Active regulation of intrinsic curvature by eukaryotic phospholipid metabolism [0.03%]
由真核生物磷脂代谢主动调节的固有曲率
Daniel Milshteyn,Jacob R Winnikoff,Elida Kocharian et al.
Daniel Milshteyn et al.
Membranes contain thousands of different lipids, but it is poorly understood why their compositions vary across cell types and environments. We report that lipid metabolism balances the molecular curvature of phospholipids, a parameter that...
A critical review of microfluidic electroporation for therapeutic cell engineering [0.03%]
用于治疗性细胞工程的微流控电穿孔批判性评论
Madeline E Hoyle,Julio P Arroyo,Rafael V Davalos et al.
Madeline E Hoyle et al.
Microfluidic electroporation (MFEP) is emerging as a scalable, non-viral modality for engineering therapeutic cells. This review synthesizes recent progress in MFEP, outlining the key advantages of MFEP, including continuous processing at h...
Mechanistic insights into how water-network disorder determines the vitrification concentration in cryopreservation solutions [0.03%]
冷冻保存溶液中水网络无序度决定玻璃化浓度的机制见解
Euihyun Lee,Nora Gaby-Biegel,Rebecca D Sandlin et al.
Euihyun Lee et al.
Cryopreservation enables long-term storage of biological materials using cryoprotective agents (CPAs) to suppress ice crystal formation and prevent cell damage. However, despite considerable efforts, a molecular-level understanding of how C...
Bio-inspired biped microwalker with magneto-acoustic actuation for cell manipulation [0.03%]
一种用于细胞操作的仿生双足微 walker 磁声驱动器
Subrahmanyam Cherukumilli,David P Rivas,Fatma Ceren Kirmizitas et al.
Subrahmanyam Cherukumilli et al.
Bio-inspired and multi-modal microrobots have shown great potential in the field of biomedical and tissue engineering in recent years. Motivated by the efficiency and adaptability of nature, bio-inspired designs offer exciting possibilities...
Color-tunable luminescent TbxEuy(BDC) complexes assembled within liposome-based nanoreactors [0.03%]
一种基于脂质体的纳米反应器构建的发光铽铕混合物金属有机配合物及其可调谐光致发光性质研究
Aaron Torres-Huerta,Miriam de J Velásquez-Hernández,Sven Lempereur et al.
Aaron Torres-Huerta et al.
Precise stoichiometric control in multimetallic lanthanide nanosystems is essential for optical devices, sensing, and bioimaging applications owing to their composition-dependent emission properties. However, controlling metal composition, ...
3D environment favors persistent changes in cell functions and altered morphology, wrinkling, and biomechanical signature of the nucleus [0.03%]
三维培养环境引起细胞功能和核皱缩以及生物力学特征的持久变化
Raquel González-Novo,Héctor Zamora-Carreras,Marina Armesto et al.
Raquel González-Novo et al.
The interplay between cells and their surrounding microenvironment drives multiple cellular functions, including migration, proliferation, and cell fate transitions. The nucleus is a mechanosensitive organelle; however, the morphological an...
Biocompatibility of large-area two-dimensional electronic materials with neural stem cells [0.03%]
大面积二维电子材料与神经干细胞的生物相容性研究
R Taranath Jayanth,Rebecca Duquette,Shanmukh Kutagulla et al.
R Taranath Jayanth et al.
Two-dimensional (2D) electronic materials are emerging candidates for flexible neural interfaces, yet their biocompatibility remains unclear because most studies use exfoliated flakes or suspensions. Here, we report a systematic in vitro co...
A high-throughput biocatalytic platform for screening isomeric kainoid natural products [0.03%]
一种高通量生物催化平台 用于异构海人草素类天然产物筛选
Robert A Shepherd,Manasa Ramachandra,Austin R Hopiavuori et al.
Robert A Shepherd et al.
The growing field of biocatalysis relies on the generation of large, genetically diverse libraries for downstream colorimetric, fluorogenic, or chromatographic screening. However, challenges remain when assessing enzyme variants in a high-t...
Yuki Kagaya,Boyuan Liu,Daisuke Kihara
Yuki Kagaya
Determining the three-dimensional (3D) structure of RNA is crucial for understanding its diverse biological functions. The field of computational RNA structure prediction has recently been transformed by deep learning, which has dramaticall...
Nucleation dynamics in amyloid-beta dimerization revealed by single-molecule fingerprinting [0.03%]
单分子指纹识别揭示的淀粉样蛋白-β二聚化核动力学
A K M Kafi,Mathias Bogetoft Danielsen,Shixi Song et al.
A K M Kafi et al.
The aggregation of amyloid-beta ( A β ) peptides ( A β 1 - 40 or A β 1 - 42 ) is closely related to the pathology of Alzheimer's disease (AD). Soluble oligomers that appear during A β aggregation are primary neurotox...