From acute tubular injury to tubular repair and chronic kidney diseases - KIM-1 as a promising biomarker for predicting renal tubular pathology [0.03%]
从急性肾小管损伤到肾小管修复及慢性肾脏病——KIM-1作为预测肾小管病理损伤的标志物的前景
Ping L Zhang,Ming-Lin Liu
Ping L Zhang
Kidney Injury Molecule-1 (KIM-1) has emerged as a significant biomarker and mechanistic player in kidney pathology, particularly in acute kidney injury (AKI). Normally absent in healthy kidney proximal tubules, KIM-1 becomes upregulated spe...
You don't know what you don't know; using high school outreach to improve awareness of bioscience-based careers and higher education [0.03%]
无知之知——利用中学开放日增进对生物科技职业及高等教育的认识与了解
Christine Greensmith,David Greensmith
Christine Greensmith
When considering the diversity of students in higher education, an important but frequently overlooked characteristic is socioeconomic background. It is well known that those from socially disadvantaged backgrounds are less likely to progre...
High carbohydrate diet programs metabolic enzyme gene expression modification in F2 generation wistar rat males [0.03%]
高碳水化合物饮食可诱导后代大鼠的代谢酶基因表达改变
Joseph Chimezie,Worship Odosa Agbonifo,Hope Oluwabukola Francis et al.
Joseph Chimezie et al.
Diets high in carbohydrates (HCD) negatively impact transgenerational metabolic health and phenotype, factors directly influenced by gene expression. This study investigates the effects of HCD feeding on gene expression of key enzymes of im...
Moderate chronic aortic constriction induces modest, sex-specific effects on rat hearts and skeletal muscle [0.03%]
中度慢性主动脉缩窄对大鼠心脏和骨骼肌的性激素特异性影响较小
William S Evans,Yuan Liu,Maria Clara Canellas Da Silva et al.
William S Evans et al.
Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50 % of heart failure diagnoses, occurs in older individuals, is more prevalent in females than males, and includes hypertension as contributing factor. We sought to dete...
Enhancing career development for biomedical sciences Students: Leveraging simulations to support patient-facing careers [0.03%]
增强生物医学科学专业学生的生涯发展：利用模拟手段支持面向患者的职业生涯
Komal Amar,Matthew Jones,Nathan Connell et al.
Komal Amar et al.
Simulations have become integral to medical education for professions such as nursing and medicine but are still a rare opportunity for students undertaking basic science courses including Biomedical Sciences. Many students undertaking Biom...
Protective effect of the Quercetin on experimental cuprizone-induced multiple sclerosis in male C57BL/6 mice [0.03%]
槲皮素对小鼠实验性脱髓鞘病变的保护作用研究
Samin Ghasemi,Shahin Hassanpour,Razieh Hosseini
Samin Ghasemi
This study aimed to determine protective effect of the Quercetin on experimental cuprizone-induced (CPZ) multiple sclerosis (MS) in Male C57BL/6 mice. Forty male C57BL/6 mice were allocated into 4 experimental groups. Control group received...
1H MRS-based metabolite changes at ventral respiratory control centers of the medulla oblongata following administration of morphine in wild-type and GIRK2 mutant mice [0.03%]
吗啡作用于野生型和GIRK2突变小鼠延髓呼吸控制中心的代谢变化：一种基于1H MRS技术的方法
Ozra Dehkordi,Stephen Lin,Safia Mohamud et al.
Ozra Dehkordi et al.
Respiratory depression is the leading cause of death in opioid overdose and is closely associated with the development of tolerance following repeated morphine use. However, the neurochemical adaptations in brainstem regions that regulate b...
Sex-related differences in the acute physiological response to a high-intensity CrossFit® workout [0.03%]
高强度Crossfit训练的急性生理反应的性别差异研究
Manoel Rios,Ricardo Cardoso,Victor Machado Reis et al.
Manoel Rios et al.
CrossFit® is popular form of fitness training but the cardiorespiratory, hemodynamic and metabolic responses have not been well characterised. We compared responses to a short Fran CrossFit® session (consisting of three rounds of 21, 15 a...
No sex differences in fatigability or neuromuscular responses during one set of maximal intended velocity muscle actions to failure at 30 % one-repetition maximum [0.03%]
在30%一次重复最大负荷下，单组最大预期速度肌肉动作至衰竭时男女疲劳性及神经肌肉反应无差异
Tyler J Neltner,Robert W Smith,Jocelyn E Arnett et al.
Tyler J Neltner et al.
Traditionally, research using dynamic constant external resistance (DCER) training has focused on self-selected velocities. This study aimed to examine sex differences in fatigability and neuromuscular responses during maximal intended velo...
Acidosis enhances contribution of Ca2+-activated chloride channels to vascular tone regulation in early postnatal period [0.03%]
酸中毒增强Ca2+激活的Cl-通道在产后早期血管张力调节中的作用
Anastasia A Shvetsova,Margarita A Khlystova,Valentina S Shateeva et al.
Anastasia A Shvetsova et al.
Introduction: Acidosis often occurs during clinical complications in newborns and can lead to changes in the mechanisms of arterial tone regulation. However, it is unknown how acidosis affects the activity of Ca2+-activat...