Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome [0.03%]
新冠后遗症患者的脑结构异常的分子、细胞和网络图谱绘制
Daniel Martins,Ziyuan Cai,Nicole Mariani et al.
Daniel Martins et al.
Post-COVID-19 syndrome encompasses persistent cognitive, neurological, and psychiatric symptoms following SARS-CoV-2 infection, profoundly affecting global quality of life. Clarifying the neurobiological basis of these symptoms is vital for...
CYFIP1 overexpression amplifies IL-6/STAT3 and IFN-γ/STAT1 signaling: potential implications for neuroinflammation and autism spectrum disorder [0.03%]
CYFIP1过表达放大了IL-6/STAT3和IFN-γ/STAT1信号：对神经炎症和自闭症谱系障碍的潜在影响
Emily-Rose Martin,Josan G Martin,Mark A Russell et al.
Emily-Rose Martin et al.
Background and objectives: Autism spectrum disorder (ASD) encompasses a group of neurodevelopmental disorders influenced by genetic and environmental factors, although the molecular mechanisms underlying their interaction...
PCSK9 at the intersection of lipid metabolism, immunometabolism, and psychiatric disorders: A narrative review [0.03%]
PCSK9在脂质代谢、免疫代谢和精神障碍的交集：叙述性综述
Folkert H van Bruggen,Roger S McIntyre
Folkert H van Bruggen
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a central regulator of lipid metabolism and a well-established determinant of cardiovascular risk. In addition to its hepatic role in cholesterol homeostasis, PCSK9 is increasingly li...
The association between high-sensitivity C-reactive protein and depression symptom severity among U.S. adults: A multivariable analysis of NHANES data [0.03%]
美国成人高敏感性C反应蛋白与抑郁症状严重程度之间的关系：NHANES数据分析结果
Jediah Grace Arellano,Eunjung Lim,Chathura Siriwardhana et al.
Jediah Grace Arellano et al.
Background: Systemic inflammation may play a role in depression. This study examined the association between high-sensitivity C-reactive protein (hs-CRP), a well-established biomarker of systemic inflammation, and the sev...
Associations between inflammation markers (CRP and IL-6) and depression among adolescents and young adults in Soweto and Durban, South Africa [0.03%]
南非索韦托和德班青少年和年轻人中炎症标志物(CRP和IL-6)与抑郁症状的相关性研究
Tatiana E Pakhomova,Thumbi Ndung&#x;u,Mark Brockman et al.
Tatiana E Pakhomova et al.
Objectives: Previous research has shown an association between inflammation and the development of depression. We examined the relationship between biomarkers of inflammation and probable depression among South African yo...
Cognition at the core of metabolic syndrome: linking metabolic load to behavioural impairment in a longitudinal high-fat diet rat model [0.03%]
代谢综合征的认知核心：在高脂饮食大鼠模型中将代谢负荷与行为损害联系起来
Nicolò Ricciardi,Valentina Di Liberto,Danila Di Majo et al.
Nicolò Ricciardi et al.
Metabolic dysfunction severely affects brain physiology; however, the progression of cognitive and affective alterations and their causal relationship with systemic dysmetabolism driving metabolic syndrome (MetS) have to be fully elucidated...
Identification of autoantibodies against L1CAM in patients with schizophrenia [0.03%]
精神分裂症患者中针对L1CAM自身抗体的鉴定
Shingo Katayama,Yukiko Motokawa,Gayatri Nayanar et al.
Shingo Katayama et al.
Synaptic autoantibodies have been implicated in the pathophysiology of a subset of schizophrenia cases. The identification of novel autoantibodies in schizophrenia may therefore provide insights into previously unrecognized disease mechanis...
A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving [0.03%]
儿童Bugs研究协议：整合多组学方法，理解早期不良养育后的肠道微生物组和中导 limbic系统在青少年精神健康中的作用
Genesis D Flores,Zoe F Damon,Mary Ford et al.
Genesis D Flores et al.
Caregiving-related early adversities (crEAs) are potent risk factors for the development of internalizing psychopathology (e.g., depression, anxiety). Alterations to the dopaminergic mesocorticolimbic system, which supports the construction...
From case-control averages to validated subgroups: Interpreting inflammatory and neuroaxonal-injury biomarkers in schizophrenia and major depression [0.03%]
从病例对照平均值到验证亚组：精神分裂症和重大抑郁症中炎症和神经轴突损伤生物标志物的解读
Paul C Guest,Janet L Cunningham,Florian Raabe et al.
Paul C Guest et al.
Psychiatric biomarker research is characterized by subtle but potentially informative biological signals that often lie close to methodological noise. Compared with neurodegenerative or infectious diseases, candidate blood and cerebrospinal...
Maternal health behavior during pregnancy mediates the relationship between maternal stress and newborn telomere length [0.03%]
孕期母亲健康行为介导了母体压力与新生儿端粒长度的关系
Karin de Punder,Malvika Godara,Niklas Speckle et al.
Karin de Punder et al.
Background: Health behaviors play a key role in age-related disease risk and are influenced by psychosocial stress. The period of embryonic and fetal life represents among the most sensitive developmental windows at which...