The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial [0.03%]
有氧运动对血管性认知障碍患者脑血流影响的随机对照试验（Excersion-VCI试验）
Liz R van Hout,Justine Moonen,Annebet E Leeuwis et al.
Liz R van Hout et al.
Aerobic exercise may improve cerebral perfusion and may thereby attenuate, or delay, cognitive decline. Excersion-VCI aimed to evaluate the effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment (VCI...
Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population [0.03%]
多族裔人群中心血管危险因素与脑血流的关联研究
Esther M C Vriend,Mathijs B J Dijsselhof,Thomas A Bouwmeester et al.
Esther M C Vriend et al.
Background: Cardiovascular (CV) risk factors are associated with cerebrovascular damage and cognitive decline in late-life. However, it is unknown how different ethnic CV risk profiles relate to cerebral haemodynamics in ...
The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study [0.03%]
单基因和散发性小血管病患者中脑小血管功能与白质微结构的关系- ZOOM@SVDs研究
Naomi Vlegels,Hilde van den Brink,Anna Kopczak et al.
Naomi Vlegels et al.
In cerebral small vessel disease (cSVD), vascular dysfunction has been associated with cSVD-lesions across the brain. Here we further explore the relation between vascular dysfunction and cSVD-related brain injury. We tested two hypotheses:...
Advantages and challenges of using arterial spin labelling MRI to monitor cerebral blood flow in multi-centre clinical trials of neurodegenerative disease: Comment [0.03%]
动脉自旋标记MRI在神经退行性疾病多中心临床试验中监测脑血流的优势和挑战：评述
Hinpetch Daungsupawong,Viroj Wiwanitkit
Hinpetch Daungsupawong
•More research should be performed on how to deal with variances in MRI machines and imaging settings across several locations. Using higher resolution imaging techniques or creating statistical methods to adjust results to account for var...
Permutations of cerebrovascular pathologies in older adults with and without diabetes [0.03%]
糖尿病患者和非糖尿病患者的老年人脑血管病病理变化及其排列组合
Rupal I Mehta,Ana W Capuano,Roshni Biswas et al.
Rupal I Mehta et al.
Permutations of cerebrovascular pathologies (CVP) in persons with diabetes mellitus (DM) have not been comprehensively investigated. Here, we examine diverse postmortem CVP outcomes, including permutations of single or mixed CVP, in 2163 ol...
Claire Seigworth,Isabelle Grassl,Dawn F Wolfgram
Claire Seigworth
Introduction Cerebrovascular reactivity (CVR) can inform about cerebral vascular health and provide prognostic information on risk cerebral ischemic injury. Use of transcranial Doppler ultrasound (TCD) is a non-invasive and inexpensive meth...
Electroacupuncture protects against cerebral ischemia-reperfusion injury via regulating P2×7R expression [0.03%]
电针通过调节P2×7R表达对抗脑缺血-再灌注损伤
Sijia Chen,Ye Zhu,Feihong Lin et al.
Sijia Chen et al.
Background: Ischemic stroke is a serious clinical condition that is challenging to cure; therefore, slowing down the depletion of ATP is crucial to enhancing the tolerance of ischemic tissue through preconditioning. Elect...
Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers [0.03%]
载脂蛋白E4携带者内皮祖细胞和脑小血管病
Arunima Kapoor,Shubir Dutt,Amy Nguyen et al.
Arunima Kapoor et al.
APOE4 carriers at genetic risk for Alzheimer's disease exhibit early cerebrovascular dysfunction, which may be triggered by endothelial dysfunction. Endothelial progenitor cells (EPCs) represent cell populations involved in promoting angiog...
The health and economic burden of brain disorders: Consequences for investment in diagnosis, treatment, prevention and R&D [0.03%]
脑疾患的健康和经济负担：对诊断、治疗、预防及研发投资的影响
Yunfei Li,Linus Jönsson
Yunfei Li
Brain disorders are prevalent across all age groups but particularly in the elderly, highlighting the importance of preserving brain health in ageing populations. There have been few previous studies to address the complete scope of burden ...
Advantages and challenges of using arterial spin labelling MRI to monitor cerebral blood flow in multi-centre clinical trials of neurodegenerative disease: Experience from the RADAR study [0.03%]
多中心神经退行性疾病临床试验中使用动脉自旋标记MRI监测脑血流的优势和挑战——来自RADAR研究的经验
Lina Jarutyte,Jan Petr,Nicholas Turner et al.
Lina Jarutyte et al.
Arterial spin labelling (ASL) enables non-invasive quantification of regional brain perfusion using MRI. ASL was used in the Reducing Pathology in Alzheimer's Disease through Angiotensin TaRgeting (RADAR) multi-centre trial to pilot the ass...