Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions [0.03%]
聚乙烯微塑料在DSS诱导结肠炎动物模型中通过损害肠道上皮细胞连接结构而加重炎症反应
Minkyoung Sung,Yeon-Ji Lee,Soo-Eun Sung et al.
Minkyoung Sung et al.
Microplastics are pollutants that occur in various environments and habitats. Inflammatory bowel disease (IBD) is a chronic inflammatory disease accompanied with diarrhea, and the number of patients has increased worldwide. In this study, m...
Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone [0.03%]
代谢组学特征分析揭示颗粒物和臭氧联合暴露引起的整体代谢紊乱
Yue Ge,Maliha S Nash,Aimen K Farraj
Yue Ge
Air pollution exposure, especially particulate matter (PM) and ozone (O3), poses significant health risks, but the systemic metabolic consequences of combined exposures to PM and O3, remain poorly understood. This study investigated systemi...
Laying the groundwork: Exploring pesticide exposure and genetic factors in south-eastern Brazilian farmers [0.03%]
农药暴露与遗传因素在巴西东南部农民中的影响研究
Débora Dummer Meira,Victor Nogueira Da Gama Kohls,Matheus Correia Casotti et al.
Débora Dummer Meira et al.
Brazil is the world leader in pesticide consumption, and its indiscriminate use puts farmers' health at risk. The CYP2C9 gene encodes the CYP2C9 enzyme, which metabolizes several endogenous substrates and specific xenobiotics, especially pe...
Efficacy of a hydrogen-oxygen generator in treating cigarette smoke-induced chronic obstructive pulmonary disease in rats [0.03%]
富氢气体对烟雾诱导慢性阻塞性肺病大鼠的治疗作用研究
Wan-Ting Huang,Tzong-Jih Cheng,Lin-Hsiang Huang et al.
Wan-Ting Huang et al.
Current treatments for chronic obstructive pulmonary disease (COPD), a common respiratory condition, include oxygen therapy and steroids for temporary relief. In this study, we established a rat model of cigarette smoke (CS)-induced COPD an...
Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery [0.03%]
微生理系统在应对阿片类药物危机中的应用——急性阿片类药物流行和恢复的新型多器官模型
Aakash Patel,Suruchi Poddar,Daniel Nierenberg et al.
Aakash Patel et al.
Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a public health crisis of overdose related deaths. Naloxone is the curren...
RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice [0.03%]
RhoA/ROCK2信号通路介导的锰致紧密连接蛋白改变导致小鼠认知障碍的研究
Yan Ma,Honggang Chen,Yuxin Jiang et al.
Yan Ma et al.
Elevated manganese (Mn) exposure has been implicated in a broad spectrum of neurological disorders, including motor dysfunction and cognitive deficits. Previous studies have demonstrated that Mn induces neurotoxicity by disrupting the integ...
The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity [0.03%]
肠道微生物群和烟酸/烟酰胺途径在罗特诺毒素诱导的神经毒性中的作用
Yan Sai,Wei Ge,Li Zhong et al.
Yan Sai et al.
Rotenone is a natural compound from plants. It is widely used in pesticides because of highly toxic to insects and fish. However, lots of research has reported that rotenone has neurotoxic effects in humans. It is confirmed there is a corre...
A simple, reliable and easily generalizable cell-based assay for screening potential drugs that inhibit lipid accumulation [0.03%]
一种简单可靠的细胞水平抑制脂肪蓄积药物筛选体系
Weili Yang,Qiuyue Pan,Qi Li et al.
Weili Yang et al.
Ectopic lipid deposition in the hepatocyte plays an important role in the development of nonalcoholic fatty liver disease (NAFLD), which has become one of the most common causes of chronic liver disease worldwide yet no approved drugs are c...
L-3-n-butylphthalide alleviates intermittent alcohol exposure-induced hypothalamic cell apoptosis via inhibiting the IRE1α-ASK1-JNK pathway in adolescent rats [0.03%]
L-3-丁基苯酞通过抑制IRE1α-ASK1-JNK信号通路缓解间歇性酒精暴露致青春期大鼠下丘脑细胞凋亡
Shanyong Yi,Lai Wei,Bin Zhao et al.
Shanyong Yi et al.
Exposure to alcohol can induce different degrees of damage to various tissues and organs, and brain is the most vulnerable part affected by alcohol. However, there is no detailed report on whether intermittent alcohol exposure can result in...
Benedikt Bauer,Helena Rossi,Henning Hintzsche
Benedikt Bauer
The anthraquinone dye Alizarin Red S (ARS) is used for marking live animals, specifically as a tool for monitoring the stock of the endangered European eel by marking caught fish with ARS before releasing the eels back into the wild. As ARS...