Polina Stepanova,Merja H Voutilainen,Ove Eriksson et al.
Polina Stepanova et al.
Modelling of human neurological diseases uses a plethora of ever-more sophisticated methods and approaches. For Huntington's disease (HD), which affects specific neuronal types and circuits in the brain, this has meant the use of both neuro...
Leveraging microbiota-metabolites to reduce inflammation and promote functional recovery following spinal cord injury in female mice [0.03%]
利用微生物群代谢物减轻炎症并促进脊髓损伤后雌性小鼠的功能恢复
Ashley J Douthitt,Aaron Bennett,Alexandra Koustova et al.
Ashley J Douthitt et al.
Spinal cord injury induces extensive neurological impairment and drives systemic and tissue-level inflammatory responses that accelerate secondary systemic damage. Emerging evidence suggests that gut microbiota-derived metabolites can influ...
Immune and metabolic disturbance as a function of genetic risk and phase of illness in major depression [0.03%]
遗传风险和疾病阶段对重大抑郁障碍患者免疫及代谢紊乱的影响
David M Howard,Lachlan Gilchrist,Petroula Proitsi et al.
David M Howard et al.
Immune and metabolic factors are important in the pathophysiology of major depressive disorder (MDD) but we know little about how these factors manifest in relation to the status of depressive illness-from genetic risk for MDD, to a depress...
Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study [0.03%]
长期新冠和康复期新冠患者的脑组织微结构和神经化学谱系改变：多模式磁共振成像研究
Kiran Thapaliya,Sonya Marshall-Gradisnik,Maira Inderyas et al.
Kiran Thapaliya et al.
Background: Diverse neurological symptoms are experienced by long COVID and COVID-19 recovered individuals. However, the long-term effects of SARS-CoV-2 in the brain of both groups are underexplored. This study aimed to i...
Coordination of inflammatory and adrenocortical stress response during pregnancy and variation by mental health [0.03%]
孕期炎症和肾上腺应激反应的协调以及因心理健康状况的不同而产生的差异
Heidemarie K Laurent,Sherryl H Goodman,Douglas A Granger et al.
Heidemarie K Laurent et al.
Well-regulated coordination of a multi-system stress response is particularly consequential for intergenerational health during pregnancy, when maternal stress systems typically adapt to protect the fetus. However, little is known about pat...
Effects of palmitoylethanolamide in clinical high-risk for psychosis: A nonrandomized open-label trial [0.03%]
棕榈乙醇胺在临床精神病高危人群中的疗效：一项非随机开放标记试验
Riccardo Bortoletto,Marco Garzitto,Marta Basaldella et al.
Riccardo Bortoletto et al.
Clinical high-risk (CHR) for psychosis state still lacks effective and safe treatments. Recent evidence supports the anti-neuroinflammatory properties of fatty acid palmitoylethanolamide (PEA) dietary supplementation across the psychosis sp...
Moderating effects of individual factors on the relationship between inflammation and psychophysiological states in healthy adults [0.03%]
健康成年人中个体因素对炎症和心理生理状态之间关系调节作用的影响研究
Kao Yamaoka,Yuri Ishii,Yuri Terasawa
Kao Yamaoka
Systemic inflammation affects psychological processes. Although the association between inflammation and psychophysiological state has been extensively investigated in patients with depression or inflammatory disease, how this relationship ...
IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications [0.03%]
IL-1β和TNF-α所致的睡眠改变：神经免疫机制及行为影响
Nathan Zhang,Kyungsoo Park,Shinjae Chung et al.
Nathan Zhang et al.
Sleep is a fundamental physiological state essential for immune function, metabolic regulation, and recovery from illness. During infection, sleep patterns are altered in a stereotyped fashion-characterized by increased non-rapid eye moveme...
Social stress changes gut microbiome composition in male, female, and aggressor mice [0.03%]
社交压力会改变雄性、雌性和“施暴者”小鼠的肠道菌群组成
Isabel Garcia,Fatmanur Kilic,Chris-Ann Bryan et al.
Isabel Garcia et al.
Psychological stress causes gut dysbiosis, which is associated with adverse effects on physical and mental health in humans and mice. Identifying taxa of gut bacteria changed by stress, and whether stress differentially alters their relativ...
Relationship between body mass index, gray matter volume and peripheral inflammation in patients with post-COVID condition [0.03%]
BMI、灰质体积与新冠后症状患者的外周炎症之间的关系
Luise Victoria Claaß,Franziska Schick,Tonia Rocktäschel et al.
Luise Victoria Claaß et al.
Background: Obesity, a condition associated with low-grade peripheral inflammation, is an independent risk factor for severe COVID-19 and has been linked to structural brain alterations. Given that post-COVID condition (P...