Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan [0.03%]
吉非替尼和厄洛替尼与氟西汀和/或洛沙坦等细胞色素P450抑制药物联用的临床前药物相互作用研究
Thu-Lan T Luong,Michael J McAnulty,David L Evers et al.
Thu-Lan T Luong et al.
Objective: To evaluate drug-drug interactions (DDIs) between gefitinib or erlotinib with fluoxetine, and/or losartan. Methods: Human po...
Junichi R Sakaki,Melissa M Melough,Cathy Z Yang et al.
Junichi R Sakaki et al.
Coffee brewed from capsule machines may contain estrogenic chemicals migrated from plastic, but the estrogenic activity of capsule coffee has not been evaluated. This study evaluated the estrogenic activity of capsule coffee using the VM7Lu...
In vitro prediction of clinical signs of respiratory toxicity in rats following inhalation exposure [0.03%]
预测吸入暴露后大鼠呼吸道毒性的临床症状的体外试验
E Da Silva,C Hickey,G Ellis et al.
E Da Silva et al.
To date there are no OECD validated alternative approaches to study toxicity following inhalation exposure to airborne chemicals. The available OECD test guidelines for acute inhalation toxicity aim to estimate a value of the lethal air con...
Carcinogenicity of fibrous glaucophane: How should we fill the data gaps? [0.03%]
纤维石绵的致癌性：如何填补数据空白？
Ann G Wylie,Andrey A Korchevskiy
Ann G Wylie
•The modeled glaucophane mesothelioma potency is 0.0085 % vs. 0.5 % for riebeckite.•Lung cancer potency of glaucophane is 0.36 % vs. 4.82 % for Australian crocidolite.•The fibrosity index of glaucophane (0.77) is typical for non-asbestif...
Dietary administration of β-ionone epoxide to Sprague-Dawley rats for 90 days [0.03%]
口服β-离子ONE环氧化物喂养SD大鼠90天
Vivian Lu,Maria Bastaki,Anne Marie Api et al.
Vivian Lu et al.
In a 90-day GLP-compliant study groups of Sprague-Dawley rats (10/sex/group) were fed diets containing β-ionone epoxide, a fragrance material and a flavoring substance, at dietary concentrations providing target intakes of 0, 20, 40 and 80...
Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives [0.03%]
内分泌干扰物在尿道下裂发病机制中的作用；发育和毒理学观点
Deidre M Mattiske,Andrew J Pask
Deidre M Mattiske
Hypospadias is a defect in penile urethral closure that occurs in approximately 1/150 live male births in developed nations, making it one of the most common congenital abnormalities worldwide. Alarmingly, the frequency of hypospadias has i...
Utilizing systems biology to reveal cellular responses to peroxisome proliferator-activated receptor γ ligand exposure [0.03%]
利用系统生物学揭示过氧化物酶体增殖激活受体γ配体暴露的细胞反应
Vanessa Cheng,Aalekhya Reddam,Anil Bhatia et al.
Vanessa Cheng et al.
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that, upon activation by ligands, heterodimerizes with retinoid X receptor (RXR), binds to PPAR response elements (PPREs), and activates transcription of downstrea...
Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR [0.03%]
人源和猪源原代肝细胞经典型AhR、CAR和PXR激活剂诱导后显示相似的细胞色素P450表达模式
Sabine Gerbal-Chaloin,Philippe Briolotti,Martine Daujat-Chavanieu et al.
Sabine Gerbal-Chaloin et al.
The hepatic cytochrome p450's (CYP) are of major importance for the metabolism of xenobiotics and knowledge about their regulation is crucial. This knowledge often originates from cell models; primary human hepatocytes (PHH) being the gold ...
Wheatgrass inhibits the lipopolysaccharide-stimulated inflammatory effect in RAW 264.7 macrophages [0.03%]
小麦草抑制LPS刺激的RAW 264.7巨噬细胞的炎症效应
Somesh Banerjee,Parul Katiyar,Vijay Kumar et al.
Somesh Banerjee et al.
Inflammation is a multifaceted set of cellular communications generated against foreign infection, toxic influence or autoimmune injury. The present study investigates the anti-inflammatory effect of wheatgrass extract against the harmful i...
Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke [0.03%]
电子烟气溶胶或卷烟烟雾反复暴露后对人体三维气管上皮的多靶点分析
Lukasz Czekala,Roman Wieczorek,Liam Simms et al.
Lukasz Czekala et al.
Smoking is a cause of serious diseases in smokers including chronic respiratory diseases. This study aimed to evaluate the tobacco harm reduction (THR) potential of an electronic vapor product (EVP, myblu™) compared to a Kentucky Reference...