Color-tunable luminescent TbxEuy(BDC) complexes assembled within liposome-based nanoreactors [0.03%]
一种基于脂质体的纳米反应器构建的发光铽铕混合物金属有机配合物及其可调谐光致发光性质研究
Aaron Torres-Huerta,Miriam de J Velásquez-Hernández,Sven Lempereur et al.
Aaron Torres-Huerta et al.
Precise stoichiometric control in multimetallic lanthanide nanosystems is essential for optical devices, sensing, and bioimaging applications owing to their composition-dependent emission properties. However, controlling metal composition, ...
3D environment favors persistent changes in cell functions and altered morphology, wrinkling, and biomechanical signature of the nucleus [0.03%]
三维培养环境引起细胞功能和核皱缩以及生物力学特征的持久变化
Raquel González-Novo,Héctor Zamora-Carreras,Marina Armesto et al.
Raquel González-Novo et al.
The interplay between cells and their surrounding microenvironment drives multiple cellular functions, including migration, proliferation, and cell fate transitions. The nucleus is a mechanosensitive organelle; however, the morphological an...
Biocompatibility of large-area two-dimensional electronic materials with neural stem cells [0.03%]
大面积二维电子材料与神经干细胞的生物相容性研究
R Taranath Jayanth,Rebecca Duquette,Shanmukh Kutagulla et al.
R Taranath Jayanth et al.
Two-dimensional (2D) electronic materials are emerging candidates for flexible neural interfaces, yet their biocompatibility remains unclear because most studies use exfoliated flakes or suspensions. Here, we report a systematic in vitro co...
A high-throughput biocatalytic platform for screening isomeric kainoid natural products [0.03%]
一种高通量生物催化平台 用于异构海人草素类天然产物筛选
Robert A Shepherd,Manasa Ramachandra,Austin R Hopiavuori et al.
Robert A Shepherd et al.
The growing field of biocatalysis relies on the generation of large, genetically diverse libraries for downstream colorimetric, fluorogenic, or chromatographic screening. However, challenges remain when assessing enzyme variants in a high-t...
Yuki Kagaya,Boyuan Liu,Daisuke Kihara
Yuki Kagaya
Determining the three-dimensional (3D) structure of RNA is crucial for understanding its diverse biological functions. The field of computational RNA structure prediction has recently been transformed by deep learning, which has dramaticall...
Nucleation dynamics in amyloid-beta dimerization revealed by single-molecule fingerprinting [0.03%]
单分子指纹识别揭示的淀粉样蛋白-β二聚化核动力学
A K M Kafi,Mathias Bogetoft Danielsen,Shixi Song et al.
A K M Kafi et al.
The aggregation of amyloid-beta ( A β ) peptides ( A β 1 - 40 or A β 1 - 42 ) is closely related to the pathology of Alzheimer's disease (AD). Soluble oligomers that appear during A β aggregation are primary neurotox...
A global thermodynamic-kinetic model capturing the hallmarks of liquid-liquid phase separation and amyloid aggregation [0.03%]
一种全球热力学-动力学模型 可捕获液-液相分离和淀粉样蛋白聚集的特征
Kamal Bhandari,Yunxiang Sun,Huayuan Tang et al.
Kamal Bhandari et al.
Amyloid aggregation is associated with numerous neurodegenerative, systemic, and metabolic diseases. Amyloidogenic proteins often undergo liquid-liquid phase separation (LLPS), but the effects of LLPS on amyloid aggregation remain unclear, ...
Angana De,Vikas Kumar,W Mark Saltzman et al.
Angana De et al.
Peptide nucleic acid (PNA) is a synthetic mimic of DNA where the deoxyribose-phosphodiester backbone is replaced with N-(2-aminoethyl) glycine units. The lack of deoxyribose-phosphodiester bonds enhances enzymatic stability and improves bin...
Reversal of the Leloir pathway to promote galactose and tagatose synthesis from glucose [0.03%]
莱洛途径逆向重编程促进葡萄糖转化生成半乳糖和塔格糖
Aaron M Love,Christopher G Toomey,Abhishek Kumar et al.
Aaron M Love et al.
D-Tagatose is a low-calorie rare sugar with health benefits as a low-glycemic sweetener. Current production methods are limited, often relying on galactose isomerization, and remain inefficient and costly. Here, we report a whole-cell proce...
A zirconium-89-labeled antibody-drug conjugate PET probe for noninvasive monitoring of Nectin4 expression in breast cancer and lung cancer [0.03%]
一种放射性金属89Zr标记的抗体药物偶联物正电子发射型计算机断层扫描探针非侵入式监测乳腺癌和肺癌中nectin4表达
Wenpeng Huang,Tianyao Wang,Yutong Liang et al.
Wenpeng Huang et al.
Triple-negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) are aggressive solid tumors with limited treatment options. Nectin cell adhesion molecule 4 (Nectin4) is a tumor-associated antigen frequently overexpressed in thes...