Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro [0.03%]
有关体外生物工程组织的台式流体流动生物反应器的设计考虑因素
H W Hoyle,C M L Stenger,S A Przyborski
H W Hoyle
One of the major aims of bio-engineering tissue equivalents in vitro is to create physiologically relevant culture conditions to accurately recreate the cellular microenvironment. This often includes incorporation of factors such as the ext...
Polycaprolactone-collagen nanofibers loaded with dexamethasone and simvastatin as an osteoinductive and immunocompatible scaffold for bone regeneration applications [0.03%]
一种用于骨组织工程的成骨诱导及免疫兼容性支架：负载地塞米松和辛伐他汀的聚己内酯-胶原纳米纤维
Hilal Ahmad Rather,Johnna Francis Varghese,Bindiya Dhimmar et al.
Hilal Ahmad Rather et al.
Physiological inflammation has been shown to promote bone regeneration; however, prolonged inflammation impedes the osteogenesis and bone repair process. To overcome the latter we aimed to develop a dual drug delivering nanofibrous scaffold...
Polymeric siRNA delivery targeting integrin-β1 could reduce interactions of leukemic cells with bone marrow microenvironment [0.03%]
聚丙烯酸siRNA递送靶向整合素-β1能减少白血病细胞与骨髓微环境的相互作用
Daniel Nisakar Meenakshi Sundaram,Cezary Kucharski,Remant Bahadur Kc et al.
Daniel Nisakar Meenakshi Sundaram et al.
Uncontrolled proliferation of the myeloid cells due to BCR-ABL fusion has been successfully treated with tyrosine kinase inhibitors (TKIs), which improved the survival rate of Chronic Myeloid Leukemia (CML) patients. However, due to interac...
Biodegradable nanoparticulate co-delivery of flavonoid and doxorubicin: Mechanistic exploration and evaluation of anticancer effect in vitro and in vivo [0.03%]
可降解纳米颗粒共输送黄酮类和阿霉素：机制研究及体内外抗肿瘤效果评估
Iliyas Khan,Bibekananda Sarkar,Gaurav Joshi et al.
Iliyas Khan et al.
The proposed study involves delivering drug/bioactive using a single nanoplatform based on poly lactic-co-glycolic acid (PLGA) for better efficacy, synergistic effect, and reduced toxicity. PLGA was conjugated to doxorubicin (D1), and this ...
Mitochondria-targeted nanoparticles (mitoNANO): An emerging therapeutic shortcut for cancer [0.03%]
线粒体靶向型纳米颗粒（简称“线粒体纳米药物”）：治疗癌症的新途径
Tanveer A Tabish,Michael R Hamblin
Tanveer A Tabish
The early understanding of mitochondria posited that they were 'innocent organelles' solely devoted to energy production and utilisation. Intriguingly, recent findings have outlined in detail the 'modern-day' view that mitochondria are an i...
Helena S Azevedo,Alvaro Mata
Helena S Azevedo
Animate materials, man-made materials behaving like living systems, are attracting enormous interest across a range of sectors, from construction and transport industry to medicine. In this leading opinion article, we propose that embracing...
Vascular tissue engineering from human adipose tissue: fundamental phenotype of its resident microvascular endothelial cells and stromal/stem cells [0.03%]
人脂肪组织血管组织工程：其居民微血管内皮细胞和间充质/干细胞的基本表型研究
Jeremy A Antonyshyn,Meghan J McFadden,Anthony O Gramolini et al.
Jeremy A Antonyshyn et al.
Adipose tissue is an abundant, accessible, and uniquely dispensable source of cells for vascular tissue engineering. Despite its intrinsic endothelial cells, considerable effort is directed at deriving endothelium from its resident stem and...
Application of bioengineered elastin-like polypeptide-based system for targeted gene delivery in tumor cells [0.03%]
生物工程弹性蛋白多肽系统在肿瘤细胞靶向基因递送中的应用研究
Aena Yi,Dahye Sim,Seon-Boon Lee et al.
Aena Yi et al.
Successful gene delivery depends on the entry of negatively charged DNAs and oligonucleotides across the various barriers of the tumor cells and localization into the nucleus for its transcription and protein translation. Here, we have repo...
Comparison of human amniotic membrane and collagen nerve wraps around sciatic nerve reverse autografts in a rat model [0.03%]
人羊膜与胶原神经导管包裹坐骨神经自体移植的比较研究小鼠模型中的应用
Erin M Wolfe,Sydney A Mathis,Natalia de la Olivo Muñoz et al.
Erin M Wolfe et al.
Human amniotic membrane (hAM) and collagen nerve wraps are biomaterials that have been investigated as therapies for improving outcomes of peripheral nerve regeneration; however, their efficacy has not been compared. The purpose of this stu...
3D printed scaffolds: Challenges toward developing relevant cellular in vitro models [0.03%]
用于相关细胞体外模型的3D打印脚手架：面临的挑战
Beatriz Molina-Martínez,Luis M Liz-Marzán
Beatriz Molina-Martínez
Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology. Promising microphysiological systems have been fabricated by combi...