Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation [0.03%]
在APP敲入型阿尔茨海默病小鼠模型中GABA作用的正变构调节性别依赖性敏感性的潜在表观遗传调控
James Auta,Andrea Locci,Alessandro Guidotti et al.
James Auta et al.
Conflicting evidence suggest that perturbations of GABAergic neurotransmission play crucial roles in disrupting cortical neuronal network oscillations, memory, and cognitive deficits in Alzheimer's disease (AD). However, the role and impact...
Distracting linguistic information impairs neural tracking of attended speech [0.03%]
分散注意力的语义信息会损害神经对正在注意的声音的跟踪能力
Bohan Dai,James M McQueen,René Terporten et al.
Bohan Dai et al.
Listening to speech is difficult in noisy environments, and is even harder when the interfering noise consists of intelligible speech as compared to unintelligible sounds. This suggests that the competing linguistic information interferes w...
Understanding them to understand ourselves: The importance of NHP research for translational neuroscience [0.03%]
理解它们以更好地理解我们自己：灵长类动物研究对转化神经科学研究的重要性
Annabella Lear,Stuart N Baker,Hannah F Clarke et al.
Annabella Lear et al.
Studying higher brain function presents fundamental scientific challenges but has great potential for impactful translation to the clinic, supporting the needs of many patients suffering from conditions that relate to neuronal dysfunction. ...
A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model [0.03%]
运动中的思维：锻炼可以改善认知灵活性，冲动，并改变帕金森病大鼠模型的多巴胺受体基因表达
Wang Zhuo,Adam J Lundquist,Erin K Donahue et al.
Wang Zhuo et al.
Cognitive impairment, particularly deficits in executive function (EF) is common in Parkinson's disease (PD) and may lead to dementia. There are currently no effective treatments for cognitive impairment. Work from our lab and others has sh...
Microstructural interactions contribute to the hotspot in the living cochlea [0.03%]
微观结构相互作用导致了耳蜗中的热点现象
Junpei Liu,Yanru Bai,Qianli Cheng et al.
Junpei Liu et al.
The mechanism of the active cochlea relies on a complex interaction between microstructures in the organ of Corti. A significant longitudinal vibration "hotspot" was recently observed in the high-frequency region of the living gerbil cochle...
Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex [0.03%]
大鼠内侧前额皮层中由小胶质细胞引发的锥体神经元低兴奋性可塑性
Yuki Yamawaki,Yayoi Wada,Sae Matsui et al.
Yuki Yamawaki et al.
Lipopolysaccharide (LPS), an outer component of Gram-negative bacteria, induces a strong response of innate immunity via microglia, which triggers a modulation of the intrinsic excitability of neurons. However, it is unclear whether the mod...
Plasticity of cell proliferation in the retina of Austrolebias charrua fish under light and darkness conditions [0.03%]
光和暗条件下Austrolebias charrua鱼视网膜细胞增殖的可塑性研究
Inés Berrosteguieta,Juan Carlos Rosillo,María Laura Herrera et al.
Inés Berrosteguieta et al.
Austrolebias annual fishes exhibit cell proliferation and neurogenesis throughout life. They withstand extreme environmental changes as their habitat dries out, pressuring nervous system to adapt. Their visual system is challenged to adjust...
Visual modulation of firing and spectrotemporal receptive fields in mouse auditory cortex [0.03%]
小鼠听皮层的神经元放电和频谱时间感受野的视觉调制效应研究
James Bigelow,Ryan J Morrill,Timothy Olsen et al.
James Bigelow et al.
Recent studies have established significant anatomical and functional connections between visual areas and primary auditory cortex (A1), which may be important for cognitive processes such as communication and spatial perception. These stud...
Gender differences in brain activity when exposed to cyberbullying: Associations between wellbeing and cyberbullying experience using functional Magnetic Resonance Imaging [0.03%]
接触网络欺凌时的性别大脑活动差异：使用功能磁共振成像评估网络欺凌经历与幸福感之间的联系
Larisa T McLoughlin,Zack Shan,Abdalla Mohamed et al.
Larisa T McLoughlin et al.
The role of gender and the associated brain activation when witnessing cyberbullying requires investigation. The current study aimed to determine whether brain responses to cyberbullying differ according to gender and level of wellbeing. We...
Glial fibrillary acidic protein level on admission can predict severe traumatic brain injury in patients with severe multiple trauma: A single-center retrospective observational study [0.03%]
入院时胶质纤维酸性蛋白水平可预测严重多发伤患者发生严重颅脑创伤的可能：单中心回顾观察研究
Yoshihiko Nakamura,Taisuke Kitamura,Yasumasa Kawano et al.
Yoshihiko Nakamura et al.
Objective: This study aimed to clarify whether the glial fibrillary acidic protein (GFAP) and soluble protein-100β (S100β) can predict severe traumatic brain injury (TBI) in patients with severe multiple trauma. ...