Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib [0.03%]
CSF1受体特异性拮抗剂Sotuletinib对大鼠肝脏酶延迟清除的影响研究
François Pognan,Chiara Buono,Philippe Couttet et al.
François Pognan et al.
Sotuletinib (BLZ945), a CSF1-R specific kinase inhibitor developed for the treatment of Amyotrophic Lateral Sclerosis, induced liver enzyme elevation in absence of hepatocellular lesions in preclinical rat and monkey studies. The monocytic ...
Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays [0.03%]
正交测定法对高通量筛选数据的确认及FXR-外来化合物相互作用的新机制研究
Jon Hamm,Debabrata Mahapatra,Megan M Knuth et al.
Jon Hamm et al.
Toxicology in the 21st Century (Tox21) is a federal collaboration employing a high-throughput robotic screening system to test 10,000 environmental chemicals. One of the primary goals of the program is prioritizing toxicity evaluations thro...
Marika Mannerström,Marketa Dvorakova,Lada Svobodova et al.
Marika Mannerström et al.
Indoor air is typically a mixture of many chemicals at low concentrations without any adverse health effects alone, but in mixtures they may cause toxicity and risks to human health. The aim of this study was by using new approach methods t...
Editorial: New mechanistic insight into perinatal origins of reproductive disorders caused by chemical exposures [0.03%]
编辑部：化学暴露所致围产期生殖障碍新机制的见解
Terje Svingen
Terje Svingen
Introducing a Special Issue on mechanism of reproductive disorders in mammals originating from exposure to environmental chemicals during perinatal life. ...
Interaction between mono-(2-ethylhexyl) phthalate and retinoic acid alters Sertoli cell development during fetal mouse testis cord morphogenesis [0.03%]
单(2-乙基己基)邻苯二甲酸酯与视黄酸的相互作用会改变小鼠睾丸生精细胞 cords 发育过程中支持细胞的发育
Maha A Alhasnani,Skylar Loeb,Susan J Hall et al.
Maha A Alhasnani et al.
Phthalic acid esters (phthalates) are a class of industrial chemicals that cause developmental and reproductive toxicity, but there are significant gaps in knowledge of phthalate toxicity mechanisms. There is evidence that phthalates disrup...
Lactobacilli metabolites restore E-cadherin and suppress MMP9 in cervical cancer cells [0.03%]
乳酸菌代谢产物恢复宫颈癌细胞中的E-钙黏着蛋白并抑制MMP9
Krupali Pawar,Clara Aranha
Krupali Pawar
Cervical cancer is leading cause of cancer death in females worldwide. Vaginal lactobacilli colonizing cervical area are known to play an important role in maintaining cervical physiological conditions to ward away vaginal infections includ...
Genome-wide expression screening in the cardiac embryonic stem cell test shows additional differentiation routes that are regulated by morpholines and piperidines [0.03%]
心脏胚胎干细胞试验中的基因表达筛选显示由morpholines和piperidines调节的额外分化途径
R H Mennen,N Hallmark,M Pallardy et al.
R H Mennen et al.
The cardiac embryonic stem cell test (ESTc) is a well-studied non-animal alternative test method based on cardiac cell differentiation inhibition as a measure for developmental toxicity of tested chemicals. In the ESTc, a heterogenic cell p...
AOP key event relationship report: Linking androgen receptor antagonism with nipple retention [0.03%]
AOP关键事件关系报告：连接雄激素受体拮抗作用与乳头滞留现象的关系
Emilie Bak Pedersen,Sofie Christiansen,Terje Svingen
Emilie Bak Pedersen
In rat developmental and reproductive toxicity studies, nipple/areola retention (NR) in male offspring is a biomarker for reduced androgen signaling during development. This is because nipples normally regress in male rats in response to an...
Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans [0.03%]
温和的五氯苯酚介导的线粒体解偶联会耗尽ATP，但不会导致秀丽隐杆线虫中的氧化型细胞还原态或多巴胺能神经退行性病变
Zachary R Markovich,Jessica H Hartman,Ian T Ryde et al.
Zachary R Markovich et al.
Aims: Mitochondrial dysfunction is implicated in several diseases, including neurological disorders such as Parkinson's disease. However, there is uncertainty about which of the many mechanisms by which mitochondrial func...
Oxidative damage in metal fragment-embedded Sprague-Dawley rat gastrocnemius muscle [0.03%]
金属片嵌入的大鼠腓肠肌中的氧化损伤
John F Kalinich,Vernieda B Vergara,Jessica F Hoffman
John F Kalinich
Injuries suffered in armed conflicts often result in wounds with embedded metal fragments. Standard surgical guidance has been to leave fragments in place except under certain circumstances; meaning that individuals may carry these retained...