Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep [0.03%]
昼夜型预测流感疫苗的反应以及与疫苗接种前后的睡眠差异相关
Elizabeth M Harrison,Rachel U Lee,Chad K Porter et al.
Elizabeth M Harrison et al.
Identifying strategies to enhance vaccine response supports public health efforts, particularly in settings where individuals face elevated exposure risks, such as during military deployment or in other high-demand contexts. Accumulating ev...
Theiler's murine encephalomyelitis virus as the infectious agent for a virally induced mouse model of Parkinson's disease [0.03%]
提拉病毒作为帕金森病的致病病毒和致病机理研究
Tae Wook Kang,Rahul Srinivasan,Candice Brinkmeyer-Langford et al.
Tae Wook Kang et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder with a prevalence of over ten million patients worldwide. The etiology of PD remains unclear but neuroinflammation specifically associated with viral infection ha...
Discrepancies in loneliness and social isolation predict cognitive impairment through chronic disease burden [0.03%]
孤独和社会隔离的差异通过慢性疾病负担预测认知障碍
Dakota W Cintron,Tomiko Yoneda,Hebi Wang et al.
Dakota W Cintron et al.
Background: The discrepancy between loneliness and objective social isolation (social asymmetry) has been linked to poorer cognitive aging, yet the biobehavioral pathways underlying this association remain unclear. This s...
Multi-omic analysis reveals brain-blood concordance and persistent neuroimmune reprogramming with stress and toxicant exposure in a mouse model of Gulf War Illness [0.03%]
多组学分析揭示了脑部和血液的一致性以及压力和毒物暴露小鼠模型的慢性疲劳综合征的神经免疫重编编程的一致性及持久性
A Sasaki,K A Kelly,L T Michalovicz et al.
A Sasaki et al.
Gulf War Illness (GWI) is a chronic neuroimmune condition affecting veterans of the 1990-91 Gulf War. Current treatments primarily target symptom relief, and the biological mechanisms underlying GWI remain poorly understood. Using a validat...
Shared functional microbiome signatures in Parkinson's disease and constipation predominate irritable bowel syndrome despite taxonomic divergence [0.03%]
帕金森病和便秘的功能性微生物组特征与分类学分歧无关但优先于肠易激综合征
Emily C Hoedt,Grace L Burns,Kateleen E Hedley et al.
Emily C Hoedt et al.
Background: Gastrointestinal dysfunction, including constipation, is a common non-motor feature of Parkinson's disease (PD) and often precedes motor symptoms. The gut microbiome interacts with the host through neural, hor...
Distinct serum and cerebrospinal fluid metabolic signatures associate with pain and fatigue in knee osteoarthritis [0.03%]
膝骨关节炎血清和脑脊液代谢标志物与疼痛和疲劳的关系研究
Aline U Bjerkhaug,Jenny E Jakobsson,Aisha S Ahmed et al.
Aline U Bjerkhaug et al.
Pain is the primary reason patients with knee osteoarthritis (OA) seek surgical intervention when pharmacological treatments lose efficacy. The pain arises from complex mechanisms involving peripheral and central sensitization and inflammat...
Inflammation, mental health, and alcohol behaviors: Testing links leveraging a familial community sample [0.03%]
炎症，心理健康和饮酒行为：利用家庭社区样本进行检验连接性研究
Ryan Bruellman,Chandra A Reynolds,Andrew Smolen et al.
Ryan Bruellman et al.
Evidence that inflammation is related to poorer mental health largely comes from clinical samples. This pre-registered study examined whether these findings extend to depression, alcohol use, and alcohol use disorder (AUD) in a large sample...
Kynurenine pathway metabolites are increased in inflammatory depression and decrease with omega-3 treatment [0.03%]
炎症性抑郁患者血清犬尿氨酸代谢物水平升高的临床研究及ω-3脂肪酸的治疗作用
Jesper Lindahl,Gustav Söderberg Veibäck,Klara Suneson et al.
Jesper Lindahl et al.
Activation of the kynurenine pathway (KP) with resulting accumulation of neuroactive metabolites may be a downstream pathophysiological mechanism of inflammatory depression. The aims of this study were to investigate KP metabolites in infla...
Metabolomic levels mediate the link between socioeconomic factors and changes in declarative memory in women with and without HIV [0.03%]
代谢水平介导了社会经济因素与女性（艾滋病患者或非艾滋病患者）陈述性记忆变化之间的联系
César Higgins Tejera,Raha Dastgheyb,Eran F Shorer et al.
César Higgins Tejera et al.
Introduction: Understanding metabolic pathways linking socioeconomic conditions and declarative memory (DM) may reveal interventional targets. Methods: ...
Validation of the Wood Mental Fatigue Inventory in adolescents with myalgic encephalomyelitis/chronic fatigue syndrome [0.03%]
青少年肌痛性脑脊髓炎/慢性疲劳综合症患者中Wood精神疲劳量表的有效性验证
David C Welch,Charles C Edwards,Camille A Broussard et al.
David C Welch et al.
Background: There is no consensus regarding the most reliable and valid measures of cognitive dysfunction in adolescents and adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The Wood Mental Fatigue...