Advancements in nanomedicines for the detection and treatment of diabetic kidney disease [0.03%]
纳米医药在糖尿病肾病检测和治疗中的进展
Luke Tillman,Tanveer A Tabish,Nazila Kamaly et al.
Luke Tillman et al.
In the diabetic kidneys, morbidities such as accelerated ageing, hypertension and hyperglycaemia create a pro-inflammatory microenvironment characterised by extensive fibrogenesis. Radiological techniques are not yet optimised generating in...
Bioengineered PLEKHA7 nanodelivery regularly induces behavior alteration and growth retardation of acute myeloid leukemia [0.03%]
生物工程PLEKHA7纳米载体定期诱导急性髓系白血病行为改变和生长迟缓
Sameh A Mohammed,Yasuhiro Kimura,Yuhki Toku et al.
Sameh A Mohammed et al.
Acute myeloid leukemia (AML) is the most lethal leukemia with an extremely poor prognosis and high relapse rates. In leukemogenesis, adhesion abnormalities can readily guide an imbalance between hematopoietic progenitor cells and bone marro...
Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations [0.03%]
鼓膜穿孔修复的组织工程和再生医学策略
Elizabeth Sainsbury,Ronaldo do Amaral,Alexander W Blayney et al.
Elizabeth Sainsbury et al.
Despite the high success rate of autologous grafts in tympanic membrane repair, clinical alternatives are required for the closure of unresponsive chronic perforations that can lead to recurring infection and hearing loss. Tissue engineerin...
Matthew J Webber
Matthew J Webber
Biomaterials offer elegant frameworks to uncover mysteries of biology and vital tools to treat diseased or damaged tissues. Complex natural materials in the living world inspire the design of many engineered biomaterial constructs. Yet, com...
Endothelial barrier function is co-regulated at vessel bifurcations by fluid forces and sphingosine-1-phosphate [0.03%]
流体力量和鞘氨醇-1-磷酸在血管分支处共同调节内皮屏障功能
Ehsan Akbari,Griffin B Spychalski,Miles M Menyhert et al.
Ehsan Akbari et al.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid mediator of endothelial barrier function. Prior studies have implicated mechanical stimulation due to intravascular laminar shear stress in co-regulating S1P signaling in endothelial...
Engineered extracellular vesicles antagonize SARS-CoV-2 infection by inhibiting mTOR signaling [0.03%]
工程化细胞外囊泡通过抑制mTOR信号通路拮抗SARS-CoV-2感染
A G Ibrahim,A Ciullo,C Li et al.
A G Ibrahim et al.
Effective treatment approaches for patients with COVID-19 remain limited and are neither curative nor widely applicable. Activated specialized tissue effector extracellular vesicles (ASTEX) derived from genetically-enhanced skin fibroblasts...
Proof-of-concept trial of an amniotic fluid-derived extracellular vesicle biologic for treating high risk patients with mild-to-moderate acute COVID-19 infection [0.03%]
源自羊水的细胞外囊泡生物制剂治疗高风险轻中度急性COVID-19感染患者的概念验证试验
Michael A Bellio,Cassie Bennett,Alissa Arango et al.
Michael A Bellio et al.
A pandemic brought on by COVID-19 has created a scalable health crisis. The search to help alleviate COVID-19-related complications through therapeutics has become a necessity. Zofin is an investigational, acellular biologic derived from fu...