Evaluating the potential carcinogenic hazard of diisononyl phthalate in humans via systematic integration of human, animal cancer studies, and mechanistic data [0.03%]
通过人类和动物致癌实验及机制数据的系统整合评估邻苯二甲酸二异壬酯对人的潜在致癌性
Isabel A Lea,Amanda N Buerger,Melissa J Vincent et al.
Isabel A Lea et al.
Diisononyl phthalate (DINP) is a high molecular weight phthalate used in commercial products and polyvinyl chloride production. Herein, a systematic evaluation of DINP evidence streams (i.e., human cancer, animal cancer, and mechanistic dat...
A mechanistic evaluation of the metabolism disrupting potential of methyl tert-butyl ether [0.03%]
甲基叔丁基醚干扰机体代谢的机制评价研究论文
A N Buerger,M J Vincent,S Fitch et al.
A N Buerger et al.
European authoritative and regulatory assessments of endocrine disruption increasingly incorporate evaluation of metabolism disrupting potential, yet there are no regulatory- or authority-validated models or guidance to identify metabolism ...
A novel non-invasive imaging technique for mapping microplastic accumulation and distribution in different organ systems of Indian major carp Labeo rohita (Ham. 1822) [0.03%]
一种新型无创成像技术用于绘制印度鲤鱼（Labeo rohita）体内微塑料累积和分布图谱
Sneha Siwach,Aviral Singh,Soumyadeep Paul et al.
Sneha Siwach et al.
Microplastic (MP) pollution poses an increasing threat to the aquatic ecosystems, yet most existing detection methods remain largely destructive and spatially limited. Here, we present a novel, non-invasive imaging framework integrated with...
Donald L Bjerke,Jin Li,Yuan Gao et al.
Donald L Bjerke et al.
As the cosmetic industry replaces traditional animal safety studies with next generation risk assessment approaches, the approach to safety substantiation for peptides used in cosmetic products must also evolve. While the need to provide as...
An integration of physiological, morphological and biochemical assessments in studying guinea pig models of ototoxicity and otoprotection-a systematic review [0.03%]
生理、形态和生化评估在研究耳毒性与耳保护 Guinea Pig 模型中的整合-系统评价
Yi-Ho Young,Po-Hsuan Wu,Shing-Hwa Liu
Yi-Ho Young
Purpose: This systematic review aims to explore the development and utilization of a comprehensive test battery comprising physiological, morphological, and biochemical assessments in guinea pig models to study mechanisms...
Low-dose arsenic exposure disrupts rat uterine physiology independent of generation of oxidative stress [0.03%]
低砷暴露通过非氧化应激通路干扰大鼠子宫生理功能
Aniruddha Chatterjee,Urmi Chatterji
Aniruddha Chatterjee
Arsenic is known to adversely affect the female reproductive physiology, specifically at environmentally-relevant or accidentally-high doses, mostly by generation of high amounts of reactive oxygen species (ROS). However, the exact molecula...
Determination of the half-life of di(2-ethylhexyl) phthalate (DEHP) in a preterm neonate using blood transfusion as the source of intravenous exposure [0.03%]
利用输血作为静脉内暴露源确定未成熟新生儿中邻苯二甲酸二异辛酯(DEHP)的半衰期
Michael Furlong,Venkata Gupta,Stephanie Galanti et al.
Michael Furlong et al.
In the neonatal intensive care unit (NICU), infants face treatments that convey high-dose exposure to phthalates, a family of ubiquitous endocrine-disrupting organic chemicals. Past research shows that NICU-based phthalate exposure, particu...
The role of autophagy in microwave radiation induced toxicity in iPSC-derived cardiomyocytes [0.03%]
微波辐射诱导的人 iPSC 分化心肌细胞毒性中的自噬作用机制研究
Chenjing Zhang,Zhanming Liu,Yingxin Wang et al.
Chenjing Zhang et al.
This study aims to explore the impact of microwave radiation on the electrophysiological functions of human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and to focus on the critical role and underlying mechanism of autoph...
Bridging the Gap: How environmental exposures compromise male fertility and clinical Outlook [0.03%]
bridging the gap：环境暴露如何影响男性生育力及临床意义展望
Hongxia Chen,Shenglong He,Zhuoran Zhu et al.
Hongxia Chen et al.
The growing prevalence of male infertility has become a significant clinical and public health issue, with environmental exposures increasingly recognized as a major modifiable risk factor. This review synthesizes current evidence within th...
Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence [0.03%]
基于机制证据评估汽车汽油的致癌潜力对人类的影响
Isabel A Lea,Brianna Rivera,Sarah Rogers et al.
Isabel A Lea et al.
Liquid gasoline (CAS 86290-81-5) is produced by the fractional distillation of crude oil, and mainly consists of volatile organic compounds; finished automotive gasoline products may also include various additives. The objective of this stu...