Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty [0.03%]
罗苏伐他汀在雌性Wistar大鼠进入青春期前暴露后的短期和长期效应
Jorge W F Barros,Karolina S Tonon,Cibele S Borges et al.
Jorge W F Barros et al.
Statins are a class of drugs that act lowering lipid levels by inhibiting cholesterol biosynthesis. Additionally, statins can act by "pleiotropic effects", related to the inhibition of synthesis of the other mevalonate pathway products. Ros...
Histone deacetylase inhibitors prevent H2O2 from inducing stress granule formation [0.03%]
组蛋白去乙酰化酶抑制剂可防止H2O2诱导应力颗粒形成
Siyuan Feng,Jennifer Nichole Daw,Qin M Chen
Siyuan Feng
Reactive Oxygen Species (ROS) are generated as by-products of aerobic metabolism. The production of ROS increases during xenobiotic stress and under multiple pathological conditions. Although ROS are considered harmful historically, mountin...
Lactational exposure to polychlorinated biphenyls is higher in overweight /obese women and associated with altered infant growth trajectory: A pilot study [0.03%]
一项试点研究：体重超标的女性在母乳喂养期间暴露于多氯联苯的风险更高，且会导致婴儿生长轨迹改变
Lindsay Ellsworth,Harlan McCaffery,Sergei Chernyak et al.
Lindsay Ellsworth et al.
Background: Infant exposure to environmental chemicals, such as polychlorinated biphenyls (PCBs), may contribute to developmental programming of long-term metabolic disease risk. PCBs persist given their lipophilicity and...
Acrylamide induces a thyroid allostasis-adaptive response in prepubertal exposed rats [0.03%]
丙烯酰胺诱导的青春期前暴露大鼠甲状腺 allostatic-适应性响应
Viviane Matoso de Oliveira,Fernanda Ivanski,Isabela Medeiros de Oliveira et al.
Viviane Matoso de Oliveira et al.
Some endocrine-disrupting chemicals (EDCs) can affect the endocrine system through covalent interactions with specific sites, leading to deregulation of physiological homeostasis. The acrylamide (AA) present in some fried or baked foods is ...
Hedgehog signal disruption, gonadal dysgenesis and reproductive disorders: Is there a link to endocrine disrupting chemicals? [0.03%]
刺猬信号干扰、卵巢发育不全和生殖障碍：是否与干扰素扰乱化学物质有关？
Hanna K L Johansson,Terje Svingen
Hanna K L Johansson
Developmental exposure to chemicals that can disrupt sex hormone signaling may cause a broad spectrum of reproductive disorders. This is because reproductive development is tightly regulated by steroid sex hormones. Consequently, non-animal...
Verena Kirsch,Tamara Bakuradze,Elke Richling
Verena Kirsch
Lignans are secondary plant constituents with dibenzylbutane skeletons found in cereals, oilseeds, and nuts. Two members of this class, syringaresinol (Syr) and secoisolariciresinol (Seco), occur at relatively high levels in cereals and pro...
Co-culture with mouse embryonic fibroblasts improves maintenance of metabolic function of human small hepatocyte progenitor cells [0.03%]
与小鼠胚胎成纤维细胞共培养可改善人小肝祖细胞代谢功能的维持
Srikumar Sengupta,Brian Johnson,Morten Seirup et al.
Srikumar Sengupta et al.
Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of proliferating in vitro has been described in rodents and recently in humans. These cells are capable of engrafting in injured livers, however, they display de-di...
Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors [0.03%]
基于多个供体的三维肺上皮培养物的基本形态和功能比较分析
David Bovard,Albert Giralt,Keyur Trivedi et al.
David Bovard et al.
In vitro models of the human lung play an essential role in evaluating the toxicity of inhaled compounds and understanding the development of respiratory diseases. Three-dimensional (3D) organotypic models derived from lung basal epithelial...
Qier Wu,Olivier Taboureau,Karine Audouze
Qier Wu
Despite of their therapeutic effects, drug's exposure may have negative effects on human health such as adverse drug reaction (ADR) and side effects (SE). Adverse drug events (ADEs), that correspond to an event occurring during the drug tre...
The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites [0.03%]
镇痛药及其主要代谢产物对转录表达调控及多药耐药相关蛋白4(MRP4)的抑制作用
Renato J Scialis,Carolina I Ghanem,José E Manautou
Renato J Scialis
During the course of a toxic challenge, changes in gene expression can manifest such as induction of metabolizing enzymes as a compensatory detoxification response. We currently report that a single 400 mg/kg acetaminophen (APAP) dose to C5...