Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis [0.03%]
脑血管病和血管性认知障碍中神经血管单元的液体生物标志物：系统评价和meta分析
Gurpreet Kaur Hansra,Tharusha Jayasena,Satoshi Hosoki et al.
Gurpreet Kaur Hansra et al.
Background: The disruption of the neurovascular unit (NVU), which maintains the integrity of the blood brain barrier (BBB), has been identified as a critical mechanism in the development of cerebrovascular and neurodegene...
Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA) [0.03%]
站立后血压恢复速度较慢与大脑加速衰老有关：来自爱尔兰老龄化纵向研究（TILDA）的证据
Morgana A Shirsath,John D O&#x;Connor,Rory Boyle et al.
Morgana A Shirsath et al.
Background: Impaired recovery of blood pressure (BP) in response to standing up is a prevalent condition in older individuals. We evaluated the relationship between the early recovery of hemodynamic responses to standing ...
Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial [0.03%]
全科医生和记忆诊所病人对衰老和认知减退的看法，以告知分散的抗高血压痴呆预防试验的设计
Alexandra Hurden,Isabella Cotter,Loren Mowszowski et al.
Alexandra Hurden et al.
Background: The global burden dementia is growing each year. Clinical trials investigating approaches to preventing dementia have been occurring for decades, but they are particularly challenging including the requirement...
What matters to people and families affected by cerebral small vessel disease (SVD)? A qualitative grounded theory investigation [0.03%]
小血管疾病(SVD)对人们和家庭的影响是什么？一项定性基础理论研究
Sophia Wong Ching Hwai,Joanna M Wardlaw,Anna Williams et al.
Sophia Wong Ching Hwai et al.
Background: Cerebral small vessel disease (SVD) is a common neurological disorder contributing to stroke, dementia, and disability. No treatment options exist although clinical trials are ongoing. We aimed to understand w...
A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [0.03%]
肾上腺髓质素治疗伴皮质下梗死和白质脑病的常染色体显性遗传脑动脉病的二期单臂临床实验研究
Kazuo Washida,Satoshi Saito,Tomotaka Tanaka et al.
Kazuo Washida et al.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary cerebral small vessel disease (SVD), currently lacks disease-modifying t...
The Luigi Sacco Hospital VAS-COG stroke care pathway: A five-year experience [0.03%]
路易吉·萨科 (Luigi Sacco) 医院的VAS-COG卒中护理路径：五年经验
I Cova,F Mele,A Nicotra et al.
I Cova et al.
Background: Psycho-cognitive consequences are a frequent cause of disability in stroke survivors but are often underdiagnosed also because of lack of services dedicated to these aspects. We started assessing systematicall...
Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia [0.03%]
脉压和APOE ε4剂量相互影响非痴呆老年人的脑血流量
Lauren Edwards,Kelsey R Thomas,Alexandra J Weigand et al.
Lauren Edwards et al.
This study assessed whether the effect of vascular risk on cerebral blood flow (CBF) varies by gene dose of apolipoprotein (APOE) ε4 alleles. 144 older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative underwent ...
Philip B Gorelick,Atticus H Hainsworth,Anders Wallin
Philip B Gorelick
Brain health initiatives and programs are gaining traction worldwide. Some are clinically based, others research based, and some are a combination of clinical and research action plans. Achievement of global brain health is a challenging en...
Acute cerebral microbleeds detected on high resolution head CT presenting with transient neurologic events [0.03%]
头部高分辨率CT检查发现的急性脑微出血伴一过性神经症状
Abdullah Tawakul,Arturo R Toro,José Rafael Romero
Abdullah Tawakul
Introduction: Cerebral microbleeds (CMBs) are deposits of hemosiderin-laden macrophages that can be visualized on T2-weighted MRI sequences as small, ovoid areas of signal void. These markers represent hemorrhagic cerebra...
Examining the relationship between anxiety and regional brain volumes in the National Alzheimer's Coordinating Center uniform, imaging, and biomarker datasets [0.03%]
使用全国老年痴呆协调中心统一成像和生物标志物数据集检查焦虑与脑区体积的关系
Shanna L Burke,Adrienne Grudzien,Tan Li et al.
Shanna L Burke et al.
Anxiety has been associated with a greater risk of Alzheimer's disease (AD). Existing research has identified structural differences in regional brain tissue in participants with anxiety, but results have been inconsistent. We sought to det...