation) in altered homeostasis of articular cartilage mediated primarily by the innate immune system. OA degene...
Yann D Ladner,Martin J Stoddart
Yann D Ladner
Novel cartilage regeneration therapies often look promising in-vitro but fail when implanted in vivo. One of the possible reasons for this discrepancy is the simplified, static in-vitro chondrogenesis models typically used. Complex mechanic...
3D printed hybrid scaffolds do not induce adverse inflammation in mice and direct human BM-MSC chondrogenesis in vitro [0.03%]
3D打印的混合支架不对小鼠产生不良炎症，并且在体外引导人骨髓间充质干细胞的软骨发生分化
Silvia A Ferreira,Francesca Tallia,Agathe Heyraud et al.
Silvia A Ferreira et al.
Biomaterials that can improve the healing of articular cartilage lesions are needed. To address this unmet need, we developed novel 3D printed silica/poly(tetrahydrofuran)/poly(ε-caprolactone) (SiO2/PTHF/PCL-diCOOH) hybrid scaffolds. Our a...
3D printed bioabsorbable composite scaffolds of poly (lactic acid)-tricalcium phosphate-ceria with osteogenic property for bone regeneration [0.03%]
具有成骨作用的聚乳酸-磷酸三钙-铈复合三维打印生物可吸收支架用于骨再生
Samarah V Harb,Elayaraja Kolanthai,Abinaya S Pugazhendhi et al.
Samarah V Harb et al.
The fabrication of customized implants by additive manufacturing has allowed continued development of the personalized medicine field. Herein, a 3D-printed bioabsorbable poly (lactic acid) (PLA)- β-tricalcium phosphate (TCP) (10 wt %) comp...
Rise of tissue- and species-specific 3D bioprinting based on decellularized extracellular matrix-derived bioinks and bioresins [0.03%]
基于脱细胞基质生物墨水和生物树脂的组织特异性及物种特异性三维生物打印技术的发展
Laura Elomaa,Ahed Almalla,Eriselda Keshi et al.
Laura Elomaa et al.
Thanks to its natural complexity and functionality, decellularized extracellular matrix (dECM) serves as an excellent foundation for creating highly cell-compatible bioinks and bioresins. This enables the bioprinted cells to thrive in an en...
Optimization and evaluation of oxygen-plasma-modified, aligned, poly (Є-caprolactone) and silk fibroin nanofibrous scaffold for corneal stromal regeneration [0.03%]
氧等离子体改性聚-ε-己内酯/丝素蛋白纳米纤维支架的优化及角膜基质再生评估研究
Promita Bhattacharjee,Peter W Madden,Enzo Patriarca et al.
Promita Bhattacharjee et al.
The shortage of human donor corneas for transplantation necessitates the exploration of tissue engineering approaches to develop corneal substitutes. However, these substitutes must possess the necessary strength, transparency, and ability ...
Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation [0.03%]
理化刺激不是人真皮成纤维细胞转分化的有效调节因子
Christina N M Ryan,Eugenia Pugliese,Naledi Shologu et al.
Christina N M Ryan et al.
Due to their inherent plasticity, dermal fibroblasts hold great promise in regenerative medicine. Although biological signals have been well-established as potent regulators of dermal fibroblast function, it is still unclear whether physioc...
Biomaterials are the key to unlock spheroid function and therapeutic potential [0.03%]
生物材料是解锁类器官功能和治疗潜力的关键
David H Ramos-Rodriguez,J Kent Leach
David H Ramos-Rodriguez
Spheroids are three-dimensional cell aggregates that mimic fundamental aspects of the native tissue microenvironment better than single cells, making them a promising platform for the study of tissue development and therapeutics. Spheroids ...
Disruptive 3D in vitro models for respiratory disease investigation: A state-of-the-art approach focused on SARS-CoV-2 infection [0.03%]
用于呼吸系统疾病研究的破坏性体外三维模型：针对SARS-CoV-2感染的最新方法
Maria Luiza Seixas,Cynthia Silva Bartolomeo,Robertha Lemes et al.
Maria Luiza Seixas et al.
COVID-19, along with most respiratory diseases in the medical field, demonstrates significant ability to take its toll on global population. There is a particular difficulty in studying these conditions, which stems especially from the shor...
Electrospun decellularized extracellular matrix scaffolds promote the regeneration of injured neurons [0.03%]
静电纺脱细胞基质支架促进损伤神经元再生
Lena Mungenast,Ronya Nieminen,Carine Gaiser et al.
Lena Mungenast et al.
Traumatic injury to the spinal cord (SCI) causes the transection of neurons, formation of a lesion cavity, and remodeling of the microenvironment by excessive extracellular matrix (ECM) deposition and scar formation leading to a regeneratio...