Methods for shipping live primary cortical and hippocampal neuron cultures from postnatal mice [0.03%]
用于运输来自新生小鼠的初级皮层和海马神经元培养物的方法
Ferass M Sammoura,Dina Popova,Ayeshia Morris et al.
Ferass M Sammoura et al.
Primary neuronal cultures have proven to be a powerful tool for studying mechanisms in neuroscience. It is technically challenging and expensive to reproduce high quality viable neuronal cultures. Laboratories that are not experienced or eq...
Insulin-like growth factor-1 stimulates retinal cell proliferation via activation of multiple signaling pathways [0.03%]
胰岛素样生长因子-1通过激活多个信号通路刺激视网膜细胞增殖
Camila Saggioro de Figueiredo,Ícaro Raony,Simone Vidal Medina et al.
Camila Saggioro de Figueiredo et al.
Insulin-like growth factor-1 (IGF-1) plays critical roles in the development of the central nervous system (CNS), including the retina, regulating cell proliferation, differentiation, and survival. Here, we investigated the role of IGF-1 on...
Peter Janssen,Tadashi Isa,Jose Lanciego et al.
Peter Janssen et al.
Future neuroscience and biomedical projects involving non-human primates (NHPs) remain essential in our endeavors to understand the complexities and functioning of the mammalian central nervous system. In so doing, the NHP neuroscience rese...
Behavioral detectability of optogenetic stimulation of inferior temporal cortex varies with the size of concurrently viewed objects [0.03%]
不同大小的同时视物体对下颞叶皮层的光遗传刺激的行为探测性有不同的影响
Rosa Lafer-Sousa,Karen Wang,Reza Azadi et al.
Rosa Lafer-Sousa et al.
We have previously demonstrated that macaque monkeys can behaviorally detect a subtle optogenetic impulse delivered to their inferior temporal (IT) cortex. We have also shown that the ability to detect the cortical stimulation impulse varie...
Nonlinear EEG signatures of mind wandering during breath focus meditation [0.03%]
专注呼吸冥想时心神不定的非线性脑电波信号特征
Yiqing Lu,Julio Rodriguez-Larios
Yiqing Lu
In meditation practices that involve focused attention to a specific object, novice practitioners often experience moments of distraction (i.e., mind wandering). Previous studies have investigated the neural correlates of mind wandering dur...
Investigating effortful speech perception using fNIRS and pupillometry measures [0.03%]
利用fNIRS和瞳孔测量研究努力的语音知觉
Xin Zhou,Emily Burg,Alan Kan et al.
Xin Zhou et al.
The current study examined the neural mechanisms for mental effort and its correlation to speech perception using functional near-infrared spectroscopy (fNIRS) in listeners with normal hearing (NH). Data were collected while participants li...
Embelin prevents amyloid-beta accumulation via modulation of SOD1 in a Streptozotocin-induced AD-like condition: An evidence from in vitro investigation [0.03%]
Embelin通过调节SOD1预防淀粉样蛋白-β在链脲佐菌素诱导的类似AD状态下的积累：体外研究的证据
Saatheeyavaane Bhuvanendran,Yam Nath Paudel,Yatinesh Kumari et al.
Saatheeyavaane Bhuvanendran et al.
Embelin is a neuroprotective compound with therapeutic benefit against experimental Alzheimer's disease (AD)-like condition. In the quest of untangling the underlying mechanism behind the neuroprotective effect of Embelin in AD, an in-vitro...
Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation [0.03%]
在APP敲入型阿尔茨海默病小鼠模型中GABA作用的正变构调节性别依赖性敏感性的潜在表观遗传调控
James Auta,Andrea Locci,Alessandro Guidotti et al.
James Auta et al.
Conflicting evidence suggest that perturbations of GABAergic neurotransmission play crucial roles in disrupting cortical neuronal network oscillations, memory, and cognitive deficits in Alzheimer's disease (AD). However, the role and impact...
Distracting linguistic information impairs neural tracking of attended speech [0.03%]
分散注意力的语义信息会损害神经对正在注意的声音的跟踪能力
Bohan Dai,James M McQueen,René Terporten et al.
Bohan Dai et al.
Listening to speech is difficult in noisy environments, and is even harder when the interfering noise consists of intelligible speech as compared to unintelligible sounds. This suggests that the competing linguistic information interferes w...
Understanding them to understand ourselves: The importance of NHP research for translational neuroscience [0.03%]
理解它们以更好地理解我们自己：灵长类动物研究对转化神经科学研究的重要性
Annabella Lear,Stuart N Baker,Hannah F Clarke et al.
Annabella Lear et al.
Studying higher brain function presents fundamental scientific challenges but has great potential for impactful translation to the clinic, supporting the needs of many patients suffering from conditions that relate to neuronal dysfunction. ...