Evaluation of a hypothesized Sertoli cell-based adverse outcome pathway for effects of diisononyl phthalate on the developing testis [0.03%]
隔宫细胞假定的不利影响途径在偏苯三甲酸二异壬酯对睾丸的影响中的评价
J M Rogers,A N Buerger,M M Heintz et al.
J M Rogers et al.
Exposure of pregnant rats to some phthalates during the masculinization programming window (MPW) can lower fetal testis testosterone production and adversely affect development of the fetal male reproductive tract. Some of the effects in ra...
The impact of in utero tobacco exposure on smoking behaviors, cardiovascular disease risk and all-cause mortality in adulthood: A UK Biobank study [0.03%]
子宫内烟草暴露对成年期吸烟行为、心血管疾病风险及全因死亡率的影响：英国生物样本库研究
Yanxu Zheng,Xinyu Xiong,Jing Bao et al.
Yanxu Zheng et al.
The knowledge regarding the negative impacts of in utero tobacco exposure (IUTE) on cardiovascular disease (CVD) was incomplete. This study aims to assess the association between IUTE and the risks of CVD incidence and all-cause mortality, ...
Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms [0.03%]
基于社区了解内分泌干扰物与抑郁症状的关联
Yun-An Liu,Heng-Jung Hsu,Heng-Chih Pan et al.
Yun-An Liu et al.
Background: The rising prevalence of depressive disorders has sparked concerns regarding environmental risk factors, particularly exposure to endocrine-disrupting chemicals (EDCs). However, the link between EDC exposure a...
Evaluation of the endocrine disrupting potential of Di-isononyl phthalate [0.03%]
Di-isononyl phthalate的内分泌干扰潜能评估
I A Lea,A N Buerger,D Feifarek et al.
I A Lea et al.
Low molecular weight ortho-phthalate compounds have been implicated in disruption of androgen pathways when exposure occurs during the masculinization programming window. Di-isononyl phthalate (DINP) is a high molecular weight phthalate and...
Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in humans based on animal cancer studies and mechanistic data [0.03%]
基于动物癌症研究和机制数据，系统评估甲基叔丁基醚的证据基础，支持其对人类致癌风险无需关注的观点
S J Borghoff,B N Rivera,S Fitch et al.
S J Borghoff et al.
Methyl tert-butyl ether (MTBE) is a high-octane fuel component that helps gasoline burn cleaner and reduces automobile emissions. In 1999, the International Agency for Research on Cancer (IARC) categorized MTBE as "not classifiable" regardi...
Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate [0.03%]
Di-isodecyl phthalate的内分泌干扰潜力的评估
I A Lea,D Feifarek,A Mihalchik et al.
I A Lea et al.
Low molecular weight ortho-phthalates have been implicated in perturbing androgen pathways when administered during the masculinization programming window. Di-isodecyl phthalate (DIDP) is a high molecular weight phthalate and as a high prod...
A computational dynamic systems model for in silico prediction of neural tube closure defects [0.03%]
用于预测体内神经管闭合缺陷的计算动态系统模型
Job H Berkhout,James A Glazier,Aldert H Piersma et al.
Job H Berkhout et al.
Neural tube closure is a critical morphogenetic event during early vertebrate development. This complex process is susceptible to perturbation by genetic errors and chemical disruption, which can induce severe neural tube defects (NTDs) suc...
New approach methodologies to assess wanted and unwanted drugs-induced immunostimulation [0.03%]
评估预期和非预期药物诱导免疫刺激的新方法论
Valeria Bettinsoli,Gloria Melzi,Irene Marchese et al.
Valeria Bettinsoli et al.
This review examines various classes of drugs, focusing on their therapeutic and adverse effects, particularly in relation to immunostimulation. We emphasize the potential of new approach methodologies (NAMs) to study both expected and unex...
John T Gamble,Chad Deisenroth
John T Gamble
The U.S. Environmental Protection Agency (U.S. EPA) is mandated to develop new approach methods (NAMs) to detect chemicals risks to susceptible populations, including effects on pregnant women and their offspring. With limited hazard inform...
An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing [0.03%]
一种自动化平台同时用于工程神经肌肉组织的纵向分析以应用于神经毒素效力测定
Jacob W Fleming,Molly C McCloskey,Kevin Gray et al.
Jacob W Fleming et al.
Animal models of the neuromuscular junction (NMJ) have been widely studied but exhibit critical differences from human biology limiting utility in drug and disease modelling. Challenges with scarcity, scalability, throughput, and ethical co...