Both donor and recipient sex determine behavioral and neuroimmune outcomes in a gut microbiota transfer experiment from the unpredictable chronic mild stress model of depression [0.03%]
供体和受体的性别决定不确定慢性轻度压力模型中抑郁症的肠道微生物群移植实验的行为和神经免疫结果
Meagan E Hinks,Alexandre S Maekawa,Mark D Corrigan et al.
Meagan E Hinks et al.
Sex differences in major depressive disorder (MDD) are well established, yet the conditions under which immune dysfunction contributes to depression-and how this differs by sex-remain poorly defined. The gut-brain axis represents a key immu...
White matter microstructural abnormalities in neurological poste-acute sequelae of coronavirus disease: Imaging signatures consistent with persistent neuroinflammation [0.03%]
新型冠状病毒疾病的神经急性期后遗症的白质微结构异常：持续性神经炎症的一致影像学特征
Chuan Huang,Xinlan Zhang,Jia Ying et al.
Chuan Huang et al.
Background: Essential workers, many of whom were infected with coronavirus disease (COVID-19) at work before vaccination, developed Neurological Post-Acute Sequelae of COVID-19 (N-PASC) at high rates. ...
Neural response to reward as a potential pathway from inflammation to anhedonia in adolescents at risk for depression [0.03%]
炎症通过奖赏反应导致抑郁症高危青少年情绪快感缺失的可能机制研究
Melissa M Nance,Tina Gupta,Morgan Lindenmuth et al.
Melissa M Nance et al.
Depression in adolescents has been associated with high levels of circulating inflammatory markers, with a putative mechanism including disrupted function in neural reward circuitry leading to anhedonia, a symptom that involves difficulty w...
Mania and psychosis following chimeric antigen receptor T-cell therapy: A report of two cases and mechanistic discussion [0.03%]
嵌合抗原受体T细胞治疗后出现躁狂发作和精神障碍2例及发病机制讨论
Todd M Stollenwerk,Morgan E Barnett,Angela S Steineck et al.
Todd M Stollenwerk et al.
CD20. CD19-targeted chimeric antigen receptor modified T-cell immunotherapy (CAR T-cell therapy) is an experimental CAR with increasing use for the treatment of lymphoid malignancies. Although acute neuropsychiatric toxicities are well desc...
Lindsay S McAlpine,Eran F Shorer,Jennifer Chiarella et al.
Lindsay S McAlpine et al.
The role of vascular inflammation in neuropsychiatric Long COVID (LC) is suspected but not well understood. This study evaluated whether vascular inflammation is present in individuals with neuropsychiatric LC and how it relates to cognitiv...
Comprehensive analysis of cytokines in depression: independent data from patient plasma and post-mortem ventromedial prefrontal cortex [0.03%]
抑郁症细胞因子的全面分析：来自患者血浆和死后腹内侧前额叶皮质的独立数据
Reza Rahimian,Jonas Hagenberg,Claudia Belliveau et al.
Reza Rahimian et al.
Preclinical and clinical evidence has implicated inflammation in the pathophysiology of depression. Abnormal cytokine levels in blood, cerebrospinal fluid, and post-mortem brain samples have been associated with depression. To our knowledge...
Psychological stress during medical internship is associated with inflammatory signatures linked to mental health [0.03%]
心理压力与医学实习期间的炎症标志物有关联
Jasmin Ewert,Laura Meine,Ella McPherson et al.
Jasmin Ewert et al.
Psychosocial stress is a major risk factor for mental disorders and affects peripheral physiology, including immune function. However, it remains unclear how stress exposure in otherwise healthy individuals alters circulating immune markers...
A neuroimmune framework for understanding adolescent stress and risk of alcohol misuse [0.03%]
神经免疫框架在青少年压力与酒精滥用风险方面的应用理解
Léa Aeschlimann,Narimane Bouzourène,Clara Rossetti et al.
Léa Aeschlimann et al.
Alcohol use disorder (AUD) represents a critical public health challenge, with early-life adversity conferring heightened risk for compulsive drinking patterns. Alcohol has long been known to exert direct effects on developing neurotransmit...
Immune fitness and biomarkers of immune function: Relationships with the oral and gut microbiome composition [0.03%]
免疫功能和生物标志物与口腔及肠道菌群组成的关系
Guusje A Ulijn,Emina Išerić,Aurora J A E van de Loo et al.
Guusje A Ulijn et al.
Background: Immune fitness refers to the body's capacity to respond to health challenges, such as infections, by activating an appropriate immune response. The aim of the current study was to investigate the relationship ...
Oral microbiome dysbiosis mediates the link between emotional disorders and systemic inflammation in heart failure [0.03%]
情绪障碍与心脏衰竭系统性炎症的联系或由口腔菌群失调介导
Qingyang Wu,Ziqing Yu,Jinya Cao et al.
Qingyang Wu et al.
Emotional disorders (EDs) are prevalent in heart failure (HF) and predict poor outcomes, yet their interplay with oral health and systemic inflammation remains unclear. This integrated cross-sectional analysis of NHANES data and a prospecti...