Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans; lack of concern based on animal cancer studies and mechanistic data [0.03%]
乙基叔丁基醚和叔丁醇致癌性的系统评价：基于动物致癌研究和机制数据无需关注
Brianna N Rivera,Isabel A Lea,Seneca Fitch et al.
Brianna N Rivera et al.
Ethyl tert-butyl ether (ETBE), a fuel additive, and tert-butyl alcohol (TBA), a solvent and metabolite of ETBE and methyl tert-butyl ether (MTBE), may be encountered via inhalation, oral, or dermal exposure. This assessment evaluated the hu...
Toxicological impacts and mitigation strategies of food contaminants: a global perspective and comprehensive narrative review [0.03%]
全球视角下的食品污染物毒理学影响及缓解策略综合叙述性回顾
Gudisa Bereda
Gudisa Bereda
Food contaminants-including chemical, biological, physical, allergenic, and radiological agents-pose major global food safety challenges. This review synthesizes evidence from 2014 to 2025 on Food contaminants sources, cellular and molecula...
Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation [0.03%]
通过分析m6A RNA调控缺陷导致的不育探索Schmidtea mediterranea作为生殖毒性的模型的潜力
Junichi Tasaki,Shujie Liu,Labib Rouhana
Junichi Tasaki
Development of alternative methods for analysis of reproductive toxicity is a challenge that requires the characterization of mechanistic endpoints linked to the toxicity. N 6-methyladenosine (m6A) is one of the most prevalent post-transcri...
The JPX/miR-495-3p/BRD4 axis mediates quercetin-induced toxicity via the X-inactivation center in NSCLC [0.03%]
檞皮素通过非小细胞肺癌中的X染色体失活中心诱导毒性的作用机制研究：JPX/miR-495-3p/BRD4轴的作用
Xiaofeng Lou,Jie Wu
Xiaofeng Lou
Background: Emerging evidence underscores the pivotal role of long non-coding RNAs (lncRNAs) as master regulators of oncogenic pathways, positioning them as compelling therapeutic targets in precision oncology. While the ...
Novel dose- and time-dependent toxicity biomarkers of fentanyl/carfentanyl: uncovered by urine-plasma metabolomics for forensics [0.03%]
新型剂量及时间依赖性芬太尼/卡芬太尼毒性生物标志物的尿液和血浆代谢组学研究
Wanting Xie,Shuo Yang,Xin Wang et al.
Wanting Xie et al.
Fentanyl analogs present a significant global risk to public health and safety due to their high abuse potential and related mortality. However, the absence of a structured research framework focused on their clinical pharmacology and toxic...
Microplastics in ovarian function and ozone-based mitigation strategies: Emerging evidence and translational implications [0.03%]
微塑料对卵巢功能的影响及以臭氧为基础的缓解策略：新兴证据及转化应用意义
Zaher Merhi
Zaher Merhi
Microplastics (MPs) are now recognized as pervasive environmental contaminants with emerging evidence of bioaccumulation in the human reproductive system. Recent studies have detected MPs in human follicular fluid, oocytes, placenta, and se...
Areca nut extract exposure disrupts myogenesis and metabolism in C2C12 cells [0.03%]
槟榔提取物对C2C12细胞肌生成和代谢的干扰作用
Chi-Wei Chen,Tsung-Teng Huang,Yan-Ru Chen et al.
Chi-Wei Chen et al.
Areca nut (AN), which is commonly consumed in Southeast Asia, contains bioactive compounds that may influence cellular functions. Accumulating evidence has revealed several health impacts of AN consumption, but the toxicological effects of ...
Ankita Singh,Nadeem Khan G,Mahua Choudhury et al.
Ankita Singh et al.
Phthalates are a group of phthalic acid esters that are commonly used as plasticizers in many consumer products to improve elasticity, transparency, durability, and toughness. Phthalates are also ubiquitously found throughout our environmen...
Analysis of bisphenol A-modulated expression of hypothalamic thyroid, estrogen, and peroxisome proliferator-activated receptors and concurrent mitochondrial dynamics following short-term exposure in mice [0.03%]
短期暴露双酚A后对小鼠下丘脑甲状腺受体、雌激素受体及过氧化物酶增殖激活受体表达的影响及相关线粒体动态变化的分析
Daiana Alymbaeva,Attila Zsarnovszky,Csaba Szabo et al.
Daiana Alymbaeva et al.
Endocrine-disrupting chemicals (EDCs) represent a significant and growing threat to human and animal health, exerting tissue- and concentration-specific effects on endocrine function. This study investigated the acute impact of bisphenol A ...
AOP Report: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia [0.03%]
APO报告：ALDH1A（RALDH）活性降低通过破坏胎儿卵泡生发初筛导致生育力下降
Monica K Draskau,Cassy M Spiller,Eleftheria M Panagiotou et al.
Monica K Draskau et al.
This report describes a novel adverse outcome pathway (AOP) highlighting how the inhibition of aldehyde dehydrogenase 1A (ALDH1A) enzymatic activity can lead to female infertility in mammals through disrupted meiotic entry of fetal germ cel...