Translational neurophysiological biomarkers of N-methyl-d-aspartate receptor dysfunction in serine racemase knockout mice [0.03%]
.serine racemase基因敲除小鼠N-甲基-D天冬氨酸受体功能障碍的神经生理生物标志物
Andrea Balla,Stephen D Ginsberg,Atheir I Abbas et al.
Andrea Balla et al.
Alterations in glutamatergic function are well established in schizophrenia (Sz), but new treatment development is hampered by the lack of translational pathophysiological and target engagement biomarkers as well as by the lack of animal mo...
Psychomotor Slowing in Schizophrenia: Implications for Endophenotype and Biomarker Development [0.03%]
精神分裂症中的运动迟缓：对内表型和生物标志物开发的影响
K Juston Osborne,Sebastian Walther,Stewart A Shankman et al.
K Juston Osborne et al.
Motor abnormalities (e.g., dyskinesia, psychomotor slowing, neurological soft signs) are core features of schizophrenia that occur independent of drug treatment and are associated with the genetic vulnerability and pathophysiology for the i...
Treatment Response Biomarkers in Anxiety Disorders: From Neuroimaging to Neuronally-Derived Extracellular Vesicles and Beyond [0.03%]
焦虑障碍的治疗反应生物标志物：从神经影像学到神经源性细胞外囊泡及更多方面
Jeffrey R Strawn,Amir Levine
Jeffrey R Strawn
Multiple and diverse psychotherapeutic or psychopharmacologic treatments effectively reduce symptoms for many patients with anxiety disorders, but the trajectory and magnitude of response vary considerably. This heterogeneity of treatment r...
Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development [0.03%]
精神分裂症前额叶皮质谷氨酸和γ-氨基丁酸神经传递功能的改变：合理开发生物标志物的新思路
Kirsten E Schoonover,Samuel J Dienel,David A Lewis
Kirsten E Schoonover
Certain cognitive deficits in schizophrenia, such as impaired working memory, are thought to reflect alterations in the neural circuitry of the dorsolateral prefrontal cortex (DLPFC). Gamma oscillations in the DLPFC appear to be a neural co...
Complement component 3 levels in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder [0.03%]
重大抑郁障碍的无认知损害老年患者的脑脊液补体成分3水平
Anilkumar Pillai,Davide Bruno,Jay Nierenberg et al.
Anilkumar Pillai et al.
Late-life major depression (LLMD) is a risk factor for the development of mild cognitive impairment and dementia, including Alzheimer's disease (AD) and vascular dementia. Immune dysregulation and changes in innate immune responses in parti...