The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis [0.03%]
NLRP3抑制剂MCC950通过抑制肺泡巨噬细胞焦亡减轻环境污染物PM2.5诱导的急性肺损伤
Zhuoxiao Han,Ying Han,Ranran Li et al.
Zhuoxiao Han et al.
PM2.5 is a key environmental pollutant that induces inflammatory lung injury. Effective prevention and treatment for PM2.5-induced lung damage remain lacking. This study investigated MCC950's protective role in PM2.5-exposed mice and macrop...
Lethality is local, but survival is systemic: Temporal and multi-organ responses to chlorine gas exposure in a murine model [0.03%]
局部致死，全身受累：氯气吸入小鼠模型的时空调控多器官响应机制研究
Jonathan Boyd,Mackenzie Newman,Heather Connery et al.
Jonathan Boyd et al.
Chlorine gas (Cl2) is a highly toxic chemical associated with both localized lung injury and systemic health effects. While pulmonary damage has been well characterized, the systemic inflammatory and metabolic responses remain poorly unders...
MicroRNA-mediated changes contributing to benzo[a]pyrene toxicity in a 3D respiratory model for asthma [0.03%]
用于哮喘的三维呼吸模型中参与苯并[a]芘毒性的微小核糖核酸介导的变化
Reese M Valdez,Yvonne Chang,Jamie M Pennington et al.
Reese M Valdez et al.
There is increased emphasis on understanding how non-chemical stressors that contribute to inflammation in the lung may influence adverse health outcomes after chemical exposures. Prior studies in an in vitro respiratory model of type 2 ast...
Scoparone induces mitophagy and apoptosis via ROS accumulation in pancreatic cancer cells [0.03%]
黄芩素通过诱导活性氧积累在胰腺癌细胞中诱导线粒体自噬和凋亡
Ningna Weng,Luping Lin,Tong Lin et al.
Ningna Weng et al.
Pancreatic cancer (PC) is one of the deadliest malignancies worldwide. In the present study, we demonstrated that a traditional Chinese medicine extract monomer, scoparone (Scop), significantly inhibited the growth of PC cells both in vitro...
Multigenerational effects of uranium exposure reveal stronger testicular dysregulation in the second generation [0.03%]
铀暴露的多代效应揭示了第二代睾丸调节功能紊乱更严重
Audrey Legendre,Céline Gloaguen,Dimitri Kereselidze et al.
Audrey Legendre et al.
Background: Infertility is a significant public health issue that can be influenced by environmental pollutants. As a radioactive heavy metal and environmental contaminant, uranium has the potential to impact fertility. ...
Identifying androgen receptor antagonists using a metabolically competent high-throughput screening assay [0.03%]
采用代谢能力较强的高通量筛选法鉴定雄激素受体拮抗剂
Caitlin Lynch,Pranav Shah,Jinghua Zhao et al.
Caitlin Lynch et al.
Androgen receptor (AR) is a nuclear receptor with a well-established role in sexual function and development. Modifications in AR can lead to endocrine disruption, cancer, and other diseases, making it imperative to identify compounds that ...
Zearalenone exposure may increase the risk of non-alcoholic fatty liver disease by activating CYP1B1-SCD1 [0.03%]
黄曲霉毒素暴露通过激活CYP1B1-SCD1可能增加非酒精性脂肪肝病的发病风险
Haonan Ruan,Jing Zhang,Yunyun Wang et al.
Haonan Ruan et al.
Zearalenone (ZEN) is an oestrogen-like mycotoxin that widely contaminates food and feed worldwide. Current research suggests that ZEN causes liver injury by disrupting hepatic lipid metabolism. Furthermore, prolonged disturbances in hepatic...
Application to developmental toxicity testing of a novel method for whole-brain imaging of microglia in zebrafish [0.03%]
应用于斑马鱼全脑成像的新方法在发育毒性测试中的应用研究
Mizuki Yuge,Junko Koiwa,Takashi Shiromizu et al.
Mizuki Yuge et al.
Microglia, parenchymal macrophages resident in the central nervous system, regulate brain development by dynamically changing their functional and morphological states in a spatiotemporal-dependent manner. Because the function of microglia ...
Association of serotonin and ergot alkaloids on tissue partitioning and contractile response of bovine blood vessels [0.03%]
血清素和麦角生物碱对牛血管组织分布和收缩反应的相互作用关系研究
Eriton E L Valente,David L Harmon,John May et al.
Eriton E L Valente et al.
Ergot alkaloids can bind serotonin (5-HT) receptors interfering with many physiological functions. However, the mechanism has not been completely established. The objective was to evaluate whether the association of 5-HT and the ergot alkal...
Ca2+-independent cytotoxicity of menthol in the A549 lung cancer cell line [0.03%]
薄荷醇对A549肺癌细胞系的钙离子非依赖性细胞毒性作用
Kenji Takahashi,Toshio Ohta
Kenji Takahashi
Menthol evokes cooling sensations by activating the transient receptor potential melastatin 8 (TRPM8) channel, resulting in relaxing, anti-inflammatory, and analgesic effects when administered through inhalation and topical application. Alt...