M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance [0.03%]
M₁受体与NMDA受体相互作用可增强延迟相关的神经元放电并改善工作记忆表现
Veronica C Galvin,Shengtao Yang,Adam S Lowet et al.
Veronica C Galvin et al.
The recurrent excitatory circuits in dlPFC underlying working memory are known to require activation of glutamatergic NMDA receptors (NMDAR). The neurons in these circuits also rely on acetylcholine to maintain persistent activity, with evi...
Cholinergic modulation of hierarchical inhibitory control over cortical resting state dynamics: Local circuit modeling of schizophrenia-related hypofrontality [0.03%]
胆碱能对皮层静息状态动力学的等级抑制控制的乙酰胆碱调节-局部神经元环路建模在与精神分裂症相关的低额叶水平中的应用
Marie Rooy,Ivan Lazarevich,Fani Koukouli et al.
Marie Rooy et al.
Nicotinic acetylcholine receptors (nAChRs) modulate the cholinergic drive to a hierarchy of inhibitory neurons in the superficial layers of the PFC, critical to cognitive processes. It has been shown that genetic deletions of the various ty...
The transcriptional repressor Rev-erbα regulates circadian expression of the astrocyte Fabp7 mRNA [0.03%]
反式抑制物Rev-erbα调节星形胶质细胞Fabp7 mRNA的昼夜表达
William M Vanderheyden,Bin Fang,Carlos C Flores et al.
William M Vanderheyden et al.
The astrocyte brain-type fatty-acid binding protein (Fabp7) circadian gene expression is synchronized in the same temporal phase throughout mammalian brain. Cellular and molecular mechanisms that contribute to this coordinated expression ar...
Ion-channel regulation of response decorrelation in a heterogeneous multi-scale model of the dentate gyrus [0.03%]
异质多尺度海马齿状回模型中的离子通道调控反应去相关性
Poonam Mishra,Rishikesh Narayanan
Poonam Mishra
Heterogeneities in biological neural circuits manifest in afferent connectivity as well as in local-circuit components such as neuronal excitability, neural structure and local synaptic strengths. The expression of adult neurogenesis in the...