Lennart Seizer,Johanna Löchner,Tobias J Renner
Lennart Seizer
The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This s...
Distinct actions of the humid heat environment on host gut microbiota, intestinal mucosal immunity, neuroendocrinology in influenza A virus-infected mouse [0.03%]
湿度热应激通过宿主肠道微生物群、肠黏膜免疫和神经内分泌影响甲型流感病毒感染小鼠的机制研究
Sizhi Wu,Yiwen Lv,Peng Pang et al.
Sizhi Wu et al.
Background: Climate factors exert a profound influence on human emotional well-being and physical health. Exposure to a humid heat environment is known to precipitate anxiety-like behaviors and exacerbate the clinical man...
Neuroinflammation and insulin resistance in major depression and bipolar disorder: Implications for clinical trials evaluating immunometabolic targeted therapies [0.03%]
抑郁症和双相情感障碍中的神经炎症与胰岛素抵抗：针对免疫代谢靶向治疗的临床试验的启示
Folkert H van Bruggen,Roger S McIntyre
Folkert H van Bruggen
Bipolar disorder (BD) and major depressive disorder (MDD) are highly prevalent, disabling psychiatric illnesses marked by substantial heterogeneity and frequent metabolic and inflammatory comorbidities. Growing evidence implicates low-grade...
Effects of combined prenatal exposure to air pollution and maternal stress on immune and dopaminergic gene expression in the gut-brain axis [0.03%]
孕期联合作用暴露于空气污染和母体压力对肠道-大脑轴免疫和多巴胺基因表达的影响
Elise M Martin,Matthew J Morales,Niki Y Li et al.
Elise M Martin et al.
Air pollution and maternal stress during pregnancy are both risk factors for neurodevelopmental disorders and often converge on the same communities. Epidemiological and animal studies suggest that maternal psychosocial stress may worsen th...
Levels of matrix metalloproteinase 9 (MMP-9) are elevated in persons with major depressive disorder who have had a recent suicide attempt [0.03%]
近期有自杀企图的重大抑郁症患者的基质金属蛋白酶9(MMP-9)水平升高
Faith Dickerson,Emily Katsafanas,Andrea Origoni et al.
Faith Dickerson et al.
Matrix metalloproteinases (MMPs) are a diverse set of enzymes associated with tissue remodeling as well as inflammation and tissue destruction. MMP-9 is of interest since it has been associated with psychiatric disorders including major dep...
Self-reported health and health literacy, neuroplasticity and neuro-immunological markers during the first 12 months in newly diagnosed people living with HIV: An exploratory study [0.03%]
HIV新近诊断患者的自我报告健康状况和健康素养、神经可塑性及神经免疫学标志物的探索性研究
Bengt B Arnetz,Judith E Arnetz,Norbert Kaminski et al.
Bengt B Arnetz et al.
Background: There is limited description of dynamic changes in stress, inflammation, neuroplasticity, and health literacy during the early phase of HIV infection. This study examined patterns in self-reported stress, neur...
A systematic review of the neurobiological mechanisms of chemotherapy-induced deficits in executive functions [0.03%]
关于化疗引起的执行功能缺陷的神经生物学机制的系统回顾
Weiye Chen,Ian N Johnston
Weiye Chen
A subset of cancer patients and survivors experience cognitive decline during and after chemotherapy, a condition known as chemotherapy-induced cognitive impairment (CICI). Among the most affected domains are executive functions (EFs) - a s...
Therapeutic nanoliposome vaccine targeting multiple Aβ and tau epitopes reduces AD-like brain pathologies and rescues cognitive deficits in 3xTg-AD mice [0.03%]
靶向Aβ和tau多表位的治疗性纳米脂质体疫苗可减少3xTg-AD小鼠的阿尔茨海默病样脑病理并挽救认知缺陷
Chun-Ling Dai,Yiting Song,Yonghua Chen et al.
Chun-Ling Dai et al.
Amyloid beta (Aβ) plaques and hyperphosphorylated tau neurofibrillary tangles (NFTs) are the histopathological hallmarks of Alzheimer's disease (AD) and targets for AD therapeutics. Since Aβ and tau pathologies both drive AD pathogenesis ...
Perceived stress precedes declines in Well-being: A prospective study of stress, well-being, hair cortisol, and low-grade inflammation in hospital employees [0.03%]
压力感知先于幸福感的下降：医院员工的压力、幸福感、头发皮质醇和低度炎症的前瞻性研究
Monica T Jones,Rachael A Cronin,Mathew D Marques et al.
Monica T Jones et al.
Objective: Chronic low-grade inflammation may help explain the relationship between stress, well-being, and disease, but the pathway and temporal order have not yet been tested prospectively. To understand the pathways be...
Psychological distress predicts disease activity in inflammatory bowel disease: Results from the mind-body IBD longitudinal study [0.03%]
心理压力可预测炎症性肠病的疾病活动度：来自身心炎症性肠病纵向研究的结果
Natasha Seaton,Joanna L Hudson,Valeria Mondelli et al.
Natasha Seaton et al.
Background & aims: Psychological distress (depression, anxiety, stress) is common in inflammatory bowel disease (IBD) and is linked to poorer outcomes, yet behavioural pathways and economic consequences remain unclear. Th...