Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system [0.03%]
腺相关病毒技术递送基因编码货物至非人灵长类神经系统载货的研究进展
Lillian J Campos,Cynthia M Arokiaraj,Miguel R Chuapoco et al.
Lillian J Campos et al.
Modern neuroscience approaches including optogenetics, calcium imaging, and other genetic manipulations have facilitated our ability to dissect specific circuits in rodent models to study their role in neurological disease. These approaches...
Stimulus contrast modulates burst activity in the lateral geniculate nucleus [0.03%]
刺激对比度调制外侧膝状体的爆发活动
Alyssa N Sanchez,Henry J Alitto,Daniel L Rathbun et al.
Alyssa N Sanchez et al.
Burst activity is a ubiquitous feature of thalamic neurons and is well documented for visual neurons in the lateral geniculate nucleus (LGN). Although bursts are often associated with states of drowsiness, they are also known to convey visu...
Alterations of fractional anisotropy throughout cortico-basal ganglia gray matter in a macaque model of Huntington's Disease [0.03%]
亨廷顿舞蹈病猕猴模型中皮层-纹状体灰质各向异性的改变
Alison R Weiss,William A Liguore,Kristin Brandon et al.
Alison R Weiss et al.
We recently generated a nonhuman primate (NHP) model of the neurodegenerative disorder Huntington's disease (HD) using adeno-associated viral vectors to express a fragment of mutant HTT protein (mHTT) throughout the cortico-basal ganglia ci...
Impact of emotional valence on mismatch negativity in the course of cortical face processing [0.03%]
情感估值对皮层面部处理过程中Mismatch Negativity的影响
Maximilian Kaffes,Lea Rabe,Armin Rudolph et al.
Maximilian Kaffes et al.
Various aspects of cortical face processing have been studied by assessing event related potentials (ERP). It has been described in the literature that mismatch negativity (MMN), a well-studied ERP, is not only modulated by sensory features...
Neural substrates of perception in the vestibular thalamus during natural self-motion: A review [0.03%]
前庭丘脑在自然自我运动中的感知神经基底：综述
Kathleen E Cullen,Maurice J Chacron
Kathleen E Cullen
Accumulating evidence across multiple sensory modalities suggests that the thalamus does not simply relay information from the periphery to the cortex. Here we review recent findings showing that vestibular neurons within the ventral poster...
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22 [0.03%]
针对CMT1A模型鼠中过表达的PMP22，端末补体系统的整体抑制减少了神经炎症但不能改善运动功能
Iliana Michailidou,Jeroen Vreijling,Matthijs Rumpf et al.
Iliana Michailidou et al.
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most prevalent hereditary demyelinating neuropathy. This autosomal, dominantly inherited disease is caused by a duplication on chromosome 17p which includes the peripheral myelin protein 22...
Tatsuya Daikoku,Masato Yumoto
Tatsuya Daikoku
Statistical learning (SL) is an innate mechanism by which the brain automatically encodes the n-th order transition probability (TP) of a sequence and grasps the uncertainty of the TP distribution. Through SL, the brain predicts a subsequen...
Persistent olfactory learning deficits during and post-COVID-19 infection [0.03%]
新冠感染期间和之后持续存在的嗅觉学习缺陷
Rajdeep Bhowmik,Meenakshi Pardasani,Sarang Mahajan et al.
Rajdeep Bhowmik et al.
Quantifying olfactory impairments can facilitate early detection of Coronavirus disease 2019 (COVID-19). Despite being a debated topic, many reports provide evidence for the neurotropism of SARS-CoV-2. However, a sensitive, specific, and ac...
Layer-specific correlates of detected and undetected auditory targets during attention [0.03%]
注意状态下被察觉和未被察觉的听觉目标的层状相关因素
Miriam Heynckes,Agustin Lage-Castellanos,Peter De Weerd et al.
Miriam Heynckes et al.
In everyday life, the processing of acoustic information allows us to react to subtle changes in the auditory scene. Yet even when closely attending to sounds in the context of a task, we occasionally miss task-relevant features. The neural...
Rb deficiency, neuronal survival and neurodegeneration: In search of the perfect mouse model [0.03%]
缺钾钳(Rbbp9)基因敲除小鼠模型与神经元的生存和凋亡
Saad Omais,Yara E El Atie,Noël Ghanem
Saad Omais
Three decades following the introduction of the first Rb knockout (KO) mouse model, the role of this critical protein in regulating brain development during embryogenesis and beyond remains a major scientific interest. Rb is a tumor suppres...