Food preservative tBHQ modulates Th17/Treg balance through AHR/NRF2 xenosensors and increases the sensitivity of T cells to activation stimuli [0.03%]
食品防腐剂tBHQ通过AhR/Nrf2异物传感器调节Th17/Treg平衡并增加T细胞活化刺激的敏感性
Zoltán Palczert,Krisztina Németh,Nóra Fekete et al.
Zoltán Palczert et al.
In this study, we investigated the effect of the food preservative tert-butylhydroquinone (tBHQ) on the activation of murine CD4+ T cells. We assessed the role of the nuclear factor erythroid 2-related factor 2 (NRF2) and the aryl hydrocarb...
Mechanisms of neurotoxicity of fluoride or aluminum: implications for neurodegenerative disease risk [0.03%]
氟和铝的神经毒性机制：对神经退行性疾病风险的意义
Zhilin Wang,Tracie R Baker,Ashley J Malin
Zhilin Wang
Fluoride and aluminum are two naturally abundant elements with widespread industrial uses. Fluoride is also added to community water supplies as a public health intervention for dental cavity prevention. However, findings from animal studie...
Developmental lead (pb) exposure induces anxiety and depression-like behaviors via inhibiting the AMPK/ACSS2 pathway [0.03%]
发育期铅暴露通过抑制AMPK/ACSS2途径诱发焦虑及抑郁样行为
Mengqin Tao,Shu Ai,Xiaozhen Gu et al.
Mengqin Tao et al.
Environmental lead (Pb) exposure is a risk factor for anxiety and depression. Our previous study showed Pb-induced neurotoxicity involves dysregulated epigenetic modifiers, yet the role of acyl-CoA synthetase short-chain family member 2 (AC...
CC16 alleviates PM2.5-induced airway inflammation in asthmatic mice by targeting the E-cadherin-mediated ferroptosis regulatory axis [0.03%]
CC16通过靶向E-钙黏蛋白介导的铁死亡调节轴缓解PM₂.₅诱导的哮喘小鼠气道炎症
Aili Wang,Shuo Yang,Fang Xu et al.
Aili Wang et al.
Airway epithelial ferroptosis is critically involved in PM2.5-driven asthmatic airway damage, and our previous studies have demonstrated the protective role of club cell protein 16 (CC16) against fine particulate matter (PM2.5)-induced airw...
Subchronic low dose dioxin exposure disrupts hepatic and metabolic homeostasis in a sex- and diet-dependent manner [0.03%]
二噁英暴露影响肝脏及代谢稳态的性别和饮食依赖性研究
Oluwanifemi E Bolatimi,Yuan Hua,Gavin J Phillips et al.
Oluwanifemi E Bolatimi et al.
Persistent organic pollutants (POPs) such as "dioxins" have been associated with liver disease development. Population studies have highlighted sex-specific susceptibility to POP-induced liver damage, yet toxicological models looking at sex...
Editorial: Pluripotent stem cells in discovery and mechanistic toxicology [0.03%]
社论：多能干细胞在毒理学发现和机制研究中的作用
David G Belair
David G Belair
Advancing Developmental and Reproductive Toxicity Research: Mechanistic Coverage, NAM Approaches, and Integrative Strategies [0.03%]
发育与生殖毒性研究进展：机制覆盖、NAM方法和集成策略
Junichi Tasaki,Yuhei Nishimura
Junichi Tasaki
In vitro analysis of the anticancer and antimicrobial potentials and phytochemical profiles of leaf extracts from five Vachellia species [0.03%]
五种金合欢叶提取物的体外抗癌、抗菌潜力及植物化学成分分析
Garland Kgosi More,Chimdi Mang Kalu,Yvan Anderson Ngandjui Tchangoue et al.
Garland Kgosi More et al.
The prevalence of antimicrobial resistance and cancer is on the rise, and these ailments create difficulties in therapeutic management and patient compliance. Hence, this necessitates the discovery of novel, less toxic, bioactive compounds ...
Downregulation of lactosylceramide synthases B4GALT5 or B4GALT6 alters glycosphingolipid profiles and enhances oxaliplatin sensitivity in colon cancer cells [0.03%]
乳糖 ceramide 合酶 B4GALT5 或 B4GALT6 的下调改变糖脂谱型并增强结肠癌细胞对奥沙利铂的敏感性
Barbora Lujka,Tereza Šošolíková,Gerardo Vázquez-Gómez et al.
Barbora Lujka et al.
Glycosphingolipids (GSLs) represent an important group of bioactive lipids that serve both as structural components of membranes, and as signaling molecules involved in the regulation of numerous biological processes, such as control of cel...
YanLing Yang,Huan Liang,Yi Liu et al.
YanLing Yang et al.
Oral nicotine products are a category of novel tobacco products that deliver nicotine through oral consumption. With increasing tobacco control measures worldwide and growing public health awareness, its safety risk has gained attention. Ho...