Nine Kompier,Marcus Semtner,Sophie Walter et al.
Nine Kompier et al.
We established a longitudinal acute slice preparation of transgenic mouse optic nerve to characterize membrane properties and coupling of glial cells by patch-clamp and dye-filling, complemented by immunohistochemistry. Unlike in cortex or ...
Ablation of Iron Regulatory Protein 2 produces a neurological disorder characterized by motor, somatosensory, and executive dysfunction in mice [0.03%]
铁调节蛋白2缺失产生一种以运动、躯体感觉和执行功能障碍为主的神经性疾病的小鼠模型
Christina Porras,Hayden Olliviere,Sean P Bradley et al.
Christina Porras et al.
Iron is an important cofactor for many proteins and is used to create Fe-S clusters and heme prosthetic groups that enzymes use to catalyze enzymatic reactions. Proteins involved in the import, export, and sequestration of iron are regulate...
Ictal activity is sustained by the estrogen receptor β during the estrous cycle [0.03%]
雌激素受体β在动情周期中维持痫样活动
Fei Ran Li,Maxime Lévesque,Siyan Wang et al.
Fei Ran Li et al.
Catamenial epilepsy, defined as a periodicity of seizure exacerbation during the menstrual cycle, affects up to 70 % of epileptic women. Seizures in these patients are often non-responsive to medication; however, our understanding of the re...
Tonotopic organization of auditory cortex in awake marmosets revealed by multi-modal wide-field optical imaging [0.03%]
宽视场光学成像揭示觉醒狨猴听皮层的音调拓扑分区
Xindong Song,Yueqi Guo,Chenggang Chen et al.
Xindong Song et al.
Tonotopic organization of the auditory cortex has been extensively studied in many mammalian species using various methodologies and physiological preparations. Tonotopy mapping in primates, however, is more limited due to constraints such ...
The type of inhibition provided by thalamic interneurons alters the input selectivity of thalamocortical neurons [0.03%]
丘脑中间神经元提供的抑制类型改变了丘脑皮层神经元的输入选择性
Deyl Djama,Florian Zirpel,Zhiwen Ye et al.
Deyl Djama et al.
A fundamental problem in neuroscience is how neurons select for their many inputs. A common assumption is that a neuron's selectivity is largely explained by differences in excitatory synaptic input weightings. Here we describe another solu...
Cellular mechanisms of cooperative context-sensitive predictive inference [0.03%]
协同的上下文相关的预测推理的细胞机制
Tomáš Marvan,William A Phillips
Tomáš Marvan
We argue that prediction success maximization is a basic objective of cognition and cortex, that it is compatible with but distinct from prediction error minimization, that neither objective requires subtractive coding, that there is clear ...
Decrease in phase slip rates and phase cone structures during seizure evolution and epileptogenic activities derived from microgrid ECoG data [0.03%]
基于微网格ECoG数据的癫痫发作过程中相位滑移速率降低和相位锥结构变化的研究
Ceon Ramon,Alexander Doud,Mark D Holmes
Ceon Ramon
Sudden phase changes are related to cortical phase transitions, which likely change in frequency and spatial distribution as epileptogenic activity evolves. A 100 s long section of micro-ECoG data obtained before and during a seizure was se...
Protective effects of Embelin in Benzo[α]pyrene induced cognitive and memory impairment in experimental model of mice [0.03%]
Embelin对苯并[a]芘致小鼠认知记忆损伤的保护作用研究
Akansh Goal,Khadga Raj,Shamsher Singh et al.
Akansh Goal et al.
Alzheimer's disease (AD) is a neurodegenerative disease that affects the neurons in the hippocampus, resulting in cognitive and memory impairment. The most prominent clinical characteristics of AD are the production of amyloid-beta (Aβ) pl...
Hearing loss in juvenile rats leads to excessive play fighting and hyperactivity, mild cognitive deficits and altered neuronal activity in the prefrontal cortex [0.03%]
幼年期听力损失可导致大鼠过度嬉戏和多动、轻度认知缺陷及前额叶神经元活动异常
Jonas Jelinek,Marie Johne,Mesbah Alam et al.
Jonas Jelinek et al.
Background: In children, hearing loss has been associated with hyperactivity, disturbed social interaction, and risk of cognitive disturbances. Mechanistic explanations of these relations sometimes involve language. To in...
Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex [0.03%]
表达副球蛋白的GABA能中间神经元在皮层高频振荡中的生理特征
Katarina D Milicevic,Brianna L Barbeau,Darko D Lovic et al.
Katarina D Milicevic et al.
Parvalbumin-expressing (PV+) inhibitory interneurons drive gamma oscillations (30-80 Hz), which underlie higher cognitive functions. In this review, we discuss two groups/aspects of fundamental properties of PV+ interneurons. In the first g...