Acute systemic endotoxin administration elevates neuroimmune markers and sickness behaviors in male and female Peromyscus californicus [0.03%]
急性全身内毒素给药可升高加州鼠雄性和雌性脑内的神经免疫标志物及疾病行为
Amy J Wegener,Hannah Stadtler,Hannah D Fulenwider et al.
Amy J Wegener et al.
The California mouse is a biparental monogamous rodent species used to study the neuroendocrine mechanisms underlying social stressors, but there is limited research investigating the neuroimmune response within the species to facilitate ou...
Altered gut microbial diversity, composition, and metabolomic potential in patients with major depressive disorder and recent suicide attempt [0.03%]
抑郁症伴近期自杀未遂患者的肠道微生物多样性、组成及代谢潜能改变
Emese Prandovszky,Hua Liu,Emily G Severance et al.
Emese Prandovszky et al.
This study investigates the role of the gut microbiome in suicidal behavior among individuals with major depressive disorder (MDD). Fecal samples from 50 hospitalized patients with MDD, including 35 with recent suicide attempts (60 % female...
Emerging role of complement system in the induction of neuroinflammation in adenylosuccinate lyase deficiency disorder [0.03%]
补体系统在腺苷磺酸裂解酶缺乏症诱导神经炎症中的作用不容忽视
Albert Frank Magnusen,Robert James Hopkin,Charles Vorhees et al.
Albert Frank Magnusen et al.
Adenylosuccinate lyase deficiency disorder (ADSLDD) is an ultra-rare autosomal recessive metabolic condition that leads to severe neurological impairment, with an estimated global prevalence of approximately 0.00125 cases per 100,000 indivi...
Eli Magen,Eugene Merzon,Shai Ashkenazi et al.
Eli Magen et al.
Background: Acute urticaria (AU) is characterized by the sudden onset of wheals, angioedema, or both, with symptoms resolving within 6 weeks. While the association between chronic urticaria and mental health disorders is ...
Biomarker-based profiling of fatigue in childhood cancer survivors: evidence for distinct inflammatory and glial-associated profiles [0.03%]
基于生物标志物的儿童癌症幸存者疲劳分类：炎症和胶质相关谱型的证据
Deveny Vanrusselt,Sabine Verschueren,Lize Van Meerbeeck et al.
Deveny Vanrusselt et al.
Background: Fatigue is a prevalent and burdensome late effect in childhood cancer survivors (CCS), yet its biological underpinnings remain poorly understood. This study examined associations between fatigue and blood-base...
C-reactive protein is associated with pain-type somatic symptoms independent of mental health symptoms in adolescents: Evidence from the ALSPAC study [0.03%]
C-反应蛋白与青少年疼痛性躯体症状独立于心理健康症状相关：来源于ALSPAC研究的证据
J Cooney-Quane,D S Thomas,Y M Nolan et al.
J Cooney-Quane et al.
Depression and anxiety disorders frequently first present during adolescence, and both conditions are often comorbid with the experience of pain-type somatic symptoms. Moreover, increased concentrations of blood-derived inflammatory markers...
Characterization of inflammatory and neurofunctional markers in the context of early life stress among a clinical sample of people maintained on buprenorphine for opioid use disorder [0.03%]
在临床使用丁丙诺啡治疗阿片类药物使用障碍的人群中，早期生活应激背景下炎症和神经功能标志物的特征研究
Madison M Marcus,Tiffany Pignatello,Paul Howell et al.
Madison M Marcus et al.
Early life stress (ELS) is associated with an increase in expression of inflammatory cytokines and opioid addiction-related behaviors. Maintenance on medication for opioid use disorder (OUD) can opposingly affect these endpoints. The study ...
Impact of sanitary conditions and dietary amino acids on behaviour and brain monoamine levels in piglets [0.03%]
卫生条件和饮食氨基酸对仔猪行为及脑单胺水平的影响
Ilaria Minussi,Walter J J Gerrits,Alfons J M Jansman et al.
Ilaria Minussi et al.
Background: Immune activation due to poor hygienic conditions may affect behaviour, as the immune system and brain are linked through several mechanisms. This putative effect may partly result from increased amino acid (A...
Maternal immune activation alters infant attentional processing in a nonhuman primate model [0.03%]
母体免疫激活会改变非人灵长类动物后代的注意加工能力
J A Hubbard,S Chen,A M Iosif et al.
J A Hubbard et al.
Maternal infection during pregnancy has been linked to the emergence of neurodevelopmental disorders. Preclinical animal models of maternal immune activation (MIA) have provided critical mechanistic links between maternal cytokines and alte...
Brain nitric oxide and inflammation in chronic intermittent hypoxia: Contributors to cognitive impairment and hypertension [0.03%]
慢性间歇性缺氧引起的脑内一氧化氮和炎症反应与认知功能障碍及高血压的关系研究
Cephas B Appiah,Ato O Aikins,George E Farmer et al.
Cephas B Appiah et al.
Chronic intermittent hypoxia (CIH) is a key feature of obstructive sleep apnea (OSA) and leads to physiological changes that can cause cardiovascular and neurological issues. This review explores the role of nitric oxide (NO) and inflammati...