Nirmatrelvir-ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022-23: virological and immunological results of an open-label randomised trial (PANORAMIC) [0.03%]
2022至2023年英国高危成人中早期感染SARS-CoV-2的患者使用奈玛特韦-利托那韦与标准治疗对照：一项开放标签随机试验（“全景”研究）的病毒学和免疫学结果
David M Lowe,Shengyuan Zhang,Samuel Ellis et al.
David M Lowe et al.
Background: Nirmatrelvir-ritonavir is widely used for COVID-19, but effectiveness was established in unvaccinated people with SARS-CoV-2 variants before omicron. Within the randomised Platform Adaptive Trial of Novel Anti...
Talha Burki
Talha Burki
Evaluation of antigen and antibody assays for surveillance of Lassa virus in peri-domestic rodents in southeastern Sierra Leone: a cross-sectional study [0.03%]
利萨拉病毒监测的抗原和抗体测定在塞拉利昂东南部家栖啮齿动物中的横断面研究评估
Allison R Smither,James Koninga,Franklyn B Kanneh et al.
Allison R Smither et al.
Background: Lassa fever, caused by Lassa mammarenavirus (LASV), is a rodent-borne disease endemic to west Africa. Zoonotic surveillance of LASV provides epidemiological insights into its potential presence. We aimed to as...
Characterisation of immune responses targeting highly pathogenic avian influenza A(H5) viruses in health-care workers in the Netherlands: an observational, cross-sectional analysis [0.03%]
荷兰针对高致病性甲型流感病毒(A(H5))感染医护人员的免疫反应特征分析：横断面观察研究
Mark A Power,Willemijn F Rijnink,Widia Soochit et al.
Mark A Power et al.
Background: Highly pathogenic avian influenza A(H5) viruses pose a pandemic threat, with a history of mammalian adaptation and zoonotic spillovers into humans. We aimed to determine whether pre-existing cross-reactive imm...
Physiological peristaltic-like reactions of the tracheobronchial tree move pulmonary Mycobacterium tuberculosis bacilli into the gastrointestinal tract [0.03%]
生理蠕动样反应可将肺内结核分枝杆菌移动至胃肠道中
Andrew R DiNardo,George W Kasule,Alberto L Garcia-Basteiro;StoolTB Global Partnership
Andrew R DiNardo
Classification and sequencing of hepatitis D virus from a large cohort of chronically infected individuals paired with co-infecting hepatitis B virus sequencing: a genomic characterisation study [0.03%]
一项针对大量慢性感染患者的基因组特征研究：与共感染的乙肝病毒测序相配对的丁型肝炎病毒分类和排序
Savrina Manhas,Silvia Chang,Ross Martin et al.
Savrina Manhas et al.
Background: The most severe form of viral hepatitis is caused by co-infection of hepatitis D virus (HDV) and hepatitis B virus (HBV). Phylogenetic analyses classify HBV and HDV into eight major genotypes: HBV GTA to GTH a...
The Lancet Microbe
The Lancet Microbe
Timothy Jesudason
Timothy Jesudason
WHO assessment of the preclinical antifungal pipeline: evaluating innovation and preparedness in the face of emerging fungal threats [0.03%]
世卫组织评估抗真菌药临床前药物管道：面对新出现的真菌威胁评估创新和准备情况
Valeria Gigante,Richard A Alm,Tamarie Rocke et al.
Valeria Gigante et al.
Life-threatening invasive and mucosal fungal infections are a major, increasingly complex global health problem. Among all population groups, individuals who are immunocompromised face the greatest risk of contracting such infections, and t...
Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis [0.03%]
一项关于女性阴道菌群失调的双盲随机对照试验：无需使用抗生素进行阴道微生物移植治疗
Tine Wrønding,Kilian Vomstein,Agnete Troen Lundgaard et al.
Tine Wrønding et al.
Background: A vaginal microbiota dominated by Lactobacillus species is associated with reduced risk of infection and adverse reproductive outcomes. Effective interventions to restore healthy microbiota remain scarce. In t...
Randomized Controlled Trial
The Lancet. Microbe. 2026 Apr;7(4):101294. DOI:10.1016/j.lanmic.2025.101294 2026