Computational modelling provides insight into the effects of glyphosate on the shikimate pathway in the human gut microbiome [0.03%]
计算模型为除草剂对人类肠道微生物组莽路酸途径的影响提供新见解
Robin Mesnage,Michael N Antoniou
Robin Mesnage
The herbicide active ingredient glyphosate can affect the growth of microorganisms, which rely on the shikimate pathway for aromatic amino acid biosynthesis. However, it is uncertain whether glyphosate exposure could lead to perturbations i...
Sub-chronic dermal exposure to aircraft engine oils impacts the reproductive organ weights and alters hematological profiles of Sprague Dawley rats [0.03%]
航空发动机滑油的亚慢性皮肤暴露对Sprague Dawley大鼠生殖器重量的影响及其对血液学指标的改变
Isaie Sibomana,David R Mattie
Isaie Sibomana
There is little data available for the toxicity of used aircraft engine oils relative to their unused (new) versions. This study was conducted to determine if grade 3 (G3) and 4 (G4) aircraft engine oils in their new states (G3-N and G4-N) ...
Intrauterine exposure to diethylhexyl phthalate disrupts gap junctions in the fetal rat testis [0.03%]
孕期外源性邻苯二甲酸二辛酯(DEHP)暴露对大鼠睾丸胚胎儿发育的影响及其作用机制研究
Mariana Di Lorenzo,Sofia Boeg Winge,Terje Svingen et al.
Mariana Di Lorenzo et al.
Fetal exposure to certain phthalate esters can disrupt testis development in rodents and lead to male reproductive disorders, but with a causal link less certain in humans. Di(2-ethylhexyl) phthalate (DEHP) is one of the most common phthala...
Elizabeth H Pittman,Nigel D&#x;Souza,Taylor N Mathis et al.
Elizabeth H Pittman et al.
The sex of an individual/animal has been shown to play an important role in many biological processes. Furthermore, sex may also be a factor in the way environmental toxicants, such as heavy metals, are handled by organisms. However, the ef...
In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder [0.03%]
宫内和哺乳期间的多氯联苯暴露可引起小鼠膀胱解剖结构变化
Kimberly P Keil Stietz,Conner L Kennedy,Sunjay Sethi et al.
Kimberly P Keil Stietz et al.
Bladder dysfunction, including incontinence, difficulty emptying the bladder, or urgency to urinate is a pervasive health and quality of life concern. However, risk factors for developing these symptoms are not completely understood, and th...
Regulatory Status of Pesticide Residues in Cannabis: Implications to Medical Use in Neurological Diseases [0.03%]
大麻农药残留的监管状况及其在神经疾病医疗应用中的意义
Dorina V Pinkhasova,Laura E Jameson,Kendra D Conrow et al.
Dorina V Pinkhasova et al.
Medical cannabis represents a potential route of pesticide exposure to susceptible populations. We compared the qualifying conditions for medical use and pesticide testing requirements of cannabis in 33 states and Washington, D.C. Movement ...
The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture of polychlorinated biphenyls [0.03%]
暴露于环境相关多氯联苯混合物对小鼠幼年期血清和海马细胞因子水平的影响：性别、基因型和剂量的作用分析
Lauren Matelski,Kimberly P Keil Stietz,Sunjay Sethi et al.
Lauren Matelski et al.
Polychlorinated biphenyls (PCBs) are pervasive environmental contaminants implicated as risk factors for neurodevelopmental disorders (NDDs). Immune dysregulation is another NDD risk factor, and developmental PCB exposures are associated wi...
CTD Anatomy: analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies [0.03%]
基于解剖学的化学引起的表型和暴露分析及其对环境健康研究的影响
Allan Peter Davis,Thomas C Wiegers,Jolene Wiegers et al.
Allan Peter Davis et al.
The Comparative Toxicogenomics Database (CTD) is a freely available public resource that curates and interrelates chemical, gene/protein, phenotype, disease, organism, and exposure data. CTD can be used to address toxicological mechanisms f...
Excessive use of disinfectants against COVID-19 posing a potential threat to living beings [0.03%]
过度使用消毒剂防疫可能威胁生物健康
Dawood Ghafoor,Zafran Khan,Asaf Khan et al.
Dawood Ghafoor et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city of China in late December 2019 and identified as a novel coronavirus disease 2019 (COVID-19). On January 30, the World Health Organization (WHO) declared...
Kevin L Trout,Andrij Holian
Kevin L Trout
Background: Multinucleated giant cells (MGC) are formed by fusion of macrophages in pathological conditions. These are often studied in the context of the foreign body response to biomaterial implants, but MGC formation i...