The effect of ethanol and nicotine on ER stress in human placental villous explants [0.03%]
乙醇和尼古丁对人胎盘绒毛外植体内内质网应激的影响
M Huovinen,F Ietta,J K Repo et al.
M Huovinen et al.
Pregnant mothers continue smoking and drinking during pregnancy. To clarify the mechanisms of nicotine and ethanol toxicity during development, we have examined their effects on endoplasmic reticulum (ER) stress in human first trimester and...
Aflatoxin B1 targeted gene expression profiles in human placental primary trophoblast cells [0.03%]
黄曲霉毒素B1靶向人胎盘原代滋养细胞的基因表达谱分析
Rami El-Dairi,Jaana Rysä,Markus Storvik et al.
Rami El-Dairi et al.
Aflatoxin B1 (AFB1) is a mycotoxin produced by Aspergillus flavus and A. parasiticus. A high exposure (40 nM and 1 µM AFB1 for 72 h) was used to study mechanistic effects of AFB1 on gene expression patterns in human primary trophoblast cel...
Plasma level of antimony correlates with pulmonary arterial hypertension severity [0.03%]
锑的血浆水平与肺动脉高压严重程度相关
Karim El-Kersh,C Danielle Hopkins,Xiaoyong Wu et al.
Karim El-Kersh et al.
It is unknown if environmental antimony exposure influences pulmonary arterial hypertension (PAH) and right ventricular function. We performed a pilot study to evaluate antimony levels in 20 PAH patients and 10 controls. Also, we explored t...
Current research in pathophysiology of opioid-induced respiratory depression, neonatal opioid withdrawal syndrome, and neonatal antidepressant exposure syndrome [0.03%]
阿片所致呼吸抑制、新生儿戒断综合征及抗抑郁药暴露的发病机制研究进展
Brian A Baldo
Brian A Baldo
Respiratory depression (RD) is the primary cause of death due to opioids. Opioids bind to mu (µ)-opioid receptors (MORs) encoded by the MOR gene Oprm1, widely expressed in the central and peripheral nervous systems including centers that m...
Halogenated bisphenol a analogues induce PPARγ-independent toxicity within human hepatocellular carcinoma cells [0.03%]
卤代双酚A类似物诱导人类肝癌细胞PPARγ非依赖性毒性
Vanessa Cheng,David C Volz
Vanessa Cheng
Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) - both halogenated bisphenol (BPA) analogues - are suspected ligands of peroxisome proliferator-activated receptor gamma (PPARγ). While previous studies have shown that TBBPA...
The influence of maternal weight and alcohol exposure on infant physical characteristics and neurodevelopmental outcomes [0.03%]
母亲体重和酒精暴露对婴儿体格特征和神经发育结局的影响
Julie M Hasken,Linda S Adair,Stephanie L Martin et al.
Julie M Hasken et al.
Background: Mothers of children with fetal alcohol spectrum disorders tend to have lower weight compared to other mothers. Yet how alcohol and maternal weight may predispose infants to poorer physical growth and neurodeve...
The utility of alternative models in particulate matter air pollution toxicology [0.03%]
替代模型在颗粒物空气污染毒理学中的应用价值
Jacob Smoot,Stephanie Padilla,Aimen K Farraj
Jacob Smoot
Exposure to particulate matter (PM) air pollution increases risk of adverse human health effects. As more attention is brought to bear on the problem of PM, traditional mammalian in vivo models struggle to keep up with the risk assessment c...
A review on the mitochondrial toxicity of "ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) [0.03%]
有关摇头丸（3,4-亚甲基二氧基甲基苯丙胺，MDMA）线粒体毒性的综述研究
João Paulo Capela,Félix Dias Carvalho
João Paulo Capela
3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a drug of abuse used by millions worldwide. MDMA human abuse and dependence is well described, but addictive properties are not always consistent among studies. This amphetamine is a ...
Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity [0.03%]
多能干细胞检测：预测发育毒性的模式与应用
Aldert H Piersma,Nancy C Baker,George P Daston et al.
Aldert H Piersma et al.
This manuscript provides a review focused on embryonic stem cell-based models and their place within the landscape of alternative developmental toxicity assays. Against the background of the principles of developmental toxicology, the wide ...
Triclosan-induced neuroinflammation develops caspase-independent and TNF-α signaling pathway associated necroptosis in Neuro-2a cells [0.03%]
三氯生诱导的神经炎症通过caspase非依赖性和TNF-α信号通路相关坏死性凋亡在Neuro-2a细胞中发展
Parul Katiyar,Somesh Banerjee,Sandip Nathani et al.
Parul Katiyar et al.
Triclosan (TCS) is widely used in cosmetics and healthcare industry as a broad-spectrum antibacterial agent. The lipophilic property and persistent nature of TCS has led to severe health issues. In the present study, we have evaluated the n...