Assessing placental transfer and in utero reproductive effects in rats of a short-chained paraffin with in vitro endocrine disrupting properties [0.03%]
短链烷烃类内分泌干扰物的胎盘转运及宫内暴露生殖毒性评估研究
Mikala Melchiors,Anna Kjerstine Rosenmai,Ronan Cariou et al.
Mikala Melchiors et al.
Chlorinated paraffins (CPs) are industrial chemicals detected widely in the environment and human tissues, raising concerns due to their persistence, bioaccumulation, and potential health risks. CPs with lower chlorination or shorter carbon...
Evaluating fumonisin contamination in cattle feed: Impact on animal health, the agriculture industry and regulatory considerations [0.03%]
评估牲畜饲料中伏马菌素的污染问题：对动物健康、农业产业及监管措施的影响
Ashli A Brown,Tim Herrman
Ashli A Brown
In 2001, the US FDA released guidance levels (GLs) for fumonisin (FUM) in corn and corn by-products intended for human and animal consumption. Recent research challenges the conservatism of these GLs for ruminants, particularly for regions ...
Characterization of extracellular vesicles and miRNA released by cerebral organoids [0.03%]
脑器官释放的细胞外囊泡和miRNA的表征
Brian B Silver,Rick Fannin,Kevin Gerrish et al.
Brian B Silver et al.
Environmental toxicants can contribute to the development of several neurodegenerative diseases. However, the mechanisms behind this pathology are still incompletely understood. Prompt diagnosis of impending neurodegeneration is crucial for...
Predicting seizure liability of small molecules using an in vitro multi-electrode array based assay coupled with modeling of brain disposition [0.03%]
基于体外多电极阵列结合脑分布建模的分子致惊厥性的预测研究
David G Belair,Rebecca Kohnken,Rebecca L McCloud et al.
David G Belair et al.
Unintended central nervous system (CNS) effects of small molecule drugs can lead to costly attrition during drug development. CNS liability can be assessed with biochemical assays, as part of routine nonclinical toxicology studies, or via a...
Exploring transcriptomic databases to identify and experimentally validate tissue-specific consensus reference gene for gene expression normalization in BALB/c mice acutely exposed to 2,3,7,8-Tetrachlorodibenzo- p-dioxin [0.03%]
探索转录组数据库，以识别和实验验证急性暴露于2,3,7,8-四氯二苯并对二噁英的小鼠BALB/c组织特异性共识参考基因，用于基因表达归一化
Nour Hammoudeh,Reem Hasan,Mohammad Deeb et al.
Nour Hammoudeh et al.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic compound affecting organs like the liver, kidney, lung, and reproductive systems in mammals. This study outlines a strategy for choosing appropriate HKGs for tissue-specific gene express...
iPSC-derived and Patient-Derived Organoids: Applications and challenges in scalability and reproducibility as pre-clinical models [0.03%]
由诱导多能干细胞和患者衍生的类器官：作为临床前模型的应用和可扩展性及重复性的挑战
Elisa Heinzelmann,Francesco Piraino,Mariana Costa et al.
Elisa Heinzelmann et al.
Recent advancements in stem cell technology have led to the development of organoids - three-dimensional (3D) cell cultures that closely mimic the structural and functional characteristics of human organs. These organoids represent a signif...
Effects of mineral fibres in an in vitro placental syncytiotrophoblast model [0.03%]
矿物纤维对体外胎盘合体滋养层模型的影响
Giovanni Tossetta,Sonia Fantone,Antonio Domenico Procopio et al.
Giovanni Tossetta et al.
It is known that mineral fibres can be found in placental tissues, but their effect is not known on these tissues. BeWo in vitro model of syncytiotrophoblast, the outer layer of maternal-foetal barrier, is necessary to understand if mineral...
Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer [0.03%]
几种姜黄素衍生物的生物信息学研究及其抗卵巢癌细胞毒性作用
Retno Murwanti,Ritmaleni,Navista Sri Octa Ujiantari et al.
Retno Murwanti et al.
Ovarian cancer ranks as Indonesia's third-leading cause of cancer-related death, emphasising the need for innovative treatments. This study combined bioinformatics, molecular docking, and experimental assays to tackle this challenge. We ide...
A long-term mouse testis organ culture system to identify germ cell damage induced by chemotherapy [0.03%]
长期小鼠睾丸器官培养系统，用于识别化疗引起的生殖细胞损伤
Satoshi Yokota,Kiyoshi Hashimoto,Takuya Sato et al.
Satoshi Yokota et al.
We previously developed the acrosin-green fluorescent protein (GFP) transgenic neonatal mouse organ culture system for rapid and accurate assessment of testicular toxicity. This system effectively evaluates drug-induced toxicity in male ger...
Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice [0.03%]
发育期的多氯联苯(PCB)暴露对排尿生理的影响持续到成年，并影响小鼠对膀胱刺激的敏感性
Monica Ridlon,Audrey Spiegelhoff,Conner L Kennedy et al.
Monica Ridlon et al.
Polychlorinated biphenyls (PCBs) are toxicants present in the environment, foodstuff, animal and human tissues. PCBs are linked to numerous adverse health effects; however, impacts of developmental PCB exposure on lower urinary tract functi...