Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate [0.03%]
利用脑脊液 transcerebral 压力和流量之间的相位差量化特发性正常压力脑积水的脑脊液动力学异常程度
Pragalv Karki,Stephanie Sincomb,Matthew C Murphy et al.
Pragalv Karki et al.
Background and purpose: Idiopathic normal pressure hydrocephalus (iNPH) is a cerebrospinal fluid (CSF) dynamics disorder as evidenced by the delayed ascent of radiotracers over the cerebral convexity on radionuclide ciste...
Effects of stress-dependent growth on evolution of sulcal direction and curvature in models of cortical folding [0.03%]
基于生长应力的脑皮层折叠模型中沟的方向和曲率的数值模拟研究
Ramin Balouchzadeh,Philip V Bayly,Kara E Garcia
Ramin Balouchzadeh
The majority of human brain folding occurs during the third trimester of gestation. Although many studies have investigated the physical mechanisms of brain folding, a comprehensive understanding of this complex process has not yet been ach...
Post-mortem changes of anisotropic mechanical properties in the porcine brain assessed by MR elastography [0.03%]
基于磁共振弹性成像的离体猪脑各向异性机械特性的时间变化研究
Shuaihu Wang,Kevin N Eckstein,Charlotte A Guertler et al.
Shuaihu Wang et al.
Knowledge of the mechanical properties of brain tissue in vivo is essential to understanding the mechanisms underlying traumatic brain injury (TBI) and to creating accurate computational models of TBI and neurosurgical simulation. Brain whi...
Neuroimaging, wearable sensors, and blood-based biomarkers reveal hyperacute changes in the brain after sub-concussive impacts [0.03%]
神经影像、可穿戴传感器和血液生物标志物揭示亚脑震荡冲击后大脑的超急性变化
Carissa Grijalva,Veronica A Mullins,Bryce R Michael et al.
Carissa Grijalva et al.
Impacts in mixed martial arts (MMA) have been studied mainly in regard to the long-term effects of concussions. However, repetitive sub-concussive head impacts at the hyperacute phase (minutes after impact), are not understood. The head exp...
Predicting the spatio-temporal response of recurrent glioblastoma treated with rhenium-186 labelled nanoliposomes [0.03%]
用铼-186标记的纳米脂质体治疗复发性脑胶质母细胞瘤的时空反应预测
Chase Christenson,Chengyue Wu,David A Hormuth nd et al.
Chase Christenson et al.
Rhenium-186 (186Re) labeled nanoliposome (RNL) therapy for recurrent glioblastoma patients has shown promise to improve outcomes by locally delivering radiation to affected areas. To optimize the delivery of RNL, we have developed a framewo...
A multiphysics model to predict periventricular white matter hyperintensity growth during healthy brain aging [0.03%]
健康大脑老化过程中预测脑室周围白质高信号变化的多物理模型
Andreia Caçoilo,Berkin Dortdivanlioglu,Henry Rusinek et al.
Andreia Caçoilo et al.
Periventricular white matter hyperintensities (WMH) are a common finding in medical images of the aging brain and are associated with white matter damage resulting from cerebral small vessel disease, white matter inflammation, and a degener...
Exploring the multiphysics of the brain during development, aging, and in neurological diseases [0.03%]
探究大脑在发育、衰老和神经疾病过程中的多物理属性
Johannes Weickenmeier
Johannes Weickenmeier
The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mec...
Integrating material properties from magnetic resonance elastography into subject-specific computational models for the human brain [0.03%]
基于磁共振弹性图的人体脑部个性化计算模型中的材料属性整合研究
Ahmed Alshareef,Andrew K Knutsen,Curtis L Johnson et al.
Ahmed Alshareef et al.
Advances in brain imaging and computational methods have facilitated the creation of subject-specific computational brain models that aid researchers in investigating brain trauma using simulated impacts. The emergence of magnetic resonance...
Bo Xue,Xuejun Wen,Ram Kuwar et al.
Bo Xue et al.
Recent efforts in biomaterial-assisted brain tissue engineering suggest that match of mechanical properties of biomaterials to those of native brain tissue may be crucial for brain regeneration. In particular, the mechanical properties of n...
Matthew Carter Childers,Michael Regnier,Mark Bothwell et al.
Matthew Carter Childers et al.
During protein synthesis, aminoacyl-tRNA synthetases covalently link amino acids with their cognate tRNAs. Amino acid mutations in glycyl-tRNA synthetase can disrupt protein synthesis and lead to a neurological disorder known as Charcot-Mar...