Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner [0.03%]
青春期的社会孤立以性别特异性的方式改变新颖物体识别记忆、脑和肠道基因表达及微生物组构成
Raise Ahmad,Gosia Zobel,Rina Hannaford et al.
Raise Ahmad et al.
Adolescent social isolation is a known risk factor for anxiety and depression related disorders, yet its effects on brain-gut communication and potential sex differences remain unclear. We hypothesised that isolation would heighten anxiety-...
Subjective and objective working memory deficits in the post-acute phase of COVID-19 in a clinical trial population [0.03%]
新冠患者工作记忆的主观和客观缺损：一项临床试验结果
Sofie Buer,Bjørn I Hagen,Arne Søraas et al.
Sofie Buer et al.
Importance: Cognitive difficulties are commonly reported following COVID-19, yet the relationship between subjective and objective working memory (WM) deficits remains unclear. Examining both types of measures may improve...
State educational contexts in childhood and systemic inflammation in later life: Evidence from the health and retirement study [0.03%]
童年时期的国家教育背景与晚年时期机体的系统性炎症反应之间的关系——来自健康与退休调查的证据
Mateo P Farina,Heide Jackson,Jennifer A Ailshire et al.
Mateo P Farina et al.
Chronic, low-grade inflammation is a key biological mechanism linking early-life adversity to morbidity and disability in later adulthood. Although educational attainment has been consistently associated with lower inflammation, the role of...
Investigation of BOLD signal intensities in long COVID patients using 7T functional MRI [0.03%]
利用7T功能性磁共振成像研究长期COVID患者的BOLD信号强度
Maira Inderyas,Kiran Thapaliya,Sonya Marshall-Gradisnik et al.
Maira Inderyas et al.
Long COVID is increasingly associated with disruption in brain homeostasis, manifesting as severe neurological dysfunction, brain fog and cognitive impairment. This present study investigated localised cognitive deficits in long COVID patie...
Lipopolysaccharide-induced systemic inflammation alters courtship ultrasonic vocalizations in male mice [0.03%]
脂多糖诱导的小鼠全身炎症会改变雄性小鼠的求偶超声信号
Mizuki Yamamoto,Haruki Kasahara,Kazuko Hayashi et al.
Mizuki Yamamoto et al.
Background: Sickness behavior comprises a coordinated constellation of motivational, cognitive, and social alterations that emerge during systemic inflammation. Although reductions in locomotion, feeding, and social engag...
Celecoxib adjunct to antidepressants for major depressive disorder: Systematic review and meta-analysis [0.03%]
环氧化酶-2抑制剂作为抗抑郁药增效治疗重度抑郁症的疗效及安全性系统综述和meta分析
Manit Srisurapanont,Chawisa Suradom,Sirijit Suttajit
Manit Srisurapanont
This systematic review and meta-analysis of randomized, placebo-controlled trials evaluated the efficacy, acceptability, and tolerability of celecoxib as an adjunct to antidepressants for major depressive disorder (MDD). PubMed, Embase, the...
Prenatal cigarette exposure induces offspring hyperactivity and affective alterations via gut -brain axis metabolic dysregulation and region-specific neuronal hyperactivation [0.03%]
产前接触香烟通过代谢失调和区域特异性神经元过度活化诱导后代多动和情绪改变
Tian-Lei Zhang,Wen Qiu,Xin-Yu Shi et al.
Tian-Lei Zhang et al.
Prenatal cigarette exposure (PCE) is a major preventable risk factor for neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD), but the underlying mechanisms extending beyond direct developmental neurotoxicity...
Inflammation, fronto-amygdala connectivity, and negative affective reactivity to daily stress in adolescents [0.03%]
青少年日常压力下的炎症、前额叶杏仁核连接和负面情绪反应
Eugenia Giampetruzzi,Justin P Yuan,Jessica P Uy et al.
Eugenia Giampetruzzi et al.
Background: Maladaptive affective responses to daily stress in adolescence are a robust risk factor for the development of psychopathology. Importantly, however, adolescents vary widely in the magnitude of their affective...
Sex differences in the associations between lifestyle, intestinal permeability and brain health in middle-aged adults [0.03%]
生活方式与肠道通透性对中年人脑健康影响的性别差异研究
R Tume,G Cattaneo,F Carmona-Pontaque et al.
R Tume et al.
Background: Evidence suggests that brain health is related to intestinal health. Increased intestinal permeability (IP) biomarkers as risk factors for reduced brain health, considering sex differences in the gut-brain axi...
Th1/Th17-linked transcription factors TBX21 and RORC were associated with clinical response to rituximab in treatment-resistant schizophrenia [0.03%]
与难治性精神分裂症治疗反应相关的TH1/TH17相关转录因子TBX21和RORC
Simon Bylund,Daniel Eklund,Mats B Humble et al.
Simon Bylund et al.
Background: One third of patients with schizophrenia do not achieve remission with current antipsychotic treatments. Converging data support an immune-mediated component in a subset of cases, overlapping with autoimmune C...