Pulmonary inflammation and immune responses induced by nanocellulose: Insights from in vivo and in vitro models [0.03%]
纳米纤维素引起的肺部炎症和免疫反应：来自体内和体外模型的见解
Katsuhide Fujita,Sawae Obara,Junko Maru et al.
Katsuhide Fujita et al.
The increasing use of nanocellulose (NC), including cellulose nanofibrils (CNFs) and cellulose nanocrystals (CNCs), in industrial, biomedical, and consumer products has raised concerns regarding potential inhalation exposure, as these mater...
GenX induces offspring vascular endothelial ferroptosis by targeting GPX4 for ubiquitination-dependent degradation [0.03%]
反式维生素A衍生物全反式维甲酸通过靶向GPX4依赖的泛素化降解诱导子代血管内皮细胞铁死亡
Jing Li,Yuhui Cui,Chengyi Zheng et al.
Jing Li et al.
GenX, a widely used replacement for PFOA, has become ubiquitously distributed in aquatic ecosystems, soil, and biota, yet its developmental toxicity in offspring is poorly characterized. This study delineates the intergenerational vascular ...
Strategy for reproductive and developmental toxicity (DART) studies for marketing applications in pharmaceutical development [0.03%]
药物开发过程中药政申请所需的生殖和发育毒性(DART)研究策略
Yusuke Kagawa,Takuro Osawa,Naomi Koyama et al.
Yusuke Kagawa et al.
Studies on reproductive toxicity are conducted to assess the effects of chemicals and pharmaceuticals on the reproductive function and fetal development. However, depending on the indication or modality, Fertility and Early Embryonic Develo...
Approach for systematically assessing study reliability and relevance in evaluations of monosodium glutamate safety [0.03%]
系统评估单钠谷氨酸安全性评价中研究可靠性和相关性的方法
William D Klaren,Brianna N Rivera,Amy M Sheppard et al.
William D Klaren et al.
Monosodium glutamate (MSG) is a well-studied food additive. In addition to numerous authoritative assessments of safety, a substantial volume of research is ongoing with MSG; this includes a growing volume of research assessing the ameliora...
Indoor airborne carcinogen synergy in children: systematic interdisciplinary approach to PM2.5-nicotine driven lung tumorigenesis and targeted intervention [0.03%]
儿童室内空气致癌物协同效应：PM2.5-尼古丁驱动的肺肿瘤发生及靶向干预的系统跨学科方法
Boyu Pan,Xiwen Feng,Fujian Jiang et al.
Boyu Pan et al.
The indoor air environment has become an essential environmental factor affecting children's health and safety, among which nicotine and PM2.5, two common combined factors, have become pathogenic factors in indoor area that induce lung canc...
Prenatal linuron exposure disrupts adrenal steroidogenesis and induces adrenal insufficiency in male rat offspring [0.03%]
氯酮农药的宫内暴露扰乱大鼠子代的肾上腺类固醇生成并导致肾上腺皮质功能不全
Duoduo Quan,Yang Cheng,Xinhe Zhou et al.
Duoduo Quan et al.
Linuron, a commonly used agricultural herbicide in certain regions, has raised concerns due to its endocrine toxicity in humans and wildlife. While its gonadal toxicity is established, its direct impact on prenatal adrenal development remai...
Evaluation of the impact of a 8 week exposure to a portable light therapy device, Luminette®, on retinal function assessed by ElectroRetinoGraphy [0.03%]
便携式光源Luminette®对视网膜功能影响的评估——基于8周干预的视觉诱发电位分析
Marie de Deus,Charlotte Petit,Eve Cosker et al.
Marie de Deus et al.
Background: Major depressive disorder (MDD) treatment can be long and difficult to obtain. Thus, alternative non-pharmacological treatments, such as light therapy (LT), are increasingly recommended to treat MDD. For bette...
Microplastics and nanoplastics in the ocular environment: Pathways, toxic effects, and future challenges [0.03%]
微塑料和纳米塑料在眼部环境中的途径、毒性效应及未来挑战
Xiaotong Yu,Na Zhou,Qun Gao et al.
Xiaotong Yu et al.
Micro- and Nanoplastics (MNPs) have emerged as a significant environmental concern due to their widespread distribution and potential toxicity. While extensive research has explored the impacts of MNPs on various human organs, the eye, a pa...
Neural organoids incorporating microglia to assess neuroinflammation and toxicities induced by known developmental neurotoxins [0.03%]
包含小胶质细胞的神经器官芯片评估已知发育性神经毒素诱导的神经炎症和毒性
Nina Y Yuan,William D Richards,Kailyn T Parham et al.
Nina Y Yuan et al.
The use of iPSC-derived complex in vitro 3D cellular constructs is a promising avenue to more accurately predict human neural toxicities and reduce the use of animal models. We have generated a neural organoid model which incorporates iPSC-...
A high-fat diet exacerbates arsenic toxicity in various organs. A systematic review of toxicity and mechanism [0.03%]
高脂肪饮食可加剧砷的毒害作用——系统综述毒性及机制研究
Hoda Vahedi,Fateme Pourmotahari,Ali Akbar Oroojan et al.
Hoda Vahedi et al.
Background: Arsenic contamination in drinking water remains a primary global health concern. Recent evidence indicates that dietary habits, especially high-fat diets, may exacerbate arsenic-induced toxicity. This systemat...