YanLing Yang,Huan Liang,Yi Liu et al.
YanLing Yang et al.
Oral nicotine products are a category of novel tobacco products that deliver nicotine through oral consumption. With increasing tobacco control measures worldwide and growing public health awareness, its safety risk has gained attention. Ho...
Elucidating the toxicity of the plasticizer DPhP: Evidence of neurotoxicity and developmental impairment from in vitro to in vivo models [0.03%]
塑化剂DPhP的毒理学研究：从体外到体内模型的神经毒性及发育障碍证据
Lipeng Zhu,Zhipeng Xie,Xinyang Zhang et al.
Lipeng Zhu et al.
As an emerging substitute for conventional phthalates, diphenyl phthalate (DPhP) raises growing environmental health concerns, yet its systemic toxicity profile remains poorly characterized. We used human umbilical vein endothelial cell (HU...
Do the habits and preferences of heated-tobacco-product users affect the emission characteristics of nicotine, PG, and VG? [0.03%]
加热烟草产品用户的习惯和偏好会影响尼古丁、PG和VG的排放特性吗？
Dong-Han Kim,Dae-Hyeon Kim,Youn-Suk Son
Dong-Han Kim
In this study, the delivery of three substances (nicotine, propylene glycol (PG), and vegetable glycerin (VG)) in vapor generated by HTPs was evaluated based on the habits and preferences of users. To achieve this, the following five key ch...
Exposure to calcium stearyl lactylate induces hepatointestinal toxicity and gut microbiota dysbiosis in mice [0.03%]
钙硬脂酰乳酸钠致小鼠肝肠毒性及肠道微生态失衡
Chunjing Qiu,Chenxu Guo,Xia Xue et al.
Chunjing Qiu et al.
Calcium stearyl lactylate (CSL) is a widely used food emulsifier, particularly in pasta products. In this study, we investigated the potential toxicological effects of CSL exposure on organ health and gut microbiota in mice. Over a 12-week ...
Direct exposure to vinclozolin induces sex-dependent mitochondrial dysfunction in mouse liver [0.03%]
直接暴露于萎凋灵诱导小鼠肝脏性别依赖性线粒体功能障碍
Hwayeon Lim,Jisun Choi,Joo Young Huh et al.
Hwayeon Lim et al.
Vinclozolin is a dicarboximide anti-androgenic fungicide that has endocrine-disrupting impact on mammals. Endocrine disruptors are reported to impair mitochondrial function and reduce adenosine triphosphate (ATP) production. Moreover, incre...
Loss of KLF15 expression characterizes proximal tubule injury in cisplatin-induced acute kidney injury: A multi-omics study [0.03%]
KLF15表达的丧失是顺铂诱导急性肾损伤中近端小管受损的特征：一项多组学研究
Lei Chen,Shiying Xie,Heqing Yang et al.
Lei Chen et al.
Nephrotoxicity is a common side effect of cisplatin (CSP), a widely-used anti-tumor chemotherapy drug. Acute kidney injury (AKI) induced by it is characterized by inflammation, apoptosis, and metabolic reprogramming in proximal tubule (PT) ...
Effects of the combination of brefeldin A and tunicamycin on endoplasmic reticulum stress and apoptosis in human normal hepatocytes [0.03%]
曲安西林和苯乙醇胺A联合处理人正常肝细胞的内质网应激及凋亡效应研究
Ying Yang,Minfei Hou,Minghong Li et al.
Ying Yang et al.
Background: Due to its ability to inhibit the growth of hepatoma cells, brefeldin A (BFA) has been considered a promising drug candidate for liver cancer. However, there is limited research on its safety profile and poten...
Aromatic aldehydes formed during heating of cinnamon-flavored e-liquids drive pro-inflammatory responses in human aortic smooth muscle cells [0.03%]
肉桂调味电子烟液加热过程中形成的芳香醛可驱动人主动脉平滑肌细胞的促炎症反应
Mariam Bitar,Jérémie Pourchez,Mohamad Sleiman et al.
Mariam Bitar et al.
Flavor additives can contribute to the biological effects of electronic cigarette (e-cigarette) aerosols, yet the mechanisms underlying flavor-related vascular toxicity remain poorly understood. We previously showed that exposure of human a...
Polylactic acid microplastics as metabolic disruptors: Linking gut dysbiosis to systemic toxicity by disrupting microbiota-host co-metabolism [0.03%]
聚乳酸微塑料作为代谢干扰物：通过破坏微生物群-宿主共代谢将肠道菌群失调与系统毒性联系起来
Yumiao Li,Ziyi Zhou,Hui Xu et al.
Yumiao Li et al.
The increasing application of polylactic acid (PLA) in consumer products leads to the widespread environmental distribution of its micro- and nano-plastics (PLA-MNPs). These particles pose potential health risks following environmental expo...
Protective role of calcitriol in PM2.5-induced apoptosis and inflammation in bronchial epithelial cells in vitro via vitamin D receptor-mediated Nrf2 signaling [0.03%]
维生素D受体介导的Nrf2信号通路在1,25-二羟基维生素D三级醇对PM2.5诱导的人支气管上皮细胞凋亡及炎症中的保护作用
Mutita Pluempreecha,Anyamanee Chatsirisupachai,Tanyapohn Soingam et al.
Mutita Pluempreecha et al.
PM2.5 contributes to lung injury by inducing oxidative stress, inflammatory responses, and apoptosis. Calcitriol exerts a protective role against lung injury by regulating the vitamin D receptor (VDR) and Nrf2 signaling pathways, mitigating...