Integrative evidence for causal links between gut microbiota and Schizophrenia: A Mendelian randomization and 16S rRNA study [0.03%]
整合证据证明肠道微生物群与精神分裂症之间的因果关系：基于孟德尔随机化和16S rRNA的研究
Jianye Zeng,Xiumei Zhu,Huajie Ba et al.
Jianye Zeng et al.
Background: Schizophrenia is a severe psychiatric disorder with a complex etiology. Emerging evidence implicates the gut microbiota in its pathogenesis via the microbiota-gut-brain axis, although causal relationships rema...
Interleukin-6 moderates the relationship between social support, strain, and future depressive symptoms [0.03%]
白细胞介素-6在社会支持、应激和未来抑郁症状之间的关系中起调节作用
Timothy Bang Hao Aw,Nur Hani Zainal
Timothy Bang Hao Aw
Background: Inflammation has been increasingly implicated in major depressive disorder (MDD), with interleukin-6 (IL-6) emerging as a key biomarker. How this relates to psychosocial risk factors, such as social support an...
Altered immune and inflammatory gene expression in prefrontal cortex of antipsychotic-free schizophrenia subjects [0.03%]
抗精神病药物阴性精神分裂症患者前额叶皮层中免疫和炎症基因表达的改变
Sergi Mas,Xabier Elcoroaristizabal-Martín,Carlos Cortijo Bringas et al.
Sergi Mas et al.
Gene expression studies in dorsolateral prefrontal cortex (DLPFC) of subjects with schizophrenia have repeatedly reported alterations in immune and inflammatory responses as well as neuronal and mitochondrial processes. Whether the findings...
Blood diagnostic biomarkers for neurologic manifestations of long COVID [0.03%]
用于长期新冠神经症状的血液诊断生物标志物
A S Padhye,I J Koralnik,B A Hanson et al.
A S Padhye et al.
Background: SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, millions of deaths and ongoing manifestations post COVID-19. "Long Covid", a Post-Acute Sequelae of COVID-19 (PASC), i...
Combined effects of calorie restriction and chronic stress on systemic inflammation and gut microbiota in rats exposed to Leptospira interrogans lipopolysaccharide [0.03%]
卡路里限制与慢性应激联合处理对钩端螺旋体脂多糖诱导的大鼠系统性炎症及肠道菌群的影响
Pavlo Petakh,Yaroslav Stravskyy,Iryna Halabitska et al.
Pavlo Petakh et al.
Background: Calorie restriction (CR) is widely studied for its anti-inflammatory and immunomodulatory effects. However, under conditions of chronic stress-such as those experienced during war, displacement, or famine-its ...
Acute and chronic nasal inflammation induces lymphangiogenesis in the olfactory mucosa in mice [0.03%]
急性鼻炎和慢性鼻炎可诱导小鼠嗅粘膜淋巴管生成
Suzuho Komaki,Ryuichi Imai,Yuzuki Sugimoto et al.
Suzuho Komaki et al.
Background: Lymphangiogenesis, the formation of new lymphatic vessels, is primarily driven by VEGF-C-mediated activation of VEGFR-3 and plays a critical role in immune regulation and tissue repair. Although lymphangiogene...
Assessing the neuroendocrine and psychological effects of acute everolimus administration in healthy male participants [0.03%]
评估依维莫司在健康男性受试者中的神经内分泌和心理效应
Lucie Jacquet,Anna Lena Friedel,Elisa Orth et al.
Lucie Jacquet et al.
Previous experimental studies have shown that immunosuppressive mechanistic target of rapamycin inhibitors can induce neuropsychological changes, such as anxiety and depression, in healthy rodents. Furthermore, psychiatric conditions includ...
Astroglia-mediated neuroinflammation as a putative mechanism of neurological outcomes in COVID-19? Insights from a Brazilian cohort [0.03%]
巴西一项关于新冠患者的队列研究：胶质细胞介导的神经炎症可能是新冠肺炎所致神经后遗症的作用机制？
Ethiane Segabinazi,Fernando R Tocantins,Talita Glaser et al.
Ethiane Segabinazi et al.
NeuroCOVID-19 has emerged as a significant global health concern, presenting a wide spectrum of neurological manifestations, including headaches, brain fog and anosmia. While mounting evidence indicates that SARS-CoV-2 infection compromises...
Break free from cognitive impairment: The magic of exercise-induced molecules [0.03%]
突破认知障碍：运动诱导分子的魔力
Wenbo Liu,Hui Zhang,Qiuting Zeng et al.
Wenbo Liu et al.
•Exercise-induced molecules regulate cognition via trophic, immune, and metabolic pathways.•Muscle-brain crosstalk contributes to cognitive resilience in aging and neurodegeneration.•CTSB, lactate and others show dual roles-protective ye...
Alterations in functional connectivity analyzed using MREG in patients with suspected autoimmune psychosis spectrum syndromes [0.03%]
疑似自身免疫精神病谱系综合征患者的MREG功能连接改变分析
Katharina von Zedtwitz,Ludger Tebartz van Elst,Isabelle Matteit et al.
Katharina von Zedtwitz et al.
Introduction: In NMDA-R encephalitis, which is typically accompanied by psychotic symptoms, conventional magnetic resonance imaging (MRI) is often normal, despite widespread alterations in functional connectivity. This is...