Venom peptides - A comprehensive translational perspective in pain management [0.03%]
毒液肽类 - 在疼痛管理中一个全面的转化展望
Vidya V,Raghu Ram Achar,Himathi M U et al.
Vidya V et al.
Venom peptides have been evolving complex therapeutic interventions that potently and selectively modulate a range of targets such as ion channels, receptors, and signaling pathways of physiological processes making it potential therapeutic...
Three photoinitiators induce breast tumor growth in mouse xenografts with MCF-7 breast cancer cells [0.03%]
三种光引发剂促进MCF-7乳腺癌细胞小鼠移植瘤的生长
Yoichi Kawasaki,Toshiaki Sendo
Yoichi Kawasaki
Photoinitiators are utilized in the production of a wide range of commonly used products. However, some photoinitiators exert toxic effects. We previously demonstrated the endocrine-disrupting effects of photoinitiators in vitro. The presen...
Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes [0.03%]
用于快速筛查疾病的人类原代细胞模型在下一代产品与可燃卷烟比较中的应用研究论文
Liam Simms,Elizabeth Mason,Ellen L Berg et al.
Liam Simms et al.
A growing number of public health bodies, regulators and governments around the world consider electronic vapor products a lower risk alternative to conventional cigarettes. Of critical importance are rapid new approach methodologies to ena...
Chlorpyrifos and Δ9 Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity [0.03%]
氯吡rifos和Δ9四氢大麻酚对与内源性 cannabinoid系统相关的参数和肥胖风险因素的影响
Marilyn H Silva
Marilyn H Silva
Marilyn Silva. Retired from a career in toxicology and risk assessment. Increased childhood and adult obesity are associated with chlorpyrifos (CPF), an organophosphate pesticide. Cannabis (Δ9Tetrahydrocannabinol: Δ9THC) use has increased...
Reproducibility and robustness of high-throughput S1500+ transcriptomics on primary rat hepatocytes for chemical-induced hepatotoxicity assessment [0.03%]
基于原代大鼠肝细胞的高通量S1500+转录组学在化学性肝毒性评估中的重复性和稳健性研究
Fan Lee,Imran Shah,Yun Ting Soong et al.
Fan Lee et al.
Cell-based in vitro models coupled with high-throughput transcriptomics (HTTr) are increasingly utilized as alternative methods to animal-based toxicity testing. Here, using a panel of 14 chemicals with different risks of human drug-induced...
Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database [0.03%]
采用比较毒物基因组学数据库预测Juul电子烟气溶胶化学物质诱导的分子机制、信号通路及健康影响
Cynthia J Grondin,Allan Peter Davis,Jolene A Wiegers et al.
Cynthia J Grondin et al.
There is a critical need to understand the health risks associated with vaping e-cigarettes, which has reached epidemic levels among teens. Juul is currently the most popular type of e-cigarette on the market. Using the Comparative Toxicoge...
Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development [0.03%]
雄性大鼠生殖道异常拟预测不良结局通路网络的发展，并具体考虑发育过程中雄激素敏感窗口的特征
Christine M Palermo,Jennifer E Foreman,Daniele S Wikoff et al.
Christine M Palermo et al.
Structured approaches like the adverse outcome pathway (AOP) framework offer great potential for depicting complex toxicological processes in a manner that can facilitate informed integration of mechanistic information in regulatory decisio...
Physical and psychological stress along with candle fumes induced-cardiopulmonary injury mimicking restaurant kitchen workers [0.03%]
物理和心理压力以及烛烟引起的肺心损伤类似餐厅厨房工作者
Victor Raj Mohan Chandrasekaran,Srinivasan Periasamy,Se-Ping Chien et al.
Victor Raj Mohan Chandrasekaran et al.
Restaurant kitchens are work areas where involve strict and hierarchal environments that promote opportunity for bullying and workplace aggression and violence. These physical and psychological stress and fumes ultimately trigger severe occ...
Predicting the potential toxicity of 26 components in Cassiae semen using in silico and in vitro approaches [0.03%]
采用计算和体外实验预测决明种子里26种成分的潜在毒性
Jinlan Yang,Shuo Wang,Tao Zhang et al.
Jinlan Yang et al.
Cassiae semen are dried and ripe seeds of Cassia obtusifolia L. or Cassia tora L. (Fabaceae) and have been made into roasted tea or used as a traditional medicine in Asian countries. However, it was reported to result in liver and renal tox...
An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function [0.03%]
导致肺功能下降的肺表面活性剂功能抑制的不良结果途径
Emilie Da Silva,Ulla Vogel,Karin S Hougaard et al.
Emilie Da Silva et al.
Inhaled substances, such as consumer products, chemicals at the workplace, and nanoparticles, can affect the lung function in several ways. In this paper, we explore the adverse outcome pathway (AOP) that starts when inhaled substances that...