Severity of SARS-CoV-2 infection increases the risk of generalized anxiety disorder, major depressive disorder, and post-traumatic stress disorder in COVID-19 survivors: a prospective longitudinal cohort study [0.03%]
SARS-CoV-2感染的严重程度会增加COVID-19幸存者患广泛性焦虑障碍、重度抑郁障碍和创伤后应激障碍的风险：一项前瞻性纵向队列研究
Hernan F Guillen-Burgos,Sergio Moreno-López,Juan F Gálvez-Flórez et al.
Hernan F Guillen-Burgos et al.
Background: The COVID-19 pandemic has significantly impacted global mental health. However, individuals with confirmed SARS-CoV-2 infection, diagnosed either clinically or through serological testing, appear to be at high...
Chronotherapeutic administration of neoadjuvant chemotherapy reduces cancer-related fatigue-like behavior [0.03%]
按时化疗可减少新辅助化疗引起的类癌疲劳行为
Claire O Kisamore,Caleb A Kisamore,Jayla M Boyd et al.
Claire O Kisamore et al.
Circadian rhythms are ∼24-h oscillations in physiology and behavior and can be used to optimally time treatment, a practice known as chronotherapy. Chronotherapy for cancer treatment was first successfully utilized >50 years ago and has be...
From weather to symptoms: Preliminary links between weather and inflammation in schizophrenia [0.03%]
从天气到症状：关于精神分裂症的初步研究揭示了天气与炎症之间的联系
Stefan Modzelewski,Maria Suprunowicz,Aleksandra Julia Oracz et al.
Stefan Modzelewski et al.
Background: Negative symptoms in schizophrenia are a major determinant of long-term disability, yet drivers of symptom variability remain poorly understood. Weather-related immune shifts have been proposed as a potential ...
Associations among discrimination, genetic susceptibility to inflammation, and C-reactive protein [0.03%]
歧视、炎症的遗传易感性和C反应蛋白之间的关系
Alisha A Crump,Jemar R Bather,Robert F Krueger et al.
Alisha A Crump et al.
Genetic liability to inflammation may lead to heightened perception of discrimination (gene-environment correlation) or interact with discrimination exposure to amplify inflammation risk (gene-environment interaction). The present study exa...
Inflammatory reprogramming of immature oligodendrocytes perturbs myelination and neurodevelopment in a dual-hit model of preterm brain injury [0.03%]
免疫系统重新编程未成熟的少突胶质细胞会破坏双损伤模型中的髓鞘形成和神经发育
Xueling Ma,Wen Jia,Xingdao Zhang et al.
Xueling Ma et al.
Background: Preterm infants are highly susceptible to white matter injury, in part due to exposure to perinatal inflammation and/or hypoxia. These insults disrupt oligodendrocyte (OL) lineage maturation, leading to impair...
Microglia depletion alleviates the disruptions in circadian rhythms and anxiety caused by bmal1 deficiency [0.03%]
Bmal1缺陷引起的生物钟节律紊乱和焦虑行为通过微胶质细胞清除得到缓解
Song Gong,Yuxue Chen,Lihan Su et al.
Song Gong et al.
Microglia, the intrinsic immune cells of the brain, play a crucial role in maintaining neuronal health and circadian rhythms. BMAL1 is a core transcriptional regulator of the molecular circadian clock that coordinates daily rhythms in physi...
Increased circulating TREM2+ microglial extracellular vesicles in aged APP/PS1 Alzheimer's disease rats [0.03%]
APP/PS1老年型阿尔茨海默病大鼠血循环中携带TREM2+的小胶质细胞外泌体增多
Sarah J Myers,Manoj Reddy Medapati,Brian L Allman et al.
Sarah J Myers et al.
TREM2 is a microglial marker important in Alzheimer's disease (AD) risk and pathogenesis, but current methods to detect microglial TREM2 expression in vivo are limited. Circulating extracellular vesicles (EVs) show promise as potential biom...
Vagal neuropathies: An underrecognized potential driver of physical, mental, and immune symptoms [0.03%]
迷走神经病变：一个未被充分认识的躯体症状、精神症状和免疫系统症状潜在驱动因素
Bandy Chen,Laurent Gautron
Bandy Chen
Peripheral neuropathies are widely recognized disorders of the peripheral nervous system. However, research and clinical attention have focused predominantly on somatosensory, somatic motor, and sympathetic neurons, with comparatively littl...
Reduced serum interleukin-2 associates with higher motor severity and along with CD4 T cell alterations may be an early event in isolated REM Sleep Behaviour Disorder [0.03%]
血清白介素-2降低与较高的运动严重性相关，并且与CD4 T细胞改变联合可能在孤立的快速眼动睡眠行为障碍中是一个早期事件
Fatima Afaar,Priscilla Youssef,Laura Hughes et al.
Fatima Afaar et al.
Background: Emerging evidence indicates that peripheral immune changes occur in patients with isolated REM sleep behaviour disorder (iRBD) and may contribute to the conversion of this dream enactment disorder to a neurode...
Adverse childhood experiences (ACEs) moderate the association between traffic exposure and circulating inflammatory biomarkers [0.03%]
童年不良经历（ACE）调节交通暴露与循环炎症生物标志物之间的关系
Hector A Olvera-Alvarez,Jose Guillermo Cedeño-Laurent,Aaron M Eisen et al.
Hector A Olvera-Alvarez et al.
Although traffic-related air pollution and early-life adversity have both been related to increased inflammatory activity and cardiovascular disease, rarely have these two risk factors been examined together. To address this issue, we inves...