Body talk: Correlates of gut-immune dysregulation phenotypes in people living with HIV who use methamphetamine [0.03%]
HIV阳性人群使用冰毒与肠道免疫失调表型及其相关因素研究
Wilson Vincent,Annesa Flentje,Benjamin S Dominguez et al.
Wilson Vincent et al.
Background: Microbial translocation, immune activation, inflammation, and dysregulated metabolism of neurotransmitter precursors are interacting pathophysiologic processes linked to neuropsychiatric comorbidities and fast...
PPARγ as a predictive biomarker for antidepressant response in major depressive disorder: Insights from TNIP1 transcriptional regulation [0.03%]
核受体γ作为预测重大抑郁症抗抑郁药反应的生物标志物：来自TNIP1转录调控的启示
Yu-Wei Lin,Daw-Yang Hwang,Yi-Yung Hung
Yu-Wei Lin
Introduction: Major depressive disorder (MDD) is a debilitating disease possibly linked to immune defense mechanisms. TNIP1, a key anti-inflammatory regulator in NF-κB and TLR pathways, is implicated in MDD, but its tran...
Accelerated Theta Burst Stimulation Transcranial Magnetic Stimulation (iTBS-TMS) Pururauka program for severe depressive episode and suicide ideation [0.03%]
改良经颅磁刺激(theta burst stimulation，TBS-TMS)治疗重度抑郁发作及自杀观念的临床研究
Hesed Virto-Farfan,Carlos Virto,Gustavo E Tafet
Hesed Virto-Farfan
Introduction: The Pururauka protocol is an accelerated intermittent theta burst stimulation (iTBS) paradigm designed to rapidly reduce depressive symptoms and suicidal ideation in individuals with severe major depressive ...
E.coli-derived CsgA-peptides stimulate cytokine production in microglia and lead to transient changes in neocortical Aβ-levels in pre-plaque APP SWE /PS1 ΔE9 and wild type mice [0.03%]
由大肠杆菌衍生的CsgA肽刺激小胶质细胞产生细胞因子并导致预斑块APP SWE / PS1ΔE9和野生型小鼠neo皮层Aβ水平发生变化
Leda Mygind,Gabriel Jensen,Victoria Neesgaard et al.
Leda Mygind et al.
Epidemiological and pre-clinical data propose that infections can accelerate the cognitive decline in Alzheimer's disease (AD) and other dementias. The implication of infectious agents, and especially the role of E.coli and other amyloid-pe...
Gut microbiota-neuroinflammation axis: A new mechanism and therapeutic target for comorbid depression in epilepsy [0.03%]
肠道微生物群-神经炎症轴：癫痫共病抑郁的新机制和治疗靶点
Xiujuan Wang,Mu Liu,Liuzhao Cao et al.
Xiujuan Wang et al.
This review systematically summarizes the key pathological mechanisms and therapeutic potential of the gut microbiota-neuroinflammation axis in comorbid depression in epilepsy. Approximately 30-50 % of epilepsy patients suffer from depressi...
Inflammatory profiles of transdiagnostic symptom dimensions in healthy females [0.03%]
健康女性共病症状维度的炎症特征分析
Alicia J Smith,Stacey Kigar,Quentin Dercon et al.
Alicia J Smith et al.
Background: Psychiatric disorders are increasingly conceptualised as heterogeneous categories with transdiagnostic underlying mechanisms that cut across multiple diagnoses and vary within a single diagnosis. Inflammation ...
Early brain changes in Lyme disease are associated with clinical outcomes [0.03%]
早发性大脑变化与莱姆病的临床症状有关
Cherie L Marvel,Alison W Rebman,Kylie H Alm et al.
Cherie L Marvel et al.
In Lyme disease (LD), 10-20 % of patients develop persistent symptoms following antibiotic treatment (i.e., post-treatment Lyme disease (PTLD)), which often includes neurological symptoms. This study tested the hypothesis that physiological...
Socio-environmental and health-related factors and their association with longitudinal change in brain neuroimaging markers through the plasma metabolome among UK adults: An additive Bayesian network analysis [0.03%]
英国成年人的社会环境和健康相关因素及其与脑影像标志物纵向变化的联系：一种加性贝叶斯网络分析方法
May A Beydoun,Jordan Weiss,Michael F Gerogescu et al.
May A Beydoun et al.
Socio-environmental and health-related variables were examined in relation to longitudinal change in select neuroimaging markers through metabolomics. Data from 2255 dementia-free UK Biobank participants were utilized. Statistical analyses ...
Glial activation and increase in cerebral pro-inflammatory cytokine expression in a female animal post-COVID model [0.03%]
新冠病毒感染后遗症模型小鼠的胶质细胞活化和脑内促炎症因子表达增加
Silvia Flaj Prados,Esperanza Herradón Pliego,Carlos Goicoechea Garcia et al.
Silvia Flaj Prados et al.
Introduction: Many COVID-19 survivors suffer long-term multi-organ damage leading to some symptoms such as brain fog. Around 25 % of patients report persistent memory loss, concentration difficulties, or other cognitive i...
Gestational stress disrupts the neuroimmune environment in the nucleus accumbens of maternal rats [0.03%]
妊娠压力会破坏母体大鼠伏隔核的神经免疫微环境
Courtney N Dye,Dominic V Franceschelli,Caitlin Goodpaster et al.
Courtney N Dye et al.
Postpartum depression (PPD) affects 20 % of new mothers. Little is known about what contributes to this prevalence, though one of the strongest risk factors for developing PPD is stress during pregnancy. Pregnancy and the postpartum period ...