Genotype-based antimicrobial resistance tests need a new regulatory framework [0.03%]
基因型抗菌药物耐药检测需要新的监管框架
Yonatan H Grad,Daniel B Larremore,Marc Lipsitch
Yonatan H Grad
Evaluation of the effectiveness of artemether-lumefantrine and artesunate-pyronaridine each combined with single low-dose primaquine in adults with Plasmodium falciparum infection in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial [0.03%]
青蒿琥酯-派罗纳林和 Arteharlitin-Lumefantrine 联合伯氨喹单剂低剂量治疗埃塞俄比亚成年人感染的疗效：一项 II/III 期、观察者设盲、随机对照平行组试验
Migbaru Keffale Bezabih,Tadesse Misganaw,Legesse Alamerie Ejigu et al.
Migbaru Keffale Bezabih et al.
Background: Plasmodium falciparum parasites carrying the pfkelch13 R622I variant, associated with artemisinin resistance, are prevalent in the Horn of Africa. These parasites can also harbour histidine rich protein 2/3 (p...
Widespread circulation of Alongshan virus in Austria and serological evidence for infection in humans: a nationwide molecular and serological observational study [0.03%]
沿山病毒在奥地利的广泛传播及人类感染的血清学证据：一项全国性的分子和血清学观察研究
David M Florian,Paul Jetzinger,Anna-Margarita Schötta et al.
David M Florian et al.
Background: Alongshan virus, a segmented RNA virus in the Jingmenvirus group of flaviviruses, was first identified in 2017 in China in patients with tick-borne encephalitis-like illness. Alongshan virus has since been det...
Efficacy of chloroquine plus low-dose primaquine and pyronaridine-artesunate plus low-dose primaquine against Plasmodium vivax malaria in adults and transmission to mosquitoes in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial [0.03%]
氯喹联合小剂量伯氨喹和派沙珠氯喹联合小剂量伯氨喹对埃塞俄比亚成人患者间日疟的疗效及传播阻断效果：一项II期和III期观察掩蔽、随机平行组试验
Migbaru Keffale Bezabih,Solomon Sisay,Sinknesh Wolde Behaksera et al.
Migbaru Keffale Bezabih et al.
Background: In areas co-endemic for Plasmodium vivax and Plasmodium falciparum, artemisinin-based combination therapy is being considered as unified treatment strategy. The clinical and transmission-reducing efficacy of a...
Accuracy of rapid diagnostic tests for Strongyloides stercoralis detection: a systematic review and meta-analysis [0.03%]
用于检测丝虫病的快速诊断试验的准确性：系统评价和meta分析
Francesca Tamarozzi,Maria Luca D&#x;Errico,Andrea V Fittipaldo et al.
Francesca Tamarozzi et al.
Background: Strongyloidiasis is a widely distributed, potentially fatal, neglected parasitic disease caused by the soil-transmitted helminth Strongyloides stercoralis. WHO has recently issued the target product profile (T...
Diversity analysis of indoor and outdoor fungal bioaerosols in UK households: a prospective, observational, longitudinal study [0.03%]
英国家庭室内及室外真菌生物气溶胶多样性分析：一项前瞻性观察性研究
Samuel J Hemmings,Diana Varaden,Jessica Barnes et al.
Samuel J Hemmings et al.
Background: Long-term exposure to indoor fungal bioaerosols is a recognised risk factor for respiratory illness, particularly in damp and poorly ventilated housing. However, the diversity and seasonal variability of these...
Antimicrobial susceptibility patterns of Neisseria gonorrhoeae across anatomical sites within and between individuals in the Netherlands: a retrospective observational study [0.03%]
荷兰奈梅亨市淋病奈瑟菌的抗菌药敏感性模式：一项回顾性观察研究
Maartje Visser,Petra F G Wolffs,Christian J P A Hoebe et al.
Maartje Visser et al.
Background: Pharyngeal gonococcal infections are likely to contribute to the development of antimicrobial resistance (AMR) because of suboptimal efficacy of antibiotics in the pharynx, gene transfer with commensal Neisser...
Paul Adepoju
Paul Adepoju
Regional and temporal trends in antimicrobial susceptibility among isolates from bacterial keratitis: a systematic review and meta-analysis [0.03%]
角膜炎病原菌耐药的地区及时间分布特征：系统评价和meta分析
Stephen Tuft,Elliott H Taylor,Keri McLean et al.
Stephen Tuft et al.
Background: Bacterial keratitis is an important cause of preventable vision loss worldwide. In this study, we aimed to synthesise the evidence for regional and temporal differences in antimicrobial resistance that could i...
Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France [0.03%]
法国多中心观察性研究中呼吸道合胞病毒(B型)突破感染导致nirsevimab抗性的现实世界情况研究报告
Slim Fourati,Alawiya Reslan,Jérôme Bourret et al.
Slim Fourati et al.
Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in infants. Nirsevimab, a long-acting monoclonal antibody targeting a conserved epitope on the prefusion F protein (sit...