Using yeast two-hybrid system and molecular dynamics simulation to detect venom protein-protein interactions [0.03%]
利用酵母双杂交系统和分子动力学模拟检测毒液蛋白质间相互作用
Ying Jia,Paulina Kowalski,Ivan Lopez
Ying Jia
Proteins and peptides are major components of snake venom. Venom protein transcriptomes and proteomes of many snake species have been reported; however, snake venom complexity (i.e., the venom protein-protein interactions, PPIs) remains lar...
Toxicity of poly-dispersed single-walled carbon nanotubes on bone marrow derived Hematopoietic Stem and Progenitor Cells [0.03%]
聚分散型单壁碳纳米管对骨髓来源的造血干细胞和祖细胞的毒性作用
Md Babu Mia,Rajiv K Saxena
Md Babu Mia
This study has explored the effect of acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) on Hematopoietic Stem and Progenitor Cell (HSPCs) in mouse bone marrow. Administration of AF-SWCNTs induced a significant decline in the li...
DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha) [0.03%]
Withanone的DNA损伤可能是药用植物Withania somnifera(Ashwagandha)导致肝毒性的潜在原因
Shazia Siddiqui,Nabeel Ahmed,Mausumi Goswami et al.
Shazia Siddiqui et al.
Withania somnifera, commonly known as Ashwagandha, is a medicinal plant used for thousands of years for various remedies. Extracts of Ashwagandha contain more than 200 metabolites, with withanone (win) being one of the major ones responsibl...
The low doses of SWCNTs affect the expression of proliferation and apoptosis related genes in normal human astrocytes [0.03%]
低剂量碳纳米管对正常人星形胶质细胞增殖和凋亡相关基因表达的影响
Olha V Rudnytska,Olena O Khita,Dmytro O Minchenko et al.
Olha V Rudnytska et al.
The unique properties of single-walled carbon nanotubes (SWCNTs) make them viable candidates for versatile implementation in the biomedical devices. They are able to cross the blood-brain barrier, enter cells and accumulate in cell nuclei. ...
Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and chemistry-based read-across [0.03%]
小鼠局部淋巴结试验（LLNA）在皮肤致敏判读中的应用：剂量饱和效应、损伤信号与基于化学结构的判读策略
David W Roberts
David W Roberts
There is a large body of information on testing of chemicals for skin sensitization in the murine local lymph node assay (LLNA), in which potency is quantified by the EC3 value, derived from dose-response data. This information finds use in...
Bridging the gap between toxicity and carcinogenicity of mineral fibres by connecting the fibre crystal-chemical and physical parameters to the key characteristics of cancer [0.03%]
通过将矿物纤维的晶体化学和物理参数与癌症的关键特征联系起来，来弥合毒性和致癌性之间的差距
Alessandro F Gualtieri
Alessandro F Gualtieri
Airborne fibres and particularly asbestos represent hazards of great concern for human health because exposure to these peculiar particulates may cause malignancies such as lung cancer and mesothelioma. Currently, many researchers worldwide...
Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action underlying liver tumor development [0.03%]
小鼠短期和亚慢性暴露四氢呋喃后肝脏转录组分析以评估潜在的肝肿瘤发展模式机制
G A Chappell,M M Heintz,L C Haws
G A Chappell
1,4-Dioxane is a volatile organic compound with industrial and commercial applications as a solvent and in the manufacture of other chemicals. 1,4-Dioxane has been demonstrated to induce liver tumors in chronic rodent bioassays conducted at...
In vitro assays for characterization of distinct multiple catalytic activities of thyroid peroxidase using LC-MS/MS [0.03%]
利用LC-MS/MS表征甲状腺过氧化物酶不同催化活性的体外实验
Abhishek Tater,Aditi Gupta,Gopal Upadhyay et al.
Abhishek Tater et al.
A diverse set of environmental contaminants have raised a concern about their potential adverse effects on endocrine signaling. Robust and widely accepted battery of in vitro assays is available to assess the disruption of androgenic and es...
Thomas B Knudsen,Mathieu Vinken
Thomas B Knudsen
The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes [0.03%]
人诱导多能干细胞的应用可以筛选出电子烟等不燃烧烟草产品较卷烟而言更低的发育毒性潜力
Liam Simms,Kathryn Rudd,Jessica Palmer et al.
Liam Simms et al.
devTOX quickPredict (devTOX qP ) is a metabolomics biomarker-based assay that utilises human induced pluripotent stem (iPS) cells to screen for potential early stage embryonic developmental toxicity in vitro. Developmental toxicity potentia...