Beyond the neuro-immune interplay in depression: Could gut microbes be the missing link? [0.03%]
超越抑郁症中的神经免疫相互作用：肠道微生物可能是缺失的环节吗？
Marie-Claude Audet
Marie-Claude Audet
Accumulating evidence have positioned inflammatory signaling pathways as crucial routes by which microbes inhabiting the gastrointestinal tract (the gut microbiota) communicate with the host brain to influence behavior, with impacts on ment...
Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier [0.03%]
使用人类血脑屏障的体外模型研究白细胞介素-1抑制剂的转运
Elisabet O Sjöström,Maxime Culot,Lisa Leickt et al.
Elisabet O Sjöström et al.
The proinflammatory cytokine Interleukin-1 (IL-1), with its two isoforms α and β, has important roles in multiple pathogenic processes in the central nervous system. The present study aimed to evaluate and compare the blood-to-brain distr...
ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5 [0.03%]
缺乏唾液酸转移酶ST3GAL5的小鼠表现出类似ASD的行为，炎症反应失调和PLP1表达降低
Tatyana Strekalova,Evgeniy Svirin,Ekaterina Veniaminova et al.
Tatyana Strekalova et al.
Gangliosides are glycosphingolipids, which are abundant in brain, are known to modulate ion channels and cell-to-cell communication. Deficiencies can result in aberrant myelination and altered immune responses, which can give rise to neurod...
Enteral enriched nutrition to prevent cognitive dysfunction after surgery; a study in rats [0.03%]
肠内富营养化以预防手术后的认知功能障碍；大鼠研究
Iris B Hovens,Barbara L van Leeuwen,Joana Falcao-Salles et al.
Iris B Hovens et al.
Background: Inflammation plays an important role in postoperative cognitive dysfunction (POCD), particularly in elderly patients. Enteral enriched nutrition was shown to inhibit the response on inflammatory stimuli. Aim o...
Maternal immune activation alters the sequential structure of ultrasonic communications in male rats [0.03%]
母体免疫激活改变雄性大鼠超声通讯的序列结构
Kieran Jack Scott,Faezeh Tashakori-Sabzevar,David K Bilkey
Kieran Jack Scott
Maternal immune activation (MIA) is a risk factor for schizophrenia and many of the symptoms and neurodevelopmental changes associated with this disorder have been modelled in the rodent. While several previous studies have reported that ro...
Transdiagnostic biomarker approaches to mental health disorders: Consideration of symptom complexity, comorbidity and context [0.03%]
跨诊断的精神健康障碍生物标志物方法：考虑症状的复杂性、共病性和背景因素
Robyn J McQuaid
Robyn J McQuaid
Depression is a multifaceted disorder characterized by heterogeneous symptom profiles and high rates of comorbidity with other commonly occurring mental illnesses. Considering the burden of mental health disorders and the lack of efficacy o...
Beyond social withdrawal: New perspectives on the effects of inflammation on social behavior [0.03%]
超越社会退缩：炎症对社会行为影响的新视角
Keely A Muscatell,Tristen K Inagaki
Keely A Muscatell
Decades of research in animals and humans show that inflammation is an important regulator of social behavior. While much research in this area has concluded that inflammation causes a withdrawal from social interaction, closer examination ...
Microglial functional alteration and increased diversity in the challenged brain: Insights into novel targets for intervention [0.03%]
受挑战大脑中小胶质细胞功能改变和多样性增加：对干预新靶点的见解
Marie-Ève Tremblay
Marie-Ève Tremblay
Microglia are the resident immune cells of the central nervous system (CNS) parenchyma, which perform beneficial physiological roles across life. These immune cells actively maintain CNS health by clearing toxic debris and removing dysfunct...
Social media use and systemic inflammation: The moderating role of self-esteem [0.03%]
社交媒体使用与系统性炎症：自尊的调节作用
David S Lee,Baldwin M Way
David S Lee
Social media use has become an important part of social life. However, little is known about its relation to physical health. Extending prior work on social media use and psychological well-being, the present research investigated how socia...
Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study [0.03%]
远程缺血预处理对人类固有免疫的神经调节：实验交叉研究
Shaun M May,Eric Chiang,Anna Reyes et al.
Shaun M May et al.
Experimental animal studies on the mechanisms of remote ischaemic conditioning (RIC)-induced cardioprotection against ischaemia/reperfusion injury demonstrate involvement of both neuronal and humoral pathways. Autonomic parasympathetic (vag...