Subcortical coding of predictable and unsupervised sound-context associations [0.03%]
皮层下可预测及非监督声音-环境关联编码
Chi Chen,Hugo Cruces-Solís,Alexandra Ertman et al.
Chi Chen et al.
Our environment is made of a myriad of stimuli present in combinations often patterned in predictable ways. For example, there is a strong association between where we are and the sounds we hear. Like many environmental patterns, sound-cont...
Neuromodulation of the anterior thalamus: Current approaches and opportunities for the future [0.03%]
前丘脑神经调控：当前方法及未来机遇
Pooja Venkatesh,Cody Wolfe,Bradley Lega;Illustrations by Corbyn BeachCorbyn.Beach@UTSouthwestern.edu
Pooja Venkatesh
The role of thalamocortical circuits in memory has driven a recent burst of scholarship, especially in animal models. Investigating this circuitry in humans is more challenging. And yet, the development of new recording and stimulation tech...
From X-inactivation to neurodevelopment: CHD8-transcription factors (TFs) competitive binding at regulatory regions of CHD8 target genes can contribute to correct neuronal differentiation [0.03%]
从X染色体失活到神经发育：CHD8-转录因子在CHD8靶基因调控区域的竞争性结合有助于正确的神经元分化
Andrea Cerase,Philip Avner
Andrea Cerase
The chromodomain helicase DNA-binding protein 8 (CHD8) is a chromatin remodeler whose mutation is associated, with high penetrance, with autism. Individuals with CHD8 mutations share common symptoms such as autistic behaviour, cognitive imp...
Implicit auditory memory in older listeners: From encoding to 6-month retention [0.03%]
老年人的听觉记忆：从编码到六月后保持力
Roberta Bianco,Edward T R Hall,Marcus T Pearce et al.
Roberta Bianco et al.
Any listening task, from sound recognition to sound-based communication, rests on auditory memory which is known to decline in healthy ageing. However, how this decline maps onto multiple components and stages of auditory memory remains poo...
DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates [0.03%]
DREADD介导的杏仁核激活足以在年轻非人灵长类动物中诱导类似焦虑的反应
Sascha A L Mueller,Jonathan A Oler,Patrick H Roseboom et al.
Sascha A L Mueller et al.
Anxiety disorders are among the most prevalent psychiatric disorders, with symptoms often beginning early in life. To model the pathophysiology of human pathological anxiety, we utilized Designer Receptors Exclusively Activated by Designer ...
Apnea of prematurity induces short and long-term development-related transcriptional changes in the murine cerebellum [0.03%]
早产儿呼吸暂停会诱导小鼠小脑中与发育相关的短期和长期转录变化
A Rodriguez-Duboc,M Basille-Dugay,A Debonne et al.
A Rodriguez-Duboc et al.
Apnea of prematurity (AOP) affects more than 50% of preterm infants and leads to perinatal intermittent hypoxia (IH) which is a major cause of morbimortality worldwide. At birth, the human cerebellar cortex is still immature, making it vuln...
Δ9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults [0.03%]
与成人不同，大麻主要成分THC不会在青少年大脑中上调厌恶性多巴胺受体机制
Marie-Eve Di Raddo,Marija Milenkovic,Meenalochani Sivasubramanian et al.
Marie-Eve Di Raddo et al.
Earlier age of cannabis usage poses higher risk of Cannabis Use Disorder and adverse consequences, such as addiction, anxiety, dysphoria, psychosis, largely attributed to its principal psychoactive component, Δ9-tetrahydrocannabinol (THC) ...
GABAB receptor outward currents are transiently disclosed by the convulsant 4-aminopyridine in vitro [0.03%]
拮抗剂4-氨基吡啶短暂诱导GABA_B受体外向电流的离体研究
Adriano Cattani,Siyan Wang,Maxime Lévesque et al.
Adriano Cattani et al.
The K+ channel blocker 4-aminopyridine (4AP) has been extensively used to investigate the mechanisms underlying neuronal network synchronization in both in vitro and in vivo animal models of focal epilepsy. 4AP-induced effects are parallele...
Shahriar SheikhBahaei,Marissa Millwater,Gerald A Maguire
Shahriar SheikhBahaei
Childhood-onset fluency disorder, commonly referred to as stuttering, affects over 70 million adults worldwide. While stuttering predominantly initiates during childhood and is more prevalent in males, it presents consistent symptoms during...
Serotonergic mediation of the brain-wide neurogenesis: Region-dependent and receptor-type specific roles on neurogenic cellular transformation [0.03%]
五羟色胺介导的脑内神经发生：区域依赖性和受体类型特异性神经发生细胞转化作用
Yuki Higuchi,Hiroyuki Arakawa
Yuki Higuchi
Brain serotonin (5-hydroxytryptamine, 5-HT) is a key molecule for the mediation of depression-related brain states, but the neural mechanisms underlying 5-HT mediation need further investigation. A possible mechanism of the therapeutic anti...