Protocol for a Wnt reporter assay to measure its activity in human neural stem cells derived from induced pluripotent stem cells [0.03%]
测量人诱导多能干细胞来源神经干细胞中Wnt活性的报告基因实验方案
Cristine Marie Yde Ohki,Natalie Monet Walter,Michelle Rickli et al.
Cristine Marie Yde Ohki et al.
The canonical Wnt signaling is an essential pathway that regulates cellular proliferation, maturation, and differentiation during neurodevelopment and maintenance of adult tissue homeostasis. This pathway has been implicated with the pathop...
Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome [0.03%]
progranulin是Fragile X综合征小鼠模型中FMRP的靶标并影响大睾丸症但不影响行为
Benjamin Life,Luis E B Bettio,Ilse Gantois et al.
Benjamin Life et al.
A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease. Specifically, increased progranulin expression in the prefrontal cor...
Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke [0.03%]
急性卒中期间猴脑二级躯体感觉皮层(S2)功能连接改变的纵向评估
Chun-Xia Li,Frank Tong,Doty Kempf et al.
Chun-Xia Li et al.
Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In...
Are there disciplinary boundaries in the comparative study of primate cognition? [0.03%]
灵长类认知的比较研究中有学科界限吗？
Héctor M Manrique,Juan J Canales
Héctor M Manrique
A view continues to gain momentum that regards investigation of the cognition of great apes in captive settings as affording us a model for human cognitive evolution. Researchers from disciplines such as comparative psychology, anthropology...
Maresin-2 inhibits inflammatory and neuropathic trigeminal pain and reduces neuronal activation in the trigeminal ganglion [0.03%]
maresin-2抑制三叉神经炎症性和神经病理性疼痛并减少三叉神经节神经元活化
Raphael Vieira Lopes,Darciane Favero Baggio,Camila Rodrigues Ferraz et al.
Raphael Vieira Lopes et al.
Pain is a common symptom associated with disorders involving the orofacial structures. Most acute orofacial painful conditions are easily recognized, but the pharmacological treatment may be limited by the adverse events of current availabl...
Chelsey C Damphousse,Jaclyn K Medeiros,Nicole E Micks et al.
Chelsey C Damphousse et al.
Type 2 diabetes mellitus has steadily increased in prevalence over the past five decades. Among the health risks associated with this disorder are cognitive decline and are increased risk of developing dementia. To further investigate the l...
Optogenetic stimulation of the primary visual cortex drives activity in the visual association cortex [0.03%]
初级视觉皮层的光遗传学刺激驱动视觉相关皮层的活动
Michael Ortiz-Rios,Beshoy Agayby,Fabien Balezeau et al.
Michael Ortiz-Rios et al.
Developing optogenetic methods for research in non-human primates (NHP) is important for translational neuroscience and for delineating brain function with unprecedented specificity. Here we assess, in macaque monkeys, the selectivity by wh...
Unilateral caudate inactivation increases motor impulsivity in rhesus monkeys [0.03%]
单侧尾状核失活可增加恒河猴的运动冲动性
Mark A G Eldridge,Maya C Smith,Scott Hunter Oppler et al.
Mark A G Eldridge et al.
Impulsivity, the tendency to react quickly and without consideration of consequences, is correlated with asymmetry in the volume of the caudate nucleus in human patients. In this study, we sought to determine whether the induction of functi...
Dynamic structural remodeling of the human visual system prompted by bilateral retinal gene therapy [0.03%]
双侧视网膜基因治疗引起的视觉系统动态结构重塑
Manzar Ashtari,Philip Cook,Mikhail Lipin et al.
Manzar Ashtari et al.
The impact of changes in visual input on neuronal circuitry is complex and much of our knowledge on human brain plasticity of the visual systems comes from animal studies. Reinstating vision in a group of patients with low vision through re...
A framework and resource for global collaboration in non-human primate neuroscience [0.03%]
非人灵长类神经科学全球合作的框架和资源
Renée Hartig,P Christiaan Klink,Zlata Polyakova et al.
Renée Hartig et al.
As science and technology evolve, there is an increasing need for promotion of international scientific exchange. Collaborations, while offering substantial opportunities for scientists and benefit to society, also present challenges for th...