Upscaling of gaseous alkanes into large-volume commodity chemicals via photocatalytic acylation [0.03%]
通过光催化酰化技术将气态烷烃放大转化为大宗化学品
Akshay M Nair,Sergio Barbeira-Arán,Jose M Malga et al.
Akshay M Nair et al.
From a circular economy point of view, the valorization of gaseous alkanes into large-volume commodity chemicals is of the utmost importance. Such protocols would help reduce the current reliance on a petroleum-based economy and contribute ...
Erratum: Non-local Schrödinger diffusion model reveals mechanisms of critical brain dynamics [0.03%]
更正：非局部薛定谔扩散模型揭示了关键大脑动态的机制
Gustavo Deco,Yonatan Sanz Perl,Morten L Kringelbach
Gustavo Deco
[This corrects the article DOI: 10.1016/j.xcrp.2025.102663.]. © 2025 The Author(s).
Published Erratum
Cell reports. Physical science. 2025 Nov 19;6(11):102936. DOI:10.1016/j.xcrp.2025.102936 2025
Revealing the catalytic mechanism of the Fe(II)/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5 [0.03%]
揭示Fe(II)/α-酮戊二酸依赖的人类表观遗传修饰酶ALKBH5的催化机制
Fathima Hameed Cherilakkudy,Midhun George Thomas,Ann Varghese et al.
Fathima Hameed Cherilakkudy et al.
ALKBH5 is one of only two known human non-heme Fe(II)/2-oxoglutarate-dependent oxygenases that catalyze the demethylation of N6-methyladenine (m6A) in single-stranded mRNA, underscoring its role in diverse cancers. Unlike its homolog, the f...
Conformation-gated binding underlies kinetic asymmetry and negative cooperativity in ATP:cob(I)alamin adenosyltransferase [0.03%]
构象门控结合是ATP:维B12腺苷转移酶动力学不对称性和负协同性的基础
Guangjie Yan,Manhua Pan,Aaron M Keller et al.
Guangjie Yan et al.
Vitamin B12 (cobalamin) is a high-value yet scarce cofactor critical for metabolic homeostasis, necessitating efficient handling mechanisms. ATP:cob(I)alamin adenosyltransferase (MMAB) plays a central role in synthesizing, delivering, and r...
The dimerization domain of SARS-CoV-2 nucleocapsid protein is partially disordered and forms a dynamic high-affinity dimer [0.03%]
SARS-CoV-2核衣壳蛋白二聚化结构域部分无序并形成动态高亲和力二聚体
Jasmine Cubuk,J Jeremías Incicco,Kathleen B Hall et al.
Jasmine Cubuk et al.
The SARS-CoV-2 nucleocapsid (N) drives the compaction and packaging of the viral genome. Here, we focused on quantifying the mechanisms that control dimer formation utilizing single-molecule Förster resonance energy transfer to investigate...
Subhechchha Paul,Brinthan Kanesalingam,Yan Ma et al.
Subhechchha Paul et al.
About 1.9 gigatons of steel is produced every year, emitting 8% (3.6 gigatons) of global CO2 in the process. More than 50% of the CO2 emissions come from a single step of steel production, known as ironmaking. Hydrogen-based direct reductio...
Excitation and polarization of isolated neurons by high-frequency sine waves for temporal interference stimulation [0.03%]
用于时间干扰刺激的高频正弦波诱发和极化分离神经元
Iurii Semenov,Vitalii Kim,Giedre Silkuniene et al.
Iurii Semenov et al.
The capacity of temporal interference (TI) stimulation to target deep brain regions without affecting nearby surface electrodes remains uncertain. Using artifact-free optical recording, we compare excitation patterns and thresholds in hippo...
The Sabatier principle governs the performance of self-sufficient heterogeneous biocatalysts for redox biotransformations [0.03%]
Sabatier准则制约了异质生物催化剂的性能以实现红ox生物转化自给自足
Eleftheria Diamanti,Ainhoa Oliden-Sánchez,Daniel Grajales-Hernández et al.
Eleftheria Diamanti et al.
Self-sufficient heterogeneous biocatalysts (ssHBs), in which enzymes and cofactors are coimmobilized on the same support, provide in situ cofactor regeneration and reduce operating costs. However, the underlying mechanisms remain poorly und...
G-quadruplex and i-motif DNA structures form in the promoter of the key innate immune adaptor MYD88 [0.03%]
DNA G-四链体和i- motif结构形成于关键固有免疫接头分子MYD88的启动子区域中
Susie Brown,Kennith Swafford,Mason McCrury et al.
Susie Brown et al.
Innate immune responses rely on a critical adaptor protein, MYD88, to bridge extracellular inflammatory signals and transcription factor networks inside the cell. Dysregulation of MYD88 is associated with immunodeficiencies, autoimmunity, a...
Robustness in biomolecular simulations: Addressing challenges in data generation, analysis, and curation [0.03%]
生物分子模拟的稳健性：解决数据生成、分析和整理中的挑战
Anne M Brown,Justin A Lemkul
Anne M Brown
Computational simulations of biomolecules provide a wealth of information about the thermodynamic landscape of biologically important systems, kinetics of important cellular processes, and the biophysical basis of life. Despite the ubiquity...