VRON-0200 alone and in combination with investigational antivirals for participants with chronic hepatitis B virus infection receiving stable nucleos(t)ide therapy: a phase 1b, randomised, open-label, multicentre trial [0.03%]
一种用于治疗慢性乙肝病毒感染并接受稳定核苷[酸]治疗受试者的研究性抗病毒药物VRON-0200的单药疗法及其与其它研究性抗病毒药物联用疗法：一项开放标签、多中心1b期随机试验
Edward Gane,Grace Lai-Hung Wong,Sue Currie et al.
Edward Gane et al.
Background: Functional cure treatments for hepatitis B virus (HBV) have been restricted by their inability to restore anti-HBV immunity, often leading to viral rebound after treatment. VRON-0200 is a novel immunotherapy f...
Rethinking airborne transmission risk of monkeypox virus: a methodological perspective on quantitative PCR threshold collapse in environmental air sampling [0.03%]
猴痘病毒空气传播风险的再思考——环境空气中定量PCR阈值塌缩的方法学视角
Zhaoliang Chen,Juxiang Liu,Zhendong Guo
Zhaoliang Chen
From microbiomes to predictive ecosystems: challenges and opportunities in artificial intelligence-based approaches [0.03%]
从微生物组到预测生态系统：基于人工智能方法的挑战和机遇
Wanqian Yu,Hua Qu,Shaopu Wang et al.
Wanqian Yu et al.
Microbiome systems encompass diverse ecological niches and host associations, with their scale and complexity challenging traditional analytical frameworks. Advances in artificial intelligence are transforming microbiome research by enablin...
Project ODIN: advancing environmental genomic surveillance for public health across sub-Saharan Africa [0.03%]
项目ODIN：在撒哈拉以南非洲推进环境基因组监测以促进公共卫生
Bonny Baker,José Antonio Baz Lomba,Joseph Bitilinyu-Bangoh et al.
Bonny Baker et al.
Persistent SARS-CoV-2 transmission, ongoing mpox outbreaks, and the continued spread of endemic diseases such as typhoid fever and cholera underscore the urgent need for global, multiomics surveillance. In this Personal View, we present Pro...
Upsurge of pneumococcal clade I-α/CC180 serotype 3 and its association with a LytA mutation linked to immune evasion and disease potential: an observational and experimental study [0.03%]
血清型3肺炎链球菌支系I-α/CC180的流行及其与免疫逃逸和致病性相关LytA突变体的关联：观察性和实验性研究
Covadonga Pérez-García,Julio Sempere,Mirella Llamosí et al.
Covadonga Pérez-García et al.
Background: Streptococcus pneumoniae serotype 3 is one of the most prevalent serotypes that cause invasive pneumococcal disease (IPD) in children and adults worldwide. Serotype 3 is associated with vaccine failures and br...
Improving prediction of future Mycoplasma pneumoniae epidemics using data-driven transmission models [0.03%]
利用数据驱动的传播模型提高对未来肺炎支原菌流行病预测的准确性
Xu-Sheng Zhang,Semjon Sidorov,Ursula Dalrymple et al.
Xu-Sheng Zhang et al.
Gene transfer from NDM-5-producing and OXA-48-producing Enterobacter hormaechei ST79 on contaminated dicloxacillin capsules to other Enterobacterales in Europe, 2020-23: a retrospective, observational, molecular epidemiological study [0.03%]
欧洲污染头孢西丁胶囊的肠杆菌科ST79产NDM-5和OXA-48型基因转移至其他肠杆菌：2020年-2023年的回顾性观察分子流行病学研究
Astrid Rasmussen,Lone J Porsbo,Louise Roer et al.
Astrid Rasmussen et al.
Background: In February, 2023, an outbreak of Enterobacter hormaechei ST79 carrying blaNDM-5 and blaOXA-48 was linked to contaminated dicloxacillin capsules administered to approximately 79 000 individuals in Denmark. Ini...
Spatially resolved architecture of the human gut microbiome and its health implications [0.03%]
人体肠道微生物组的空间构型及其对人体健康的影响
Shaopu Wang,Alexandre Almeida,Dezhi Mu et al.
Shaopu Wang et al.
The human gut microbiome shows dynamic variation throughout the lifespan and remarkable spatial organisation within the gastrointestinal tract. Complementing the focus of the first paper of this Series on the human microbiome dynamics and h...
Shuqin Zeng,Alexandre Almeida,Dezhi Mu et al.
Shuqin Zeng et al.
The colonisation of the human gut microbiome commences at birth and continues to evolve throughout the lifespan. A balanced symbiotic relationship between the host and gut microbiome is essential for maintaining overall health. This two-par...
The Lancet Microbe
The Lancet Microbe