Unilateral caudate inactivation increases motor impulsivity in rhesus monkeys [0.03%]
单侧尾状核失活可增加恒河猴的运动冲动性
Mark A G Eldridge,Maya C Smith,Scott Hunter Oppler et al.
Mark A G Eldridge et al.
Impulsivity, the tendency to react quickly and without consideration of consequences, is correlated with asymmetry in the volume of the caudate nucleus in human patients. In this study, we sought to determine whether the induction of functi...
Dynamic structural remodeling of the human visual system prompted by bilateral retinal gene therapy [0.03%]
双侧视网膜基因治疗引起的视觉系统动态结构重塑
Manzar Ashtari,Philip Cook,Mikhail Lipin et al.
Manzar Ashtari et al.
The impact of changes in visual input on neuronal circuitry is complex and much of our knowledge on human brain plasticity of the visual systems comes from animal studies. Reinstating vision in a group of patients with low vision through re...
A framework and resource for global collaboration in non-human primate neuroscience [0.03%]
非人灵长类神经科学全球合作的框架和资源
Renée Hartig,P Christiaan Klink,Zlata Polyakova et al.
Renée Hartig et al.
As science and technology evolve, there is an increasing need for promotion of international scientific exchange. Collaborations, while offering substantial opportunities for scientists and benefit to society, also present challenges for th...
Efficient viral expression of a chemogenetic receptor in the old-world monkey amygdala [0.03%]
高效地在旧大陆猴杏仁核中表达化学遗传受体病毒感染系统
Walter Lerchner,Kiana Dash,Deborah Rose et al.
Walter Lerchner et al.
Genetically encoded synthetic receptors, such as the chemogenetic and optogenetic proteins, are powerful tools for functional brain studies in animals. In the primate brain, with its comparatively large, intricate anatomical structures, it ...
Motion distractors perturb saccade programming later in time than static distractors [0.03%]
运动性分散刺激比静止性分散刺激更晚干扰扫视计划
Devin H Kehoe,Lukas Schießer,Hassaan Malik et al.
Devin H Kehoe et al.
The mechanism that reweights oculomotor vectors based on visual features is unclear. However, the latency of oculomotor visual activations gives insight into their antecedent featural processing. We compared the oculomotor processing time c...
Are musical activities associated with enhanced speech perception in noise in adults? A systematic review and meta-analysis [0.03%]
音乐活动与成人噪声环境中言语感知改善之间的关系：系统评价和meta分析
Elisabeth Maillard,Marilyne Joyal,Micah M Murray et al.
Elisabeth Maillard et al.
The ability to process speech in noise (SPiN) declines with age, with a detrimental impact on life quality. Music-making activities such as singing and playing a musical instrument have raised interest as potential prevention strategies for...
Gonzalo Forno,Manojkumar Saranathan,Jose Contador et al.
Gonzalo Forno et al.
Alzheimer's disease (AD) is the most common cause of dementia worldwide. Increasing evidence points to the thalamus as an important hub in the clinical symptomatology of the disease, with the 'limbic thalamus' been described as especially v...
Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system [0.03%]
腺相关病毒技术递送基因编码货物至非人灵长类神经系统载货的研究进展
Lillian J Campos,Cynthia M Arokiaraj,Miguel R Chuapoco et al.
Lillian J Campos et al.
Modern neuroscience approaches including optogenetics, calcium imaging, and other genetic manipulations have facilitated our ability to dissect specific circuits in rodent models to study their role in neurological disease. These approaches...
Stimulus contrast modulates burst activity in the lateral geniculate nucleus [0.03%]
刺激对比度调制外侧膝状体的爆发活动
Alyssa N Sanchez,Henry J Alitto,Daniel L Rathbun et al.
Alyssa N Sanchez et al.
Burst activity is a ubiquitous feature of thalamic neurons and is well documented for visual neurons in the lateral geniculate nucleus (LGN). Although bursts are often associated with states of drowsiness, they are also known to convey visu...
Alterations of fractional anisotropy throughout cortico-basal ganglia gray matter in a macaque model of Huntington's Disease [0.03%]
亨廷顿舞蹈病猕猴模型中皮层-纹状体灰质各向异性的改变
Alison R Weiss,William A Liguore,Kristin Brandon et al.
Alison R Weiss et al.
We recently generated a nonhuman primate (NHP) model of the neurodegenerative disorder Huntington's disease (HD) using adeno-associated viral vectors to express a fragment of mutant HTT protein (mHTT) throughout the cortico-basal ganglia ci...