Tomohiro Nabekura,Shinya Ishikawa,Makoto Tanase et al.
Tomohiro Nabekura et al.
Selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and noradrenergic and specific serotonergic antidepressants (NaSSAs) are broadly used for the treatment of depression. Depression is o...
Assessment of the effects of organic vs. inorganic arsenic and mercury in Caenorhabditis elegans [0.03%]
有机砷和汞与无机砷和汞对秀丽隐杆线虫的影响评估
Jessica Camacho,Aline de Conti,Igor P Pogribny et al.
Jessica Camacho et al.
Exposures to mercury and arsenic are known to pose significant threats to human health. Effects specific to organic vs. inorganic forms of these toxic elements are less understood however, especially for organic dimethylarsinic acid (DMA), ...
The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function [0.03%]
多环芳香烃化合物(PACs)对哺乳动物卵巢功能的影响
Genevieve A Perono,James J Petrik,Philippe J Thomas et al.
Genevieve A Perono et al.
Polycyclic aromatic compounds (PACs) are a broad class of contaminants ubiquitously present in the environment due to natural and anthropogenic activities. With increasing industrialization and reliance on petroleum worldwide, PACs are incr...
AOP Key Event Relationship report: Linking decreased retinoic acid levels with disrupted meiosis in developing oocytes [0.03%]
卵母细胞发育过程中视黄酸水平降低与减数分裂紊乱之间的关系报告
Monica Kam Draskau,Anne-Sofie Ravn Ballegaard,Louise Ramhøj et al.
Monica Kam Draskau et al.
The Adverse Outcome Pathway (AOP) concept is an emerging tool in regulatory toxicology that uses simplified descriptions to show cause-effect relationships between stressors and toxicity outcomes in intact organisms. The AOP structure is a ...
Subchronic toxicity and genotoxicity studies of Hericium erinaceus β-glucan extract preparation [0.03%]
刺鲍菇β-葡聚糖提取物的亚慢性毒性和遗传毒性研究
S N Chen,C S Chang,M F Yang et al.
S N Chen et al.
The medicinal effects of Hericium erinaceus have been long documented in scientific studies of Eastern traditional medicine. It is widely consumed, because of its nutritional qualities and perceived health benefits. Also, it is rich in β-g...
Assessment of nicotine delivery and uptake in users of various tobacco/nicotine products [0.03%]
评估不同烟草/尼古丁产品的尼古丁输送和吸收情况
Gerhard Scherer,Janina Mütze,Nikola Pluym et al.
Gerhard Scherer et al.
Today various tobacco and nicotine products are available, many of them can be regarded as potentially risk-reduced products when compared to the most frequently used product, combustible cigarettes (CCs). A commonality of these products is...
Toxic effects of smokeless tobacco on female reproductive health: A review [0.03%]
无烟烟草对女性生殖健康的危害：一篇综述
C Laldinsangi
C Laldinsangi
The habitual consumption of tobacco in its various form is widespread and a serious public health issue globally. In particular, the use of smokeless tobacco has increased substantially due to its easy availability and misconception that it...
Development of an adverse outcome pathway for intrahepatic cholestasis of pregnancy [0.03%]
妊娠期肝内胆汁淤积症的不利结果途径的发展
Jennifer Waspe,Anna Beronius
Jennifer Waspe
Adverse Outcome Pathways (AOPs) are a research synthesis tool, used primarily by toxicologists for numerous applications including: hypothesis generation, data integration, biomarker determination, and identification of gaps in current know...
Use of computational toxicology tools to predict in vivo endpoints associated with Mode of Action and the endocannabinoid system: A case study with chlorpyrifos, chlorpyrifos-oxon and Δ9Tetrahydrocannabinol [0.03%]
用于预测与作用模式和内源大麻素系统相关的体内终点的计算毒理学工具的应用：氯吡rif、氯吡rif-氧
Marilyn Silva,Ryan Kin-Hin Kwok
Marilyn Silva
Currently, there is a lack of knowledge about the effects of co-exposures of cannabis, contaminated with pesticides like chlorpyrifos (CPF) and the toxic metabolite CPF-oxon (CPFO). CPF/CPFO residues, and Δ9Tetrahydrocannabinol (Δ9THC), t...
Letter to the Editor: Comments on the paper of Wylie and Korchevskiy - Carcinogenicity of fibrous glaucophane: How should we fill the data gaps? [0.03%]
致编辑的信：关于Wylie和Korchevskiy的文章“石棉矿的致癌性：我们应该如何填补数据空白？”的评论
Alessandro F Gualtieri,Dario Di Giuseppe
Alessandro F Gualtieri
Assessing the human health risk of mineral fibres is an intricate task. In the recent article by Wylie and Korchevskiy (2021) - Carcinogenicity of fibrous glaucophane: how to fill data gaps? (Curr. Res. Toxicol. Vol. 2, pp. 202-203), the au...