Regulation of neuronal excitability by reactive oxygen species and calcium signaling: Insights into brain aging [0.03%]
活性氧和钙信号调控神经元兴奋性及其在脑衰老中的作用机制初探
Rachel L Doser,Frederic J Hoerndli
Rachel L Doser
Altered cognition and inefficient learning and memory are hallmarks of brain aging resulting from many small changes in the structure and function of neurons. One such change is a decrease in excitatory synaptic transmission mediated by glu...
Tactile information from the vibrissal system modulates hippocampal functioning [0.03%]
触须系统的感觉信息调节海马功能
Nereida Ibarra-Castañeda,Norma A Moy-Lopez,Óscar González-Pérez
Nereida Ibarra-Castañeda
Most mammals have sensory tactile hairs, also known as whiskers or vibrissae. Traditionally, whiskers are associated with diverse survival skills, including tactile discrimination, distance assessment, food acquisition, gap crossing, and so...
The molecular neurobiology and neuropathology of opioid use disorder [0.03%]
阿片类物质使用障碍的分子神经生物学和神经病理学
Christopher A Blackwood,Jean Lud Cadet
Christopher A Blackwood
The number of people diagnosed with opioid use disorder has skyrocketed as a consequence of the opioid epidemic and the increased prescribing of opioid drugs for chronic pain relief. Opioid use disorder is characterized by loss of control o...
Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles [0.03%]
早期睡眠紊乱会破坏草原田鼠前额叶皮层的谷氨酸和树突棘并损害其认知灵活性
Carolyn E Jones,Alex Q Chau,Randall J Olson et al.
Carolyn E Jones et al.
Early life experiences are crucial for proper organization of excitatory synapses within the brain, with outsized effects on late-maturing, experience-dependent regions such as the medial prefrontal cortex (mPFC). Previous work in our lab s...
M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance [0.03%]
M₁受体与NMDA受体相互作用可增强延迟相关的神经元放电并改善工作记忆表现
Veronica C Galvin,Shengtao Yang,Adam S Lowet et al.
Veronica C Galvin et al.
The recurrent excitatory circuits in dlPFC underlying working memory are known to require activation of glutamatergic NMDA receptors (NMDAR). The neurons in these circuits also rely on acetylcholine to maintain persistent activity, with evi...
Cholinergic modulation of hierarchical inhibitory control over cortical resting state dynamics: Local circuit modeling of schizophrenia-related hypofrontality [0.03%]
胆碱能对皮层静息状态动力学的等级抑制控制的乙酰胆碱调节-局部神经元环路建模在与精神分裂症相关的低额叶水平中的应用
Marie Rooy,Ivan Lazarevich,Fani Koukouli et al.
Marie Rooy et al.
Nicotinic acetylcholine receptors (nAChRs) modulate the cholinergic drive to a hierarchy of inhibitory neurons in the superficial layers of the PFC, critical to cognitive processes. It has been shown that genetic deletions of the various ty...
The transcriptional repressor Rev-erbα regulates circadian expression of the astrocyte Fabp7 mRNA [0.03%]
反式抑制物Rev-erbα调节星形胶质细胞Fabp7 mRNA的昼夜表达
William M Vanderheyden,Bin Fang,Carlos C Flores et al.
William M Vanderheyden et al.
The astrocyte brain-type fatty-acid binding protein (Fabp7) circadian gene expression is synchronized in the same temporal phase throughout mammalian brain. Cellular and molecular mechanisms that contribute to this coordinated expression ar...
Ion-channel regulation of response decorrelation in a heterogeneous multi-scale model of the dentate gyrus [0.03%]
异质多尺度海马齿状回模型中的离子通道调控反应去相关性
Poonam Mishra,Rishikesh Narayanan
Poonam Mishra
Heterogeneities in biological neural circuits manifest in afferent connectivity as well as in local-circuit components such as neuronal excitability, neural structure and local synaptic strengths. The expression of adult neurogenesis in the...