Joydeb Majumder,William L Murphy
Joydeb Majumder
Neurotoxicity studies often depend on traditional cell-based monoculture assays and animal models, which have a number of limitations. In particular, the existing models either lack the appropriate physiological context, do not include a fu...
Comparative acute toxicity of intravenous paclitaxel and sirolimus in rats [0.03%]
紫杉醇和西罗莫司的急性毒性比较研究
Jing Xie,Denise Schuett,Ulrich Speck et al.
Jing Xie et al.
Aim: In view of the exploration of sirolimus (rapamycin) as balloon coating for peripheral intravasal treatment and the reports on unfavorable tolerance of daily low-dose sirolimus, the aim of the study was to investigate...
Corrigendum to "Reproductive cytotoxic and genotoxic impact of polystyrene microplastic on Paracentrotus lividus spermatozoa" [Curr. Res. Toxicol. 22(6) (2024) 100173] [0.03%]
关于“聚苯乙烯微塑料对Paracentrotus lividus精子细胞的生殖毒性和遗传毒性影响”的勘误修正[Curr. Res. Toxicol. 22(6) (2024) 100173]
Filomena Mottola,Maria Carannante,Angela Barretta et al.
Filomena Mottola et al.
[This corrects the article DOI: 10.1016/j.crtox.2024.100173.]. © 2024 The Author(s).
Published Erratum
Current research in toxicology. 2025 Apr 16:8:100185. DOI:10.1016/j.crtox.2024.100185 2025
Corrigendum to "Evaluation of the Endocrine Disrupting Potential of Di-isononyl Phthalate" [Curr. Res. Toxicol. 8 (2025) 100220] [0.03%]
关于“-di-异壬基邻苯二甲酸的内分泌干扰潜力评估”[Curr. Res. Toxicol. 8 (2025) 100220]的勘误表
I A Lea,A N Buerger,D Feifarek et al.
I A Lea et al.
[This corrects the article DOI: 10.1016/j.crtox.2025.100220.]. © 2025 The Author(s).
Published Erratum
Current research in toxicology. 2025 Apr 23:8:100233. DOI:10.1016/j.crtox.2025.100233 2025
Development of a workflow for in vitro on- and off-target cytotoxicity assessment of CAR T cell therapies to support first-in-human clinical trials: An orthogonal approach using human induced pluripotent stem cell-derived cells as a surrogate for normal vital organ systems [0.03%]
用于支持首次人体临床试验的CAR-T细胞治疗的体外靶向和脱靶细胞毒性的评估工作流程的发展：一种使用人类诱导多能干细胞衍生细胞作为正常重要器官系统的替代物的正交方法
Shari Price,Krista G Zindel,Joshua K Overcash et al.
Shari Price et al.
Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer therapy and is showing promise for other non-cancer disease indications. CAR T cells are directed to a target antigen that is overexpressed by tumor cells. On-target t...
Prediction of the classification, labelling and packaging regulation H-statements with confidence using conformal prediction with N-grams and molecular fingerprints [0.03%]
基于N元语法和分子指纹的符合预测法自信地预测分类、标签和包装条例H项标准
Ulf Norinder,Ziye Zheng,Ian Cotgreave
Ulf Norinder
Effective chemical hazard labelling systems are essential for safeguarding human health and the environment as a result of widespread chemical use, and machine-learning models can be used to predict hazard labels efficiently and reduce the ...
Thallium (III) disrupts the cell cycle and induces oxidative DNA damage in human lymphocytes in vitro [0.03%]
铊（Ⅲ）体外干扰人淋巴细胞的细胞周期并诱导氧化性DNA损伤
Alejandra López-Lanuza,Lucila Álvarez-Barrera,Hugo López-Muñoz et al.
Alejandra López-Lanuza et al.
Thallium (Tl) is considered hazardous to health because of its high toxicity and is an emerging contaminant with two oxidation states: Tl (I) and Tl (III). However, the toxicity of Tl and its compounds can be influenced by the oxidation sta...
Hepatocytes derived from human induced pluripotent stem cells: Towards establishing an in vitro model for assessing population variability in hepatotoxicity testing [0.03%]
由人诱导多能干细胞衍生而来的肝细胞：为建立评估人群差异的体外肝脏毒性检测模型而研发
Xiugong Gao,Rong Li,Kayla Campasino et al.
Xiugong Gao et al.
Interindividual differences in response to chemicals have been typically addressed through the use of a 10-fold default "uncertainty" factor. It was only recently that in vitro models emerged to quantitatively assess interindividual variabi...
Differential effect of targeting cisplatin-induced nitrative stress using MnTBAP in auditory and cancer cells [0.03%]
MnTBAP针对顺铂诱导的亚硝化应激在听觉细胞和癌细胞中的差异效应
Shomaila Mehmood,Pankaj Bhatia,Nicole Doyon-Reale et al.
Shomaila Mehmood et al.
Ototoxicity is a major dose-limiting side effect of cisplatin, a highly effective anti-cancer drug used to treat many solid tumors. Oxidative stress plays a central role in mediating cisplatin-induced ototoxicity. However, broad-spectrum an...
Judit Kalman,Yolanda Valcárcel-Rivera,José Luis Martínez-Guitarte
Judit Kalman
Antibiotics, like other pharmaceuticals, are continuously released into the environment as a result of human activities. Although designed to target harmful bacteria, they can also affect non-target organisms in aquatic ecosystems. Standard...